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6VJL
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BU of 6vjl by Molmil
Streptavidin mutant M112 (G26C/A46C)
Descriptor: BIOTIN, Streptavidin
Authors:Marangoni, J.M, Wu, S.C, Fogen, D, Wong, S.L, Ng, K.K.S.
Deposit date:2020-01-16
Release date:2020-12-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity.
Sci Rep, 10, 2020
4ATO
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BU of 4ato by Molmil
New insights into the mechanism of bacterial Type III toxin-antitoxin systems: selective toxin inhibition by a non-coding RNA pseudoknot
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, TOXI, TOXN
Authors:Short, F.L, Pei, X.Y, Blower, T.R, Ong, S.L, Luisi, B.F, Salmond, G.P.C.
Deposit date:2012-05-09
Release date:2012-12-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selectivity and Self-Assembly in the Control of a Bacterial Toxin by an Antitoxic Noncoding RNA Pseudoknot.
Proc.Natl.Acad.Sci.USA, 110, 2013
8BLT
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BU of 8blt by Molmil
Structure of Lactobacillus salivarius (Ls) bile salt hydrolase(BSH) in complex with taurocholate (TCA)
Descriptor: Bile salt hydrolase, TAUROCHOLIC ACID
Authors:Karlov, D.S, Long, S.L, Zeng, X, Xu, F, Lal, K, Cao, L, Hayoun, K, Lin, J, Joyce, S.A, Tikhonova, I.G.
Deposit date:2022-11-10
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses.
Structure, 31, 2023
8BLS
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BU of 8bls by Molmil
Structure of Lactobacillus salivarius (Ls) bile salt hydrolase(BSH) in complex with Glycocholate (GCA)
Descriptor: Bile salt hydrolase, GLYCOCHOLIC ACID
Authors:Karlov, D.S, Long, S.L, Zeng, X, Xu, F, Lal, K, Cao, L, Hayoun, K, Lin, J, Joyce, S.A, Tikhonova, I.G.
Deposit date:2022-11-10
Release date:2023-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses.
Structure, 31, 2023
4EKV
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BU of 4ekv by Molmil
Streptavidin 8-aa-loop H127C mutein with reversible biotin binding
Descriptor: BIOTIN, CHLORIDE ION, Streptavidin
Authors:Barrette-Ng, I.H, Honetschlaeger, C, Wong, S.L, Ng, K.K.S.
Deposit date:2012-04-09
Release date:2012-06-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of a tetrameric streptavidin mutein with reversible biotin binding capability: engineering a mobile loop as an exit door for biotin.
Plos One, 7, 2012
4JO6
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BU of 4jo6 by Molmil
Streptavidin complex with SBP-Tag
Descriptor: SBP-Tag, Streptavidin
Authors:Barrette-Ng, I.H, Wu, S.C, Tjia, W.M, Wong, S.L, Ng, K.K.S.
Deposit date:2013-03-17
Release date:2013-05-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits
Acta Crystallogr.,Sect.D, 69, 2013
7UI0
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BU of 7ui0 by Molmil
Post-fusion ectodomain of HSV-1 gB in complex with HSV010-13 Fab
Descriptor: Envelope glycoprotein B, HSV10-13 Fab Heavy chain, HSV10-13 Light chain
Authors:Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C.
Deposit date:2022-03-28
Release date:2023-02-08
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice.
J.Clin.Invest., 133, 2023
7UHZ
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BU of 7uhz by Molmil
Post-fusion ectodomain of HSV-1 gB in complex with BMPC-23 Fab
Descriptor: BMPC-23 Fab Heavy chain, BMPC-23 Fab Light chain, Envelope glycoprotein B
Authors:Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C.
Deposit date:2022-03-28
Release date:2023-02-08
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice.
J.Clin.Invest., 133, 2023
6VJK
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BU of 6vjk by Molmil
Streptavidin mutant M88 (N49C/A86C)
Descriptor: BIOTIN, Streptavidin
Authors:Marangoni, J.M, Wu, S.C, Fogen, D, Wong, S.L, Ng, K.K.S.
Deposit date:2020-01-16
Release date:2020-12-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity.
Sci Rep, 10, 2020
1MAZ
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BU of 1maz by Molmil
X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH
Descriptor: Bcl-2-like protein 1
Authors:Muchmore, S.W, Sattler, M, Liang, H, Meadows, R.P, Harlan, J.E, Yoon, H.S, Nettesheim, D, Chang, B.S, Thompson, C.B, Wong, S.L, Ng, S.C, Fesik, S.W.
Deposit date:1996-04-09
Release date:1997-04-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1LXL
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BU of 1lxl by Molmil
NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE
Descriptor: BCL-XL
Authors:Muchmore, S.W, Sattler, M, Liang, H, Meadows, R.P, Harlan, J.E, Yoon, H.S, Nettesheim, D, Chang, B.S, Thompson, C.B, Wong, S.L, Ng, S.C, Fesik, S.W.
Deposit date:1996-04-04
Release date:1997-04-21
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1OSS
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BU of 1oss by Molmil
T190P STREPTOMYCES GRISEUS TRYPSIN IN COMPLEX WITH BENZAMIDINE
Descriptor: BENZAMIDINE, CALCIUM ION, SULFATE ION, ...
