2KP8

Ligand bound to a model peptide that mimics the open fusogenic form

Summary for 2KP8

• Entry DOI: 10.2210/pdb2kp8/pdb
• Descriptor: Model peptide, 5-{[(4'-methoxybiphenyl-4-yl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid (2 entities in total)
• Functional Keywords: protein/ligand, unknown function
• Biological source: Escherichia coli
• Total number of polymer chains: 3
• Total formula weight: 25057.00

Authors

Olejniczak, E.T. (deposition date: 2009-10-09, release date: 2010-01-19, Last modification date: 2023-07-26)

• Primary citation: Stewart, K.D.,Huth, J.R.,Ng, T.I.,McDaniel, K.,Hutchinson, R.N.,Stoll, V.S.,Mendoza, R.R.,Matayoshi, E.D.,Carrick, R.,Mo, H.,Severin, J.,Walter, K.,Richardson, P.L.,Barrett, L.W.,Meadows, R.,Anderson, S.,Kohlbrenner, W.,Maring, C.,Kempf, D.J.,Molla, A.,Olejniczak, E.T.; Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.; Bioorg.Med.Chem.Lett., 20:612-617, 2010; PubMed: 20004576; DOI: 10.1016/j.bmcl.2009.11.076

Experimental method

SOLUTION NMR