Author results

1IQ7
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OVOTRANSFERRIN, C-TERMINAL LOBE, APO FORM
Descriptor:Ovotransferrin, N-ACETYL-D-GLUCOSAMINE, SULFATE ION
Authors:Mizutani, K., Muralidhara, B.K., Yamashita, H., Tabata, S., Mikami, B., Hirose, M.
Deposit date:2001-07-06
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Anion-mediated Fe3+ release mechanism in ovotransferrin C-lobe: a structurally identified SO4(2-) binding site and its implications for the kinetic pathway.
J.Biol.Chem., 276, 2001
2BDM
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STRUCTURE OF CYTOCHROME P450 2B4 WITH BOUND BIFONAZOLE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-[PHENYL-(4-PHENYLPHENYL)-METHYL]IMIDAZOLE, ...
Authors:Zhao, Y., White, M.A., Muralidhara, B.K., Sun, L., Halpert, J.R., Stout, C.D.
Deposit date:2005-10-20
Release date:2005-12-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
J.Biol.Chem., 281, 2006
2Q6N
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STRUCTURE OF CYTOCHROME P450 2B4 WITH BOUND 1-(4-CHOLOROPHENYL)IMIDAZOLE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-(4-CHLOROPHENYL)-1H-IMIDAZOLE
Authors:Zhao, Y., Sun, L., Muralidhara, B.K., Kumar, S., White, M.A., Stout, C.D., Halpert, J.R.
Deposit date:2007-06-05
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Biochemistry, 46, 2007
3G5N
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TRIPLE LIGAND OCCUPANCY CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 IN COMPLEX WITH THE INHIBITOR 1-BIPHENYL-4-METHYL-1H-IMIDAZOLE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-(biphenyl-4-ylmethyl)-1H-imidazole, ...
Authors:Gay, S.C., Sun, L., Maekawa, K., Halpert, J.R., Stout, C.D.
Deposit date:2009-02-05
Release date:2009-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48, 2009
3G93
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SINGLE LIGAND OCCUPANCY CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 IN COMPLEX WITH THE INHIBITOR 1-BIPHENYL-4-METHYL-1H-IMIDAZOLE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-(biphenyl-4-ylmethyl)-1H-imidazole
Authors:Gay, S.C., Sun, L., Maekawa, K., Halpert, J.R., Stout, C.D.
Deposit date:2009-02-12
Release date:2009-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48, 2009
3KW4
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CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG TICLOPIDINE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, ticlopidine, ...
Authors:Gay, S.C., Maekawa, K., Roberts, A.G., Hong, W.-X., Zhang, Q., Stout, C.D., Halpert, J.R.
Deposit date:2009-11-30
Release date:2010-09-15
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.
Biochemistry, 49, 2010
3ME6
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CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG CLOPIDOGREL
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, Clopidogrel
Authors:Gay, S.C., Roberts, A.G., Maekawa, K., Talakad, J.C., Hong, W.X., Zhang, Q., Stout, C.D., Halpert, J.R.
Deposit date:2010-03-31
Release date:2010-09-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.
Biochemistry, 49, 2010
3MVR
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CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4-H226Y IN A CLOSED CONFORMATION
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE
Authors:Shah, M.B., Stout, C.D., Halpert, J.R.
Deposit date:2010-05-04
Release date:2010-09-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography.
J.Biol.Chem., 285, 2010
3R1A
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CLOSED CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 COVALENTLY BOUND TO THE MECHANISM-BASED INACTIVATOR TERT-BUTYLPHENYLACETYLENE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, (4-tert-butylphenyl)acetaldehyde
Authors:Gay, S.C., Zhang, H., Stout, C.D., Hollenberg, P.F., Halpert, J.R.
Deposit date:2011-03-09
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity.
Biochemistry, 50, 2011
3R1B
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OPEN CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 COVALENTLY BOUND TO THE MECHANISM-BASED INACTIVATOR TERT-BUTYLPHENYLACETYLENE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, (4-tert-butylphenyl)acetaldehyde, ...
Authors:Gay, S.C., Zhang, H., Stout, C.D., Hollenberg, P.F., Halpert, J.R.
Deposit date:2011-03-09
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity.
Biochemistry, 50, 2011
3TK3
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CYTOCHROME P450 2B4 MUTANT L437A IN COMPLEX WITH 4-(4-CHLOROPHENYL)IMIDAZOLE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE
Authors:Gay, S.C., Jang, H.H., Wilderman, P.R., Zhang, Q., Stout, C.D., Halpert, J.R.
Deposit date:2011-08-25
Release date:2011-11-16
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.8001 Å)
Cite:Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.
Febs J., 279, 2012
3UAS
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CYTOCHROME P450 2B4 COVALENTLY BOUND TO THE MECHANISM-BASED INACTIVATOR 9-ETHYNYLPHENANTHRENE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, phenanthren-9-ylacetaldehyde, ...
Authors:Gay, S.C., Zhang, H., Shah, M.B., Stout, C.D., Halpert, J.R., Hollenberg, P.F.
Deposit date:2011-10-21
Release date:2013-01-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.939 Å)
Cite:Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis.
Biochemistry, 52, 2013