1NL4
Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein farnesyltransferase alpha subunit | polymer | 312 | 37634.3 | 1 | UniProt (Q04631) Pfam (PF01239) In PDB | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha |
| 2 | B | Protein farnesyltransferase beta subunit | polymer | 401 | 44879.3 | 1 | UniProt (Q02293) Pfam (PF00432) In PDB | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | B | ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | non-polymer | 308.4 | 1 | Chemie (HFP) | |||
| 5 | B | 4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETHYL)-AMINO]-2-NAPHTHALEN-1-YL-BENZONITRILE | non-polymer | 453.5 | 1 | Chemie (FTL) |
Sequence modifications
A: 55 - 366 (UniProt: Q04631)
| PDB | External Database | Details |
|---|---|---|
| Thr 156 | Ile 156 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82513.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 827.3 | |
| All* | Total formula weight | 83340.9 |
