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2A4F
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SYNTHESIS AND ACTIVITY OF N-AXYL AZACYCLIC UREA HIV-1 PROTEASE INHIBITORS WITH HIGH POTENCY AGAINST MULTIPLE DRUG RESISTANT VIRAL STRAINS.
Descriptor:Pol polyprotein, (5R,6R)-5-BENZYL-6-HYDROXY-2,4-BIS(4-HYDROXY-3-METHOXYBENZYL)-1-[3-(4-HYDROXYPHENYL)PROPANOYL]-1,2,4-TRIAZEPAN-3-ONE
Authors:Zhao, C., Sham, H., Sun, M., Lin, S., Stoll, V., Stewart, K.D., Mo, H., Vasavanonda, S., Saldivar, A., McDonald, E.
Deposit date:2005-06-28
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains
Bioorg.Med.Chem.Lett., 15, 2005
1JLX
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AGGLUTININ IN COMPLEX WITH T-DISACCHARIDE
Descriptor:AGGLUTININ, BETA-D-GALACTOSE, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, ...
Authors:Transue, T.R., Smith, A.K., Mo, H., Goldstein, I.J., Saper, M.A.
Deposit date:1997-07-23
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin.
Nat.Struct.Biol., 4, 1997
1JLY
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CRYSTAL STRUCTURE OF AMARANTHUS CAUDATUS AGGLUTININ
Descriptor:AGGLUTININ
Authors:Transue, T.R., Smith, A.K., Mo, H., Goldstein, I.J., Saper, M.A.
Deposit date:1997-07-23
Release date:1997-12-03
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin.
Nat.Struct.Biol., 4, 1997
3GGA
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HIV PROTEASE INHIBITORS WITH PSEUDO-SYMMETRIC CORES
Descriptor:V-1 protease, methyl [(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-yl]carbamate
Authors:Stoll, V.S.
Deposit date:2009-02-27
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
J.Med.Chem., 52, 2009
3GGX
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HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS
Descriptor:V-1 protease, methyl [(1S)-1-{[(1R,3S,4S)-4-{[(2S)-3,3-dimethyl-2-{3-[(6-methylpyridin-2-yl)methyl]-2-oxo-2,3-dihydro-1H-imidazol-1-yl}butanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]carbamoyl}-2,2-dimethylpropyl]carbamate
Authors:Stoll, V.S.
Deposit date:2009-03-02
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
J.Med.Chem., 52, 2009
3S85
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DISCOVERY OF NEW HIV PROTEASE INHIBITORS WITH POTENTIAL FOR CONVENIENT DOSING AND REDUCED SIDE EFFECTS: A-790742 AND A-792611.
Descriptor:Protease/reverse transcriptase, methyl N-[(2S)-1-[[(2S,3S,5S)-5-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethyl-butanoyl]amino]-3-oxidanyl-6-phenyl-1-(4-pyridin-3-ylphenyl)hexan-2-yl]amino]-3,3-dimethyl-1-oxidanylidene-butan-2-yl]carbamate
Authors:DeGoey, D.A., Flosi, W.J., Grampovnik, D.J., Flentge, C.A.
Deposit date:2011-05-27
Release date:2012-04-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
J.Med.Chem., 52, 2009
3GGV
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HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS
Descriptor:V-1 protease, methyl [(1S)-1-{[(1R,3S,4S)-3-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]methyl}-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]carbamoyl}-2,2-dimethylpropyl]carbamate
Authors:Stoll, V.S.
Deposit date:2009-03-02
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
J.Med.Chem., 52, 2009
1QMO
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STRUCTURE OF FRIL, A LEGUME LECTIN THAT DELAYS HEMATOPOIETIC PROGENITOR MATURATION
Descriptor:MANNOSE BINDING LECTIN, FRIL, CALCIUM ION, ...
Authors:Hamelryck, T.W., Moore, J.G., Chrispeels, M., Loris, R., Wyns, L.
Deposit date:1999-10-04
Release date:1999-10-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The Role of Weak Protein-Protein Interactions in Multivalent Lectin-Carbohydrate Binding: Crystal Structure of Cross-Linked Fril
J.Mol.Biol., 299, 2000
1B9R
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TERPREDOXIN FROM PSEUDOMONAS SP.
Descriptor:PROTEIN (TERPREDOXIN), FE2/S2 (INORGANIC) CLUSTER
Authors:Mo, H., Pochapsky, S.S., Pochapsky, T.C.
Deposit date:1999-02-15
Release date:1999-05-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A model for the solution structure of oxidized terpredoxin, a Fe2S2 ferredoxin from Pseudomonas.
Biochemistry, 38, 1999
1I17
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NMR STRUCTURE OF MOUSE DOPPEL 51-157
Descriptor:PRION-LIKE PROTEIN
Authors:Mo, H., Moore, R.C., Cohen, F.E., Westaway, D., Prusiner, S.B., Wright, P.E., Dyson, H.J.
Deposit date:2001-01-31
Release date:2001-03-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Two different neurodegenerative diseases caused by proteins with similar structures.
Proc.Natl.Acad.Sci.USA, 98, 2001
1ZRR
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RESIDUAL DIPOLAR COUPLING REFINEMENT OF ACIREDUCTONE DIOXYGENASE FROM KLEBSIELLA
Descriptor:E-2/E-2' protein, NICKEL (II) ION
Authors:Pochapsky, T.C., Pochapsky, S.S., Ju, T., Hoefler, C., Liang, J.
Deposit date:2005-05-19
Release date:2005-12-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A refined model for the structure of acireductone dioxygenase from Klebsiella ATCC 8724 incorporating residual dipolar couplings
J.Biomol.NMR, 34, 2006
2KP8
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LIGAND BOUND TO A MODEL PEPTIDE THAT MIMICS THE OPEN FUSOGENIC FORM
Descriptor:Model peptide, 5-{[(4'-methoxybiphenyl-4-yl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid
Authors:Olejniczak, E.T.
Deposit date:2009-10-09
Release date:2010-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.
Bioorg.Med.Chem.Lett., 2009