Author results

1LXL
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NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE
Descriptor:BCL-XL
Authors:Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.L., Ng, S.C., Fesik, S.W.
Deposit date:1996-04-04
Release date:1997-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1MAZ
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X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH
Descriptor:Bcl-2-like protein 1
Authors:Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.L., Ng, S.C., Fesik, S.W.
Deposit date:1996-04-09
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1M4M
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MOUSE SURVIVIN
Descriptor:BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5, ZINC ION
Authors:Muchmore, S.W., Chen, J., Jakob, C., Zakula, D., Matayoshi, E.D., Wu, W., Zhang, H., Li, F., Ng, S.C., Altieri, D.C.
Deposit date:2002-07-03
Release date:2002-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN
MOL.CELL, 6, 2000
2I6A
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HUMAN ADENOSINE KINASE IN COMPLEX WITH 5'-DEOXY-5-IODOTUBERCIDIN
Descriptor:Adenosine kinase, 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE
Authors:Muchmore, S.W.
Deposit date:2006-08-28
Release date:2007-01-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
J.Med.Chem., 49, 2006
2I6B
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HUMAN ADENOSINE KINASE IN COMPLEX WITH AN ACETYLINIC INHIBITOR
Descriptor:Adenosine kinase, 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE
Authors:Muchmore, S.W.
Deposit date:2006-08-28
Release date:2007-01-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
J.Med.Chem., 49, 2006
1NL4
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CRYSTAL STRUCTURE OF RAT FARNESYL TRANSFERASE IN COMPLEX WITH A POTENT BIPHENYL INHIBITOR
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Curtin, M.L., Florjancic, A.S., Cohen, J., Gu, W.-J., Frost, D.J., Muchmore, S.W., Sham, H.L.
Deposit date:2003-01-06
Release date:2003-02-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel and Selective Imidazole-containing Biphenyl Inhibitors of Protein Farnesyltransferase
BIOORG.MED.CHEM.LETT., 13, 2003
1PPA
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THE CRYSTAL STRUCTURE OF A LYSINE 49 PHOSPHOLIPASE A2 FROM THE VENOM OF THE COTTONMOUTH SNAKE AT 2.0 ANGSTROMS RESOLUTION
Descriptor:PHOSPHOLIPASE A2, ANILINE
Authors:Holland, D.R., Clancy, L.L., Muchmore, S.W., Rydel, T.J., Einspahr, H.M., Finzel, B.C., Heinrikson, R.L., Watenpaugh, K.D.
Deposit date:1991-10-29
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of a lysine 49 phospholipase A2 from the venom of the cottonmouth snake at 2.0-A resolution.
J.Biol.Chem., 265, 1990
1ZAP
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SECRETED ASPARTIC PROTEASE FROM C. ALBICANS
Descriptor:SECRETED ASPARTIC PROTEINASE, ZINC ION, N-ethyl-N-[(4-methylpiperazin-1-yl)carbonyl]-D-phenylalanyl-N-[(1S,2S,4R)-4-(butylcarbamoyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]-L-norleucinamide
Authors:Abad-Zapatero, C., Muchmore, S.W.
Deposit date:1996-01-16
Release date:1997-04-21
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents.
Protein Sci., 5, 1996
2ERC
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CRYSTAL STRUCTURE OF ERMC' A RRNA-METHYL TRANSFERASE
Descriptor:RRNA METHYL TRANSFERASE
Authors:Bussiere, D.E., Muchmore, S.W., Dealwis, C.G., Schluckebier, G., Abad-Zapatero, C.
Deposit date:1998-03-13
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.
Biochemistry, 37, 1998
1I1B
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-1BETA AT 2.0 ANGSTROMS RESOLUTION
Descriptor:INTERLEUKIN-1 BETA
Authors:Finzel, B.C., Watenpaugh, K.D., Einspahr, H.M.
Deposit date:1989-12-05
Release date:1990-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of recombinant human interleukin-1 beta at 2.0 A resolution.
J.Mol.Biol., 209, 1989
1HAN
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CRYSTAL STRUCTURE OF THE BIPHENYL-CLEAVING EXTRADIOL DIOXYGENASE FROM A PCB-DEGRADING PSEUDOMONAD
Descriptor:2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE, FE (III) ION, TERTIARY-BUTYL ALCOHOL
Authors:Han, S., Bolin, J.T.
Deposit date:1995-08-30
Release date:1995-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad.
Science, 270, 1995
2WJO
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HUMAN BACE (BETA SECRETASE) IN COMPLEX WITH CYCLOHEXANECARBOXYLIC ACID (2-(2-AM INO-6-PHENOXY-4H-QUINAZOLIN-3-YL)-2 -CYCLOHEXYL-ETHYL)- AMIDE
Descriptor:BETA-SECRETASE 1, 2-AMINO-3-{(1R)-1-CYCLOHEXYL-2-[(CYCLOHEXYLCARBONYL)AMINO]ETHYL}-6-PHENOXYQUINAZOLIN-3-IUM
Authors:Mathieu, M., Dupuy, A.S.
Deposit date:2009-05-28
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Shape and Medicinal Chemistry: A Perspective.
J.Med.Chem., 53, 2010
1KMY
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CRYSTAL STRUCTURE OF 2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE COMPLEXED WITH 2,3-DIHYDROXYBIPHENYL UNDER ANAEROBIC CONDITION
Descriptor:2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE, FE (II) ION, BIPHENYL-2,3-DIOL, ...
Authors:Han, S., Bolin, J.T.
Deposit date:2001-12-17
Release date:2002-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1,2-dioxygenase by t-butanol.
J.Biol.Chem., 273, 1998
1KND
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CRYSTAL STRUCTURE OF 2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE COMPLEXED WITH CATECHOL UNDER ANAEROBIC CONDITION
Descriptor:2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE, FE (II) ION, CATECHOL, ...
Authors:Han, S., Bolin, J.T.
Deposit date:2001-12-18
Release date:2002-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1,2-dioxygenase by t-butanol.
J.Biol.Chem., 273, 1998
1KNF
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CRYSTAL STRUCTURE OF 2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE COMPLEXED WITH 3-METHYL CATECHOL UNDER ANAEROBIC CONDITION
Descriptor:2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE, FE (II) ION, 3-METHYLCATECHOL, ...
Authors:Han, S., Bolin, J.T.
Deposit date:2001-12-18
Release date:2002-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1,2-dioxygenase by t-butanol.
J.Biol.Chem., 273, 1998
1QAM
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THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor:ERMC' METHYLTRANSFERASE, ACETATE ION
Authors:Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J., Abad-Zapatero, C.
Deposit date:1999-03-25
Release date:2000-03-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
J.Mol.Biol., 289, 1999
1QAN
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THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor:ERMC' METHYLTRANSFERASE, ACETATE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J., Abad-Zapatero, C.
Deposit date:1999-03-26
Release date:2000-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
J.Mol.Biol., 289, 1999
1QAO
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THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor:ERMC' METHYLTRANSFERASE, S-ADENOSYLMETHIONINE
Authors:Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J., Abad-Zapatero, C.
Deposit date:1999-03-26
Release date:2000-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
J.Mol.Biol., 289, 1999
1QAQ
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THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor:ERMC' RRNA METHYLTRANSFERASE, SINEFUNGIN
Authors:Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J., Abad-Zapatero, C.
Deposit date:1999-03-28
Release date:2000-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
J.Mol.Biol., 289, 1999