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5UHY
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BU of 5uhy by Molmil
A Human Antibody Against Zika Virus Crosslinks the E Protein to Prevent Infection
Descriptor: ZV67 Fab chain 1, ZV67 Fab chain 2, envelope protein
Authors:Hasan, S.S, Miller, A, Sapparapu, G, Fernandez, E, Klose, T, Long, F, Fokine, A, Porta, J.C, Jiang, W, Diamond, M.S, Crowe Jr, J.E, Kuhn, R.J, Rossmann, M.G.
Deposit date:2017-01-12
Release date:2017-03-29
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:A human antibody against Zika virus crosslinks the E protein to prevent infection.
Nat Commun, 8, 2017
6H46
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BU of 6h46 by Molmil
Human KRAS in complex with darpin K13
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H.
Deposit date:2018-07-20
Release date:2019-04-24
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun, 10, 2019
6H47
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BU of 6h47 by Molmil
Human KRAS in complex with darpin K19
Descriptor: GTPase KRas, SULFATE ION, darpin K19
Authors:Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H.
Deposit date:2018-07-20
Release date:2019-04-24
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun, 10, 2019
1LVQ
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BU of 1lvq by Molmil
IC3 of CB1 Bound to G(alpha)i
Descriptor: Cannabinoid receptor 1
Authors:Ulfers, A.L, McMurry, J.L, Miller, A, Wang, L, Kendall, D.A, Mierke, D.F.
Deposit date:2002-05-29
Release date:2002-12-11
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity.
Protein Sci., 11, 2002
1LVR
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BU of 1lvr by Molmil
IC3 of CB1 (L431A,A432L) Bound to G(alpha)i
Descriptor: Cannabinoid receptor 1
Authors:Ulfers, A.L, McMurry, J.L, Miller, A, Wang, L, Kendall, D.A, Mierke, D.F.
Deposit date:2002-05-29
Release date:2002-12-11
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity.
Protein Sci., 11, 2002
6W2U
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BU of 6w2u by Molmil
Mayaro Virus glycoprotein E1 ectodomain and glycoportien E2 ectodomain asymmetric unit
Descriptor: Spike glycoprotein E1, Spike glycoprotein E2
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2020-03-08
Release date:2020-10-07
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Cell Host Microbe, 28, 2020
6F76
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BU of 6f76 by Molmil
Antibody derived (Abd-8) small molecule binding to KRAS.
Descriptor: 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline, GTPase KRas, MAGNESIUM ION, ...
Authors:Bery, N, Cruz-Migoni, A, Quevedo, C.E, Phillips, S.V.E, Carr, S, Rabbitts, T.H.
Deposit date:2017-12-07
Release date:2018-08-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Elife, 7, 2018
6FA3
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BU of 6fa3 by Molmil
Antibody derived (Abd-6) small molecule binding to KRAS.
Descriptor: DIMETHYL SULFOXIDE, GTPase KRas, MAGNESIUM ION, ...
Authors:Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H.
Deposit date:2017-12-15
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6FA2
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BU of 6fa2 by Molmil
Antibody derived (Abd-5) small molecule binding to KRAS.
Descriptor: 4-[2-(dimethylamino)ethoxy]-~{N}-[[(3~{R})-5-(6-methoxypyridin-2-yl)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide, GTPase KRas, MAGNESIUM ION, ...
Authors:Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H.
Deposit date:2017-12-15
Release date:2018-09-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6FA4
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BU of 6fa4 by Molmil
Antibody derived (Abd-7) small molecule binding to KRAS.
Descriptor: 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[4-[(dimethylamino)methyl]phenyl]-2-methoxy-pyridin-3-amine, GTPase KRas, MAGNESIUM ION, ...
Authors:Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H.
Deposit date:2017-12-15
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6EXR
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BU of 6exr by Molmil
CHEMOTAXIS PROTEIN CHEY FROM Pyrococcus horikoshiI
Descriptor: 120aa long hypothetical chemotaxis protein (CheY)
Authors:Paithankar, K.S, Enderle, M.E, Wirthensohn, D, Grininger, M, Oesterhelt, D.
Deposit date:2017-11-09
Release date:2018-12-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation.
Acta Crystallogr.,Sect.F, 75, 2019
6PBH
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BU of 6pbh by Molmil
Crystal Structure of HLA-A*68:01 in complex with NP145-156, a 12 mer influenza peptide
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-68 alpha chain, ...
Authors:Gras, S.
Deposit date:2019-06-13
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Challenging immunodominance of influenza-specific CD8+T cell responses restricted by the risk-associated HLA-A*68:01 allomorph.
