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cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, MPE8 Single chain variable fragment, Structurally designed HMPV F protein HMPV_v3B_D12_DS454,Fibritin
Authors:	Zhou, T, Kwong, P.D, Morano, N.C, Ou, L.
Deposit date:	2022-11-17
Release date:	2023-08-02
Method:	ELECTRON MICROSCOPY (3.25 Å)
Cite:	cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8 To Be Published

2Z2D

Solution structure of human macrophage elastase (MMP-12) catalytic domain complexed with a gamma-keto butanoic acid inhibitor
Descriptor:	(3R)-3-{4-[(4-CHLOROPHENYL)ETHYNYL]BENZOYL}NONANOIC ACID, CALCIUM ION, Macrophage metalloelastase, ...
Authors:	Zheng, X, Ou, L.
Deposit date:	2007-05-18
Release date:	2007-11-20
Last modified:	2022-03-16
Method:	SOLUTION NMR
Cite:	Solution structure of human macrophage elastase (MMP-12) catalytic domain complexed with a gamma-keto butanoic acid inhibitor To be published

2DDY

Solution Structure of Matrilysin (MMP-7) Complexed to Constraint Conformational Sulfonamide Inhibitor
Descriptor:	(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE, CALCIUM ION, Matrilysin, ...
Authors:	Zheng, X.H, Ou, L.
Deposit date:	2006-02-06
Release date:	2007-02-06
Last modified:	2022-03-09
Method:	SOLUTION NMR
Cite:	Solution Structure of Matrilysin (MMP-7) Complexed to Constraint Conformational Sulfonamide Inhibitor to be published

6CDO

Structure of vaccine-elicited HIV-1 neutralizing antibody vFP16.02 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide 512-519, SULFATE ION, vFP16.02 Fab heavy chain, ...
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2018-02-08
Release date:	2018-05-16
Last modified:	2018-06-20
Method:	X-RAY DIFFRACTION (2.099 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

6CDP

Vaccine-elicited HIV-1 neutralizing antibody vFP20.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide 512-519, SULFATE ION, vFP20.01 Fab heavy chain, ...
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2018-02-08
Release date:	2018-05-16
Last modified:	2018-06-20
Method:	X-RAY DIFFRACTION (2.456 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

4HNJ

Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution
Descriptor:	Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:	Fisher, J.C, Yun, M.K, White, S.W.
Deposit date:	2012-10-19
Release date:	2013-01-23
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

2M03

Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains
Descriptor:	Bcl-2-like protein 1
Authors:	Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:	2012-10-19
Release date:	2013-01-30
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

2M04

Solution structure of BCL-xL in complex with PUMA BH3 peptide
Descriptor:	Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:	Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:	2012-10-19
Release date:	2013-01-30
Last modified:	2013-03-06
Method:	SOLUTION NMR
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

6UBI

N123-VRC34.05 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
Descriptor:	HIV fusion peptide 512-519, VRC34.05 heavy chain, VRC34.05 light chain
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2019-09-11
Release date:	2020-03-18
Last modified:	2020-04-22
Method:	X-RAY DIFFRACTION (1.903 Å)
Cite:	VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage. Cell Host Microbe, 27, 2020

6UCE

N123-VRC34_pI3 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
Descriptor:	HIV fusion peptide, N123-VRC34_pI3 heavy chain, N123-VRC34_pI3 light chain
Authors:	Xu, K, Kwong, P.D.
Deposit date:	2019-09-16
Release date:	2020-03-18
Last modified:	2020-04-22
Method:	X-RAY DIFFRACTION (1.382 Å)
Cite:	VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage. Cell Host Microbe, 27, 2020

6UCF

N123-VRC34_pI4 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
Descriptor:	HIV fusion peptide, N123-VRC34_pI4 heavy chain, N123-VRC34_pI4 light chain
Authors:	Xu, K, Kwong, P.D.
Deposit date:	2019-09-16
Release date:	2020-03-18
Last modified:	2020-04-22
Method:	X-RAY DIFFRACTION (1.29 Å)
Cite:	VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage. Cell Host Microbe, 27, 2020

7LKB

Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.127
Descriptor:	Circumsporozoite protein, SULFATE ION, m42.127 Fab heavy Chain, ...
Authors:	Xu, K, Kwong, P.D.
Deposit date:	2021-02-02
Release date:	2021-12-15
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Immunity, 54, 2021

