6FA2

Antibody derived (Abd-5) small molecule binding to KRAS.

Summary for 6FA2

• Entry DOI: 10.2210/pdb6fa2/pdb
• Related: 5OCG 5OCO 5OCT 6F76
• Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (7 entities in total)
• Functional Keywords: abd-5, inhibitor, kras, oncoprotein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 122026.02

Authors

Quevedo, C.E.,Cruz-Migoni, A.,Ehebauer, M.T.,Carr, S.B.,Phillips, S.V.E.,Rabbitts, T.H. (deposition date: 2017-12-15, release date: 2018-09-05)

• Primary citation: Quevedo, C.E.,Cruz-Migoni, A.,Bery, N.,Miller, A.,Tanaka, T.,Petch, D.,Bataille, C.J.R.,Lee, L.Y.W.,Fallon, P.S.,Tulmin, H.,Ehebauer, M.T.,Fernandez-Fuentes, N.,Russell, A.J.,Carr, S.B.,Phillips, S.E.V.,Rabbitts, T.H.; Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.; Nat Commun, 9:3169-3169, 2018; PubMed: 30093669; DOI: 10.1038/s41467-018-05707-2

Experimental method

X-RAY DIFFRACTION (2.6 Å)