Author results

1NEG
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CRYSTAL STRUCTURE ANALYSIS OF N-AND C-TERMINAL LABELED SH3-DOMAIN OF ALPHA-CHICKEN SPECTRIN
Descriptor:Spectrin alpha chain, brain, AZIDE ION
Authors:Mueller, U., Buessow, K., Diehl, A., Niesen, F.H., Nyarsik, L., Heinemann, U.
Deposit date:2002-12-11
Release date:2003-01-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rapid purification and crystal structure analysis of a small protein carrying two terminal affinity tags
J.STRUCT.FUNCT.GENOM., 4, 2003
1SAW
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X-RAY STRUCTURE OF HOMO SAPIENS PROTEIN FLJ36880
Descriptor:hypothetical protein FLJ36880, MAGNESIUM ION, CHLORIDE ION
Authors:Manjasetty, B.A., Niesen, F.H., Delbrueck, H., Goetz, F., Sievert, V., Buessow, K., Behlke, J., Heinemann, U.
Deposit date:2004-02-09
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880.
Biol.Chem., 385, 2004
1U2H
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X-RAY STRUCTURE OF THE N-TERMINALLY TRUNCATED HUMAN APEP-1
Descriptor:Aortic preferentially expressed protein 1
Authors:Manjasetty, B.A., Scheich, C., Roske, Y., Niesen, F.H., Gotz, F., Bussow, K., Heinemann, U.
Deposit date:2004-07-19
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1)
Bmc Struct.Biol., 5, 2005
1Z57
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CRYSTAL STRUCTURE OF HUMAN CLK1 IN COMPLEX WITH 10Z-HYMENIALDISINE
Descriptor:Dual specificity protein kinase CLK1, DEBROMOHYMENIALDISINE
Authors:Debreczeni, J., Das, S., Knapp, S., Bullock, A., Guo, K., Amos, A., Fedorov, O., Edwards, A., Sundstrom, M., von Delft, F., Niesen, F.H., Ball, L., Sobott, F., Arrowsmith, C., Structural Genomics Consortium (SGC)
Deposit date:2005-03-17
Release date:2005-04-12
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2IW2
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CRYSTAL STRUCTURE OF HUMAN PROLIDASE
Descriptor:XAA-PRO DIPEPTIDASE, SODIUM ION
Authors:Mueller, U., Niesen, F.H., Roske, Y., Goetz, F., Behlke, J., Buessow, K., Heinemann, U.
Deposit date:2006-06-24
Release date:2006-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
To be Published
2J1L
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CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD
Descriptor:RHO-RELATED GTP-BINDING PROTEIN RHOD, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Pike, A.C.W., Johansson, C., Gileadi, C., Niesen, F.H., Sobott, F., Schoch, G., Elkins, J., Smee, C., Gorrec, F., Watt, S., Bray, J., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2006-08-14
Release date:2006-09-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Human Rho-Related GTP-Binding Protein Rhod
To be Published
2JAM
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G, POLYPEPTIDE, 1,2-ETHANEDIOL, ...
Authors:Debreczeni, J.E., Bullock, A., Keates, T., Niesen, F.H., Salah, E., Shrestha, L., Smee, C., Sobott, F., Pike, A.C.W., Bunkoczi, G., von Delft, F., Turnbull, A., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
Deposit date:2006-11-29
Release date:2007-03-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G
To be Published
2JC6
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE 1D
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1D, N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE
Authors:Debreczeni, J.E., Rellos, P., Fedorov, O., Niesen, F.H., Bhatia, C., Shrestha, L., Salah, E., Smee, C., Colebrook, S., Berridge, G., Gileadi, O., Bunkoczi, G., Ugochukwu, E., Pike, A.C.W., von Delft, F., Knapp, S., Sundstrom, M., Weigelt, J., Arrowsmith, C.H., Edwards, A.
Deposit date:2006-12-19
Release date:2007-02-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Calmodulin-Dependent Protein Kinase 1D
To be Published
2JIF
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STRUCTURE OF HUMAN SHORT-BRANCHED CHAIN ACYL-COA DEHYDROGENASE (ACADSB)
Descriptor:SHORT/BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE, COENZYME A PERSULFIDE, ...
Authors:Pike, A.C.W., Hozjan, V., Smee, C., Niesen, F.H., Kavanagh, K.L., Umeano, C., Turnbull, A.P., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Oppermann, U.
Deposit date:2007-02-28
Release date:2007-04-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Human Short-Branched Chain Acyl-Coa Dehydrogenase
To be Published
2OKN
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CRYSTAL STRCTURE OF HUMAN PROLIDASE
Descriptor:Xaa-Pro dipeptidase, MANGANESE (II) ION, HYDROGENPHOSPHATE ION
Authors:Mueller, U., Niesen, F.H., Roske, Y., Goetz, F., Behlke, J., Buessow, K., Heinemann, U., Protein Structure Factory (PSF)
Deposit date:2007-01-17
Release date:2007-02-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Human Prolidase: The Molecular Basis of PD Disease.
To be Published
2P0A
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THE CRYSTAL STRUCTURE OF HUMAN SYNAPSIN III (SYN3) IN COMPLEX WITH AMPPNP
Descriptor:Synapsin-3, CHLORIDE ION, SULFATE ION, ...
