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1EVY
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE
Descriptor:GLYCEROL-3-PHOSPHATE DEHYDROGENASE, PENTADECANE
Authors:Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A.M., Hol, W.G.J.
Deposit date:2000-04-20
Release date:2001-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des., 8, 2000
1EVZ
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH NAD
Descriptor:GLYCEROL-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PENTADECANE
Authors:Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A.M., Hol, W.G.J.
Deposit date:2000-04-21
Release date:2001-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des., 8, 2000
1IIG
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STRUCTURE OF TRYPANOSOMA BRUCEI BRUCEI TRIOSEPHOSPHATE ISOMERASE COMPLEXED WITH 3-PHOSPHONOPROPIONATE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 3-PHOSPHONOPROPANOIC ACID
Authors:Noble, M.E., Wierenga, R.K., Lambeir, A.M., Opperdoes, F.R., Thunnissen, A.M., Kalk, K.H., Groendijk, H., Hol, W.G.J.
Deposit date:2001-04-23
Release date:2001-05-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1IIH
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STRUCTURE OF TRYPANOSOMA BRUCEI BRUCEI TRIOSEPHOSPHATE ISOMERASE COMPLEXED WITH 3-PHOSPHOGLYCERATE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 3-PHOSPHOGLYCERIC ACID
Authors:Noble, M.E., Wierenga, R.K., Lambeir, A.M., Opperdoes, F.R., Thunnissen, A.M., Kalk, K.H., Groendijk, H., Hol, W.G.J.
Deposit date:2001-04-23
Release date:2001-05-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1TSI
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STRUCTURE OF THE COMPLEX BETWEEN TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AND N-HYDROXY-4-PHOSPHONO-BUTANAMIDE: BINDING AT THE ACTIVE SITE DESPITE AN "OPEN" FLEXIBLE LOOP
Descriptor:TRIOSEPHOSPHATE ISOMERASE, N-HYDROXY-4-PHOSPHONO-BUTANAMIDE
Authors:Verlinde, C.L.M.J.
Deposit date:1992-11-19
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation.
Protein Sci., 1, 1992
6TIM
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THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SN-GLYCEROL-3-PHOSPHATE
Authors:Noble, M.E.M., Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
3TIM
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THE CRYSTAL STRUCTURE OF THE "OPEN" AND THE "CLOSED" CONFORMATION OF THE FLEXIBLE LOOP OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE
Descriptor:TRIOSEPHOSPHATE ISOMERASE
Authors:Wierenga, R.K.
Deposit date:1990-05-15
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase.
Proteins, 10, 1991
4TIM
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CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 2-PHOSPHOGLYCERIC ACID
Authors:Nobel, M.E.M., Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-11
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.
J.Med.Chem., 34, 1991
5TIM
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REFINED 1.83 ANGSTROMS STRUCTURE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, CRYSTALLIZED IN THE PRESENCE OF 2.4 M-AMMONIUM SULPHATE. A COMPARISON WITH THE STRUCTURE OF THE TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE-GLYCEROL-3-PHOSPHATE COMPLEX
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SULFATE ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.
J.Mol.Biol., 220, 1991
1GYQ
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CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD
Descriptor:PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE), N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Suresh, S., Hol, W.
Deposit date:1999-03-05
Release date:1999-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Proc.Natl.Acad.Sci.USA, 96, 1999
2X0N
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STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM TRYPANOSOMA BRUCEI DETERMINED FROM LAUE DATA
Descriptor:GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GLYCOSOMAL, SULFATE ION, ...
Authors:Vellieux, F.M.D., Hajdu, J., Hol, W.G.J.
Deposit date:2009-12-16
Release date:2009-12-22
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma Brucei Determined from Laue Data.
Proc.Natl.Acad.Sci.USA, 90, 1993
1AMK
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LEISHMANIA MEXICANA TRIOSE PHOSPHATE ISOMERASE
Descriptor:TRIOSE PHOSPHATE ISOMERASE, 2-PHOSPHOGLYCOLIC ACID
Authors:Williams, J.C., Wierenga, R.
Deposit date:1997-06-17
Release date:1997-12-17
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural and mutagenesis studies of leishmania triosephosphate isomerase: a point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power.
Protein Eng., 12, 1999