3GGA
HIV Protease inhibitors with pseudo-symmetric cores
Summary for 3GGA
Entry DOI | 10.2210/pdb3gga/pdb |
Related | 1MUI 3GGV 3GGX |
Descriptor | V-1 protease, methyl [(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-yl]carbamate (3 entities in total) |
Functional Keywords | pseudo-symmetrical hiv protease inhibitors, hydrolase, protease |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 6 |
Total formula weight | 65526.40 |
Authors | Stoll, V.S. (deposition date: 2009-02-27, release date: 2009-05-26, Last modification date: 2024-02-21) |
Primary citation | Degoey, D.A.,Grampovnik, D.J.,Flentge, C.A.,Flosi, W.J.,Chen, H.J.,Yeung, C.M.,Randolph, J.T.,Klein, L.L.,Dekhtyar, T.,Colletti, L.,Marsh, K.C.,Stoll, V.,Mamo, M.,Morfitt, D.C.,Nguyen, B.,Schmidt, J.M.,Swanson, S.J.,Mo, H.,Kati, W.M.,Molla, A.,Kempf, D.J. 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects. J.Med.Chem., 52:2571-2586, 2009 Cited by PubMed: 19323562DOI: 10.1021/jm900044w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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