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5CHZ
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BU of 5chz by Molmil
Structure of wild-type human MBD4 bound to a G:T mismatch
Descriptor: 12-mer DNA(G), 5-mer DNA, 7-mer DNA, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2015-07-10
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure of wild-type human MBD4 bound to a G:T mismatch
To Be Published
6MXO
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BU of 6mxo by Molmil
Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG
Descriptor: (cyclohex-1-ene-1,2-diamine)platinum(2+), 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
Authors:Ouzon-Shubeita, H, Lee, S.
Deposit date:2018-10-31
Release date:2019-02-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase eta.
Biochem. J., 476, 2019
6U2O
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BU of 6u2o by Molmil
Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ...
Authors:Ouzon-Shubeita, H, Vilas, C.K, Lee, S.
Deposit date:2019-08-20
Release date:2020-08-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Mutagenic Bypass of the Major Cisplatin-DNA Lesion by Human DNA Polymerase Beta Reveal Insights into Cisplatin-Induced Mutagenesis
To Be Published
6U6B
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BU of 6u6b by Molmil
Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ...
Authors:Ouzon-Shubeita, H, Vilas, C.K, Lee, S.
Deposit date:2019-08-29
Release date:2020-09-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.108 Å)
Cite:Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion.
Biochem.J., 477, 2020
4OFH
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BU of 4ofh by Molmil
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
Descriptor: 12-mer DNA(O6MeG), 12-mer DNA(T), MAGNESIUM ION, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2014-01-14
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure of MBD4 bound to O6MeG:T mispair DNA
To be Published
4OFE
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BU of 4ofe by Molmil
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
Descriptor: 12-mer DNA(G), 12-mer DNA(T), MAGNESIUM ION, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2014-01-14
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of R468K/D560N MBD4 bound to G:T mispair DNA
To be Published
4OFA
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BU of 4ofa by Molmil
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
Descriptor: 12-mer DNA(G), 12-mer DNA(T), MAGNESIUM ION, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2014-01-14
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of MBD4 bound to G:T mispair DNA
To be Published
6VJW
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BU of 6vjw by Molmil
Crystal structure of WT hMBD4 complexed with T:G mismatch DNA
Descriptor: DNA (5'-D(*CP*CP*AP*GP*CP*GP*(ORP)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), Methyl-CpG-binding domain protein 4
Authors:Jung, H, Lee, S.
Deposit date:2020-01-17
Release date:2021-01-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4.
Biochem.J., 477, 2020
4F4B
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BU of 4f4b by Molmil
Structure of OSH4 with a cholesterol analog
Descriptor: (3beta,9beta,25R)-3-hydroxy-26-iodocholest-5-ene-16,22-dione, Protein KES1
Authors:Koag, M.C, Monzingo, A.F, Cheun, Y, Lee, S.
Deposit date:2012-05-10
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Steroids, 78, 2013
4FES
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BU of 4fes by Molmil
Structure of OSH4 in complex with cholesterol analogs
Descriptor: (3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2S,6S)-6-methyl-3-oxooctan-2-yl]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-16H-cyclopenta[a]phenanthren-16-one, Protein KES1
Authors:Koag, M.C, Monzingo, A.F, Cheun, Y, Lee, S.
Deposit date:2012-05-30
Release date:2013-06-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Steroids, 78, 2013
5HHI
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BU of 5hhi by Molmil
Structure of human DNA polymerase beta Host-Guest complexed with CBZ-platinated N7-G
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*AP*GP*GP*AP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*TP*CP*CP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Lee, S, Koag, M.-C.
Deposit date:2016-01-11
Release date:2017-01-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.517 Å)
Cite:Synthesis, structure, and biological evaluation of a platinum-carbazole conjugate.
Chem Biol Drug Des, 91, 2018
5HHH
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BU of 5hhh by Molmil
Structure of human DNA polymerase beta Host-Guest complexed with the control G for N7-CBZ-platination
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*AP*GP*GP*AP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*TP*CP*CP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.-C, Lee, S.
Deposit date:2016-01-11
Release date:2017-01-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.363 Å)
Cite:Synthesis, structure, and biological evaluation of a platinum-carbazole conjugate.
Chem Biol Drug Des, 91, 2018
4O5E
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BU of 4o5e by Molmil
Structure of human DNA polymerase complexed with N7MG in the template base paired with incoming non-hydrolyzable TTP
Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.532 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014
4O5K
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BU of 4o5k by Molmil
Structure of human DNA polymerase complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.058 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014
4P2H
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BU of 4p2h by Molmil
Structure of human DNA polymerase complexed with N7MG in the template opposite to incoming non-hydrolyzable TTP with manganese in the active site
Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Lee, S, Koag, M.C.
Deposit date:2014-03-04
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.987 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014
4O5C
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BU of 4o5c by Molmil
Structure of human DNA polymerase complexed with N7-MG as the template base in a 1-nucleotide gapped DNA
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.363 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014

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PDB entries from 2024-09-18

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