Nat Commun, 10, 2019
7S8R
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BU of 7s8r by Molmil
Crystal Structure of HLA A*1101 in complex with SALEWIKNK, an 9-mer epitope from Influenza B
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ...
Authors:Nguyen, A.T, Szeto, C, Gras, S.
Deposit date:2021-09-19
Release date:2022-02-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people.
Plos Pathog., 18, 2022
7S8S
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BU of 7s8s by Molmil
Crystal Structure of HLA A*1101 in complex with RVLVNGTFLK, an 10-mer epitope from Influenza B
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ...
Authors:Nguyen, A.T, Szeto, C, Gras, S.
Deposit date:2021-09-19
Release date:2022-02-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people.
Plos Pathog., 18, 2022
7S8Q
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BU of 7s8q by Molmil
Crystal Structure of HLA A*1101 in complex with KTNGNAFIGK, an 10-mer epitope from Influenza B
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ...
Authors:Nguyen, A.T, Szeto, C, Gras, S.
Deposit date:2021-09-19
Release date:2022-02-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people.
Plos Pathog., 18, 2022
6VYV
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BU of 6vyv by Molmil
Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor: E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ...
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2020-02-27
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.33 Å)
Cite:Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Cell Host Microbe, 28, 2020
6W09
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BU of 6w09 by Molmil
Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor: E1 glycoprotein, E2 glycoprotein, E3, ...
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2020-02-29
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Cell Host Microbe, 28, 2020
6W1C
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BU of 6w1c by Molmil
Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor: E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ...
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2020-03-04
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Cell Host Microbe, 28, 2020
1BOY
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BU of 1boy by Molmil
EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR
Descriptor: HUMAN TISSUE FACTOR
Authors:Boys, C.W.G, Tuddenham, E.G.D, Harlos, K.
Deposit date:1996-01-11
Release date:1996-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the extracellular region of human tissue factor.
Nature, 370, 1994
7QI0
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BU of 7qi0 by Molmil
Crystal structure of KLK6 in complex with compound DKFZ918
Descriptor: (5~{R})-3-(6-carbamimidoylpyridin-3-yl)-~{N}-[(1~{S})-1-naphthalen-1-ylpropyl]-2-oxidanylidene-1,3-oxazolidine-5-carboxamide, Kallikrein-6
Authors:Jagtap, P.K.A, Baumann, A, Lohbeck, J, Isak, D, Miller, A, Hennig, J.
Deposit date:2021-12-14
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Scalable synthesis and structural characterization of reversible KLK6 inhibitors.
Rsc Adv, 12, 2022
7QHZ
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BU of 7qhz by Molmil
Crystal structure of KLK6 in complex with compound DKFZ917
Descriptor: (5~{R})-3-(4-carbamimidoylphenyl)-~{N}-[(1~{S})-1-naphthalen-1-ylpropyl]-2-oxidanylidene-1,3-oxazolidine-5-carboxamide, GLYCEROL, Kallikrein-6
Authors:Jagtap, P.K.A, Baumann, A, Lohbeck, J, Isak, D, Miller, A, Hennig, J.
Deposit date:2021-12-14
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Scalable synthesis and structural characterization of reversible KLK6 inhibitors.
Rsc Adv, 12, 2022
1EO6
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BU of 1eo6 by Molmil
CRYSTAL STRUCTURE OF GATE-16
Descriptor: GOLGI-ASSOCIATED ATPASE ENHANCER OF 16 KD
Authors:Paz, Y, Elazar, Z, Fass, D.
Deposit date:2000-03-22
Release date:2000-09-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p.
J.Biol.Chem., 275, 2000
5FBH
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BU of 5fbh by Molmil
Crystal structure of the extracellular domain of human calcium sensing receptor with bound Gd3+
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ...
Authors:Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J.
Deposit date:2015-12-14
Release date:2016-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2, 2016
5FBK
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BU of 5fbk by Molmil
Crystal structure of the extracellular domain of human calcium sensing receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ...
Authors:Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J.
Deposit date:2015-12-14
Release date:2016-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2, 2016
5N88
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BU of 5n88 by Molmil
Crystal structure of antibody bound to viral protein
Descriptor: PC4 and SFRS1-interacting protein, VH59 antibody
Authors:Bao, L, Hannon, C, Cruz-Migoni, A, Ptchelkine, D, Sun, M.-y, Derveni, M, Bunjobpol, W, Chambers, J.S, Simmons, A, Phillips, S.E.V, Rabbitts, T.H.
Deposit date:2017-02-23
Release date:2017-12-20
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.
Sci Rep, 7, 2017

 

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