1NL4

Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor

Summary for 1NL4

DescriptorProtein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
Functional Keywordstransferase, prenyltransferase
Biological sourceRattus norvegicus (Norway rat)
Total number of polymer chains2
Total molecular weight83340.93
Authors
Curtin, M.L.,Florjancic, A.S.,Cohen, J.,Gu, W.-J.,Frost, D.J.,Muchmore, S.W.,Sham, H.L. (deposition date: 2003-01-06, release date: 2003-02-11, Last modification date: 2017-10-11)
Primary citation
Curtin, M.L.,Florjancic, A.S.,Cohen, J.,Gu, W.-J.,Frost, D.J.,Muchmore, S.W.,Sham, H.L.
Novel and Selective Imidazole-containing Biphenyl Inhibitors of Protein Farnesyltransferase
BIOORG.MED.CHEM.LETT., 13:1367-1371, 2003
PubMed: 12657284 (PDB entries with the same primary citation)
DOI: 10.1016/S0960-894X(03)00096-9
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers33 1.6% 7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
169117
PDB entries from 2020-09-23