Authors:Turnbull, A.P., Phillips, C., Pike, A.C.W., Elkins, J.M., Gileadi, C., Salah, E., Niesen, F.H., Burgess, N., Gileadi, O., Gorrec, F., Umeano, C., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2007-02-28
Release date:2007-03-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of human synapsin III (SYN3) in complex with AMPPNP
To be Published
2UYY
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STRUCTURE OF THE CYTOKINE-LIKE NUCLEAR FACTOR N-PAC
Descriptor:N-PAC PROTEIN, POTASSIUM ION, [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
Authors:Tickle, J., Pilka, E.S., Bunkoczi, G., Berridge, G., Smee, C., Kavanagh, K.L., Hozjan, V., Niesen, F.H., Papagrigoriou, E., Pike, A.C.W., Turnbull, A., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., von Delft, F., Oppermann, U.
Deposit date:2007-04-20
Release date:2007-07-03
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of the Cytokine-Like Nuclear Factor N-Pac
To be Published
2GDZ
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CRYSTAL STRUCTURE OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE TYPE1, COMPLEXED WITH NAD+
Descriptor:NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Pilka, E.S., Guo, K., Kavanagh, K., Von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-03-17
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One, 5, 2010
1ONI
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CRYSTAL STRUCTURE OF A HUMAN P14.5, A TRANSLATIONAL INHIBITOR REVEALS DIFFERENT MODE OF LIGAND BINDING NEAR THE INVARIANT RESIDUES OF THE YJGF/UK114 PROTEIN FAMILY
Descriptor:14.5 kDa translational inhibitor protein, BENZOIC ACID
Authors:Manjasetty, B.A., Delbrueck, H., Mueller, U., Erdmann, M.F., Heinemann, U.
Deposit date:2003-02-28
Release date:2003-04-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Homo sapiens protein hp14.5.
Proteins, 54, 2004
1SZ7
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CRYSTAL STRUCTURE OF HUMAN BET3
Descriptor:Trafficking protein particle complex subunit 3, PALMITIC ACID
Authors:Turnbull, A.P., Prinz, B., Holz, C., Behlke, J., Schultchen, J., Delbrueck, H., Niesen, F.H., Lang, C., Heinemann, U.
Deposit date:2004-04-05
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization
Embo J., 24, 2005
1XCR
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CRYSTAL STRUCTURE OF LONGER SPLICE VARIANT OF PTD012 FROM HOMO SAPIENS REVEALS A NOVEL ZINC-CONTAINING FOLD
Descriptor:hypothetical protein PTD012, ZINC ION, ACETIC ACID
Authors:Manjasetty, B.A., Fieber-Erdmann, M., Roske, Y., Goetz, F., Buessow, K., Heinemann, U.
Deposit date:2004-09-03
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold
Protein Sci., 15, 2006
1ZV4
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 17 (RGSZ2)
Descriptor:Regulator of G-protein signaling 17
Authors:Schoch, G.A., Jansson, A., Elkins, J.M., Haroniti, A., Niesen, F.H., Bunkoczi, G., Lee, W.H., Turnbull, A.P., Yang, X., Sundstrom, M., Arrowsmith, C., Edwards, A., Marsden, B., Gileadi, O., Ball, L., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-06-01
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2EU9
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CRYSTAL STRUCTURE OF CLK3
Descriptor:Dual specificity protein kinase CLK3, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Rellos, P., Das, S., Ugochukwu, E., Turnbull, A., von Delft, F., Bunkoczi, G., Sobott, F., Bullock, A., Fedorov, O., Gileadi, C., Savitsky, P., Edwards, A., Aerrowsmith, C., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2005-10-28
Release date:2005-11-08
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2J51
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CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 5-AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO) -N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE- 1-CARBOTHIOAMIDE
Descriptor:STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., Debreczeni, J.E., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2006-09-08
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2J7T
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CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND TO SU11274
Descriptor:SERINE/THREONINE-PROTEIN KINASE 10, CALCIUM ION, ACETATE ION, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Das, S., Debreczeni, J., Sobott, F., Watt, S., Savitsky, P., Eswaran, J., Turnbull, A.P., Papagrigoriou, E., Ugochukwa, E., Gorrec, F., Umeano, C.C., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2006-10-17
Release date:2006-11-07
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2J90
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CRYSTAL STRUCTURE OF HUMAN ZIP KINASE IN COMPLEX WITH A TETRACYCLIC PYRIDONE INHIBITOR (PYRIDONE 6)
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE 3, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, CHLORIDE ION, ...
Authors:Turnbull, A.P., Berridge, G., Fedorov, O., Pike, A.C.W., Savitsky, P., Eswaran, J., Papagrigoriou, E., Ugochukwa, E., von Delft, F., Gileadi, O., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2006-10-31
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2JFL
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CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Descriptor:STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 1,2-ETHANEDIOL, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2007-02-02
Release date:2007-02-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2JFM
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CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)
Descriptor:STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2007-02-02
Release date:2007-02-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2KBY
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THE TETRAMERIZATION DOMAIN OF HUMAN P73
Descriptor:Tumor protein p73
Authors:Coutandin, D., Ikeya, T., Loehr, F., Guntert, P., Ou, H.D., Doetsch, V.
Deposit date:2008-12-12
Release date:2009-09-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformational stability and activity of p73 require a second helix in the tetramerization domain.
Cell Death Differ., 16, 2009
2P8U
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CRYSTAL STRUCTURE OF HUMAN 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE I
Descriptor:Hydroxymethylglutaryl-CoA synthase, cytoplasmic, COENZYME A, ...
Authors:Turnbull, A., Shafqat, N., Salah, E., Niesen, F.H., Burgess, N., Bunkoczi, G., Debreczeni, J., Pike, A.C.W., Umeano, C., Gorrec, F., von Delft, F., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-03-23
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
J.Mol.Biol., 398, 2010
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