Authors:Page, M.J, Wong, S.L, Hewitt, J, Strynadka, N.C, MacGillivray, R.T.
Deposit date:2003-03-20
Release date:2003-08-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Engineering the Primary Substrate Specificity of Streptomyces griseus Trypsin.
Biochemistry, 42, 2003
1OS8
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BU of 1os8 by Molmil
RECOMBINANT STREPTOMYCES GRISEUS TRYPSIN
Descriptor: CALCIUM ION, SULFATE ION, trypsin
Authors:Page, M.J, Wong, S.L, Hewitt, J, Strynadka, N.C, MacGillivray, R.T.
Deposit date:2003-03-18
Release date:2003-08-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Engineering the Primary Substrate Specificity of Streptomyces griseus Trypsin.
Biochemistry, 42, 2003
2KZT
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BU of 2kzt by Molmil
Structure of the Tandem MA-3 Region of Pdcd4
Descriptor: Programmed cell death protein 4
Authors:Waters, L.C, Strong, S.L, Oka, O, Muskett, F.W, Veverka, V, Banerjee, S, Schmedt, T, Henry, A.J, Klempnauer, K.H, Carr, M.D.
Deposit date:2010-06-24
Release date:2011-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
J.Biol.Chem., 286, 2011
8XB0
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BU of 8xb0 by Molmil
Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 292
Descriptor: 1,2-ETHANEDIOL, 7-chloranyl-5-(2-cyclopropylpyridin-3-yl)-8-fluoranyl-2-methyl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ...
Authors:Tong, S.L, Zhang, G.P.
Deposit date:2023-12-05
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.
J.Med.Chem., 67, 2024
8ROO
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BU of 8roo by Molmil
Crystal structure of HLA B*18:01 in complex with YERMCNIL, an 8-mer epitope from Influenza A
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, Influenza A derived peptide/Nucleoprotein, ...
Authors:Murdolo, L.D, Maddumage, J.C, Gras, S.
Deposit date:2024-01-11
Release date:2024-05-08
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes.
Clin Transl Immunology, 13, 2024
8ROP
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BU of 8rop by Molmil
Crystal structure of HLA B*18:01 in complex with QEIRTFSF, an 8-mer epitope from Influenza A
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ...
Authors:Murdolo, L.D, Maddumage, J.C, Gras, S.
Deposit date:2024-01-12
Release date:2024-05-08
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes.
Clin Transl Immunology, 13, 2024
8RNH
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BU of 8rnh by Molmil
Crystal structure of HLA B*18:01 in complex with EEIEITTHF, an 9-mer epitope from Influenza A
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
Authors:Murdolo, L.D, Maddumaage, J, Gras, S.
Deposit date:2024-01-10
Release date:2024-05-08
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes.
Clin Transl Immunology, 13, 2024
2M05
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BU of 2m05 by Molmil
Structure of module 2 from the E1 domain of C. elegans APL-1
Descriptor: Beta-amyloid-like protein
Authors:Hinds, M.G, Leong, S.
Deposit date:2012-10-20
Release date:2013-10-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function.
Metallomics, 6, 2013
8CDG
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BU of 8cdg by Molmil
Crystal structure of human IL-17A cytokine in complex with macrocycle
Descriptor: (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A
Authors:Schulze, M.-S.
Deposit date:2023-01-30
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Chem Sci, 14, 2023
7CKG
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BU of 7ckg by Molmil
Crystal structure of TMSiPheRS complexed with TMSiPhe
Descriptor: 4-(trimethylsilyl)-L-phenylalanine, Tyrosine--tRNA ligase
Authors:Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P.
Deposit date:2020-07-17
Release date:2021-03-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe.
Nat Commun, 11, 2020
7CKH
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BU of 7ckh by Molmil
Crystal structure of TMSiPheRS
Descriptor: Tyrosine--tRNA ligase
Authors:Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P.
Deposit date:2020-07-17
Release date:2021-03-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.79492676 Å)
Cite:DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe.
Nat Commun, 11, 2020
8XAR
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BU of 8xar by Molmil
Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 54
Descriptor: 1,2-ETHANEDIOL, 7-chloranyl-2-ethyl-5-pyridin-3-yl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ...
Authors:Zheng, J.Y, Zhang, G.P, Li, J.J, Tong, S.L.
Deposit date:2023-12-05
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.
J.Med.Chem., 67, 2024
3E17
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BU of 3e17 by Molmil
Crystal structure of the second PDZ domain from human Zona Occludens-2
Descriptor: Tight junction protein ZO-2
Authors:Chen, H, Tong, S.L, Teng, M.K, Niu, L.W.
Deposit date:2008-08-01
Release date:2009-07-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of the second PDZ domain from human zonula occludens 2
Acta Crystallogr.,Sect.F, 65, 2009
6KRG
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BU of 6krg by Molmil
Crystal structure of sfGFP Y182TMSiPhe
Descriptor: CHLORIDE ION, GLYCEROL, Green fluorescent protein, ...
Authors:Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P.
Deposit date:2019-08-21
Release date:2020-09-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe.
Nat Commun, 11, 2020

 

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