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3GGX

HIV Protease, pseudo-symmetric inhibitors

Summary for 3GGX
Entry DOI10.2210/pdb3ggx/pdb
Related3GGA 3GGV
DescriptorV-1 protease, methyl [(1S)-1-{[(1R,3S,4S)-4-{[(2S)-3,3-dimethyl-2-{3-[(6-methylpyridin-2-yl)methyl]-2-oxo-2,3-dihydro-1H-imidazol-1-yl}butanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]carbamoyl}-2,2-dimethylpropyl]carbamate (2 entities in total)
Functional Keywordshiv protease, pseudo-symmetric inhibitors, hydrolase, protease
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains8
Total formula weight89702.11
Authors
Stoll, V.S. (deposition date: 2009-03-02, release date: 2009-05-26, Last modification date: 2024-02-21)
Primary citationDegoey, D.A.,Grampovnik, D.J.,Flentge, C.A.,Flosi, W.J.,Chen, H.J.,Yeung, C.M.,Randolph, J.T.,Klein, L.L.,Dekhtyar, T.,Colletti, L.,Marsh, K.C.,Stoll, V.,Mamo, M.,Morfitt, D.C.,Nguyen, B.,Schmidt, J.M.,Swanson, S.J.,Mo, H.,Kati, W.M.,Molla, A.,Kempf, D.J.
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
J.Med.Chem., 52:2571-2586, 2009
Cited by
PubMed: 19323562
DOI: 10.1021/jm900044w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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