7LKB
Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.127
Summary for 7LKB
Entry DOI | 10.2210/pdb7lkb/pdb |
Descriptor | m42.127 Fab heavy Chain, m42.127 Fab light chain, Circumsporozoite protein, ... (5 entities in total) |
Functional Keywords | malaria, csp, junction region, antibody, m42.127, immune system, immune system-antigen complex, immune system/antigen |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 102239.75 |
Authors | Xu, K.,Kwong, P.D. (deposition date: 2021-02-02, release date: 2021-12-15, Last modification date: 2023-10-18) |
Primary citation | Kratochvil, S.,Shen, C.H.,Lin, Y.C.,Xu, K.,Nair, U.,Da Silva Pereira, L.,Tripathi, P.,Arnold, J.,Chuang, G.Y.,Melzi, E.,Schon, A.,Zhang, B.,Dillon, M.,Bonilla, B.,Flynn, B.J.,Kirsch, K.H.,Kisalu, N.K.,Kiyuka, P.K.,Liu, T.,Ou, L.,Pancera, M.,Rawi, R.,Reveiz, M.,Seignon, K.,Wang, L.T.,Waring, M.T.,Warner, J.,Yang, Y.,Francica, J.R.,Idris, A.H.,Seder, R.A.,Kwong, P.D.,Batista, F.D. Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Immunity, 54:2859-2876.e7, 2021 Cited by PubMed: 34788599DOI: 10.1016/j.immuni.2021.10.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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