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5HSI
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CRYSTAL STRUCTURE OF TYROSINE DECARBOXYLASE AT 1.73 ANGSTROMS RESOLUTION
Descriptor:Putative decarboxylase, MAGNESIUM ION
Authors:Ni, Y., Zhou, J., Zhu, H., Zhang, K.
Deposit date:2016-01-25
Release date:2016-09-21
Method:X-RAY DIFFRACTION (1.732 Å)
Cite:Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding
Sci Rep, 6, 2016
5HSJ
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STRUCTURE OF TYROSINE DECARBOXYLASE COMPLEX WITH PLP AT 1.9 ANGSTROMS RESOLUTION
Descriptor:Putative decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Ni, Y., Zhou, J., Zhu, H., Zhang, K.
Deposit date:2016-01-25
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding
Sci Rep, 6, 2016
5Z2X
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STRUCTURE OF ALCOHOL DEHYDROGENASE FROM KLUYVEROMYCES POLYSPORA(KPADH)
Descriptor:Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Wang, Y., Zhou, J.Y., Hou, X.D., Xu, G.C., Wu, L., Rao, Y.J., ZHou, J.H., Ni, Y.
Deposit date:2018-01-04
Release date:2019-01-02
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.
J. Am. Chem. Soc., 140, 2018
5ZEC
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CRYSTAL STRUCTURE OF KLUYVEROMYCES POLYSPORA ADH (KPADH) MUTANT (Q136N/F161V/S196G/E214G/S237C)
Descriptor:Uncharacterized protein ADH, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ...
Authors:Wang, Y., ZHou, J.Y., Hou, X.D., Xu, G.C., Rao, Y.J., Wu, L., Zhou, J.H., Ni, Y.
Deposit date:2018-02-27
Release date:2019-01-02
Method:X-RAY DIFFRACTION (1.779 Å)
Cite:Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.
J. Am. Chem. Soc., 140, 2018
5ZED
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CRYSTAL STRUCTURE OF KLUYVEROMYCES POLYSPORA ADH (KPADH) MUTANT (E214V/T215S)
Descriptor:Uncharacterized protein ADH, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wang, Y., Zhou, J.Y., Hou, X.D., Xu, G.C., Wu, L., Rao, Y.J., ZHou, J.H., Ni, Y.
Deposit date:2018-02-27
Release date:2019-01-02
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.
J. Am. Chem. Soc., 140, 2018
3SNI
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HIGHLY POTENT, SELECTIVE, AND ORALLY ACTIVE PHOSPHODIESTARASE 10A INHIBITORS
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
Authors:Malamas, M.S., Ni, Y., Erdei, J., Stange, H., Schindler, R., Lankau, H.-J., Grunwald, C., Fan, K.Y., Parris, K.D., Langen, B., Egerland, U., Hage, T., Marquis, K.L., Grauer, S., Brennan, J., Navarra, R., Graf, R., Harrison, B.L., Robichaud, A., Kronbach, T., Pangalos, M., Hofgen, N., Brandon, N.J.
Deposit date:2011-06-29
Release date:2011-10-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors.
J.Med.Chem., 54, 2011
3SNL
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HIGHLY POTENT, SELECTIVE, AND ORALLY ACTIVE PHOSPHODIESTARASE 10A INHIBITORS
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
Authors:Malamas, M.S., Ni, Y., Erdei, J., Stange, H., Schindler, R., Lankau, H.-J., Grunwald, C., Fan, K.Y., Parris, K.D., Langen, B., Egerland, U., Hage, T., Marquis, K.L., Grauer, S., Brennan, J., Navarra, R., Graf, R., Harrison, B.L., Robichaud, A., Kronbach, T., Pangalos, M., Hofgen, N., Brandon, N.J.
Deposit date:2011-06-29
Release date:2011-10-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors.
J.Med.Chem., 54, 2011
1EQ2
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THE CRYSTAL STRUCTURE OF ADP-L-GLYCERO-D-MANNOHEPTOSE 6-EPIMERASE
Descriptor:ADP-L-GLYCERO-D-MANNOHEPTOSE 6-EPIMERASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Deacon, A.M., Ni, Y.S., Coleman Jr., W.G., Ealick, S.E.
Deposit date:2000-03-31
Release date:2000-11-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist.
Structure Fold.Des., 8, 2000
3P5B
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THE STRUCTURE OF THE LDLR/PCSK9 COMPLEX REVEALS THE RECEPTOR IN AN EXTENDED CONFORMATION
Descriptor:Proprotein convertase subtilisin/kexin type 9, Low density lipoprotein receptor variant, CALCIUM ION
Authors:Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y., Hubbard, B., Sitlani, A., Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
3P5C
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THE STRUCTURE OF THE LDLR/PCSK9 COMPLEX REVEALS THE RECEPTOR IN AN EXTENDED CONFORMATION
Descriptor:Proprotein convertase subtilisin/kexin type 9, Low density lipoprotein receptor variant, CALCIUM ION
Authors:Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y., Hubbard, B., Sitlani, A., Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
3SN7
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HIGHLY POTENT, SELECTIVE, AND ORALLY ACTIVE PHOSPHODIESTARASE 10A INHIBITORS
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, CHLORIDE ION, 8-fluoro-6-methoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxaline, ...
Authors:Parris, K.D.
Deposit date:2011-06-28
Release date:2011-10-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors.
J.Med.Chem., 54, 2011
4FCB
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POTENT AND SELECTIVE PHOSPHODIESTERASE 10A INHIBITORS
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
Authors:Parris, K.D.
Deposit date:2012-05-24
Release date:2012-09-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4FCD
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POTENT AND SELECTIVE PHOSPHODIESTERASE 10A INHIBITORS
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
Authors:Parris, K.D.
Deposit date:2012-05-24
Release date:2012-09-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012