7LKG

Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.151
Descriptor:	Circumsporozoite protein, m43.151 Fab Heavy Chain, m43.151 Fab Light chain
Authors:	Xu, K, Kwong, P.D.
Deposit date:	2021-02-02
Release date:	2021-12-15
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Immunity, 54, 2021

7MTE

Structure of SARS-CoV-2 S2P spike at pH 7.4 refolded by low-pH treatment
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Tsybovsky, Y, Olia, A.S, Kwong, P.D.
Deposit date:	2021-05-13
Release date:	2021-09-15
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity. J.Biol.Chem., 297, 2021

7MTD

Structure of aged SARS-CoV-2 S2P spike at pH 7.4
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Tsybovsky, Y, Olia, A.S, Kwong, P.D.
Deposit date:	2021-05-13
Release date:	2021-09-15
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity. J.Biol.Chem., 297, 2021

7MTC

Structure of freshly purified SARS-CoV-2 S2P spike at pH 7.4
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Tsybovsky, Y, Olia, A.S, Kwong, P.D.
Deposit date:	2021-05-13
Release date:	2021-09-15
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (2.6 Å)
Cite:	SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity. J.Biol.Chem., 297, 2021

5TKJ

Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide residue 512-519, SULFATE ION, vFP1.01 chimeric mouse antibody heavy chain, ...
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2016-10-06
Release date:	2018-04-04
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.118 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

5TKK

Structure of mouse vaccination-elicited HIV neutralizing antibody vFP5.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide residue 512-519, mouse antibody vFP5.01 heavy chain, mouse antibody vFP5.01 light chain
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2016-10-06
Release date:	2018-04-04
Last modified:	2018-06-27
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

8EKA

Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(class 2)
Descriptor:	Circumsporozoite protein, L9 Fab heavy chain, L9 Fab light chain
Authors:	Tripathi, P, Kwong, P.D.
Deposit date:	2022-09-20
Release date:	2023-03-15
Last modified:	2023-09-27
Method:	ELECTRON MICROSCOPY (3.7 Å)
Cite:	Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope. Structure, 31, 2023

8EK1

Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class)
Descriptor:	Circumsporozoite protein, L9 Fab heavy chain, L9 Fab light chain
Authors:	Tripathi, P, Kwong, P.D.
Deposit date:	2022-09-19
Release date:	2023-03-15
Last modified:	2023-09-27
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope. Structure, 31, 2023

8T5C

Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 8.11G Heavy Chain, 8.11G Light Chain, ...
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2023-06-13
Release date:	2024-01-03
Last modified:	2024-01-24
Method:	ELECTRON MICROSCOPY (4.7 Å)
Cite:	Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability. Nat Commun, 15, 2024

7LZE

Cryo-EM Structure of disulfide stabilized HMPV F v4-B
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2021-03-09
Release date:	2021-08-25
Last modified:	2021-10-06
Method:	ELECTRON MICROSCOPY (3.23 Å)
Cite:	Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses. Proc.Natl.Acad.Sci.USA, 118, 2021

6MQE

Vaccine-elicited NHP FP-targeting HIV neutralizing antibody DFPH-a.15 in complex with HIV fusion peptide (residue 512-519)
Descriptor:	DFPHa.15 antibody Fab heavy chain, DFPHa.15 antibody Fab light chain, HIV fusion peptide
Authors:	Xu, K, Wang, Y, Kwong, P.D.
Deposit date:	2018-10-09
Release date:	2019-07-31
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.459 Å)
Cite:	Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019

6MQS

Vaccine-elicited NHP FP-targeting HIV neutralizing antibody A12V163-a.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor:	HIV fusion peptide residue 512-519, antibody A12V163-a.01 heavy chain, antibody A12V163-a.01 light chain
Authors:	Xu, K, Wang, Y, Kwong, P.D.
Deposit date:	2018-10-10
Release date:	2019-07-31
Last modified:	2019-11-13
Method:	X-RAY DIFFRACTION (2.997 Å)
Cite:	Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019

6NF2

Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
Descriptor:	0PV-c.01 Heavy Chain, 0PV-c.01 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2018-12-18
Release date:	2019-07-24
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (3.7 Å)
Cite:	Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019

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