6FA2
Antibody derived (Abd-5) small molecule binding to KRAS.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTPase KRas | polymer | 167 | 19023.5 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | B, D, E, F | GTPase KRas | polymer | 170 | 19355.8 | 4 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
3 | C | GTPase KRas | polymer | 171 | 19519.0 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
4 | A, B, C, D, E... | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
5 | A, B, C, D, E... | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 6 | Chemie (GNP) | |||
6 | A, B, C, D, E... | 4-[2-(dimethylamino)ethoxy]-~{N}-[[(3~{R})-5-(6-methoxypyridin-2-yl)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide | non-polymer | 463.5 | 6 | Chemie (D2W) | |||
7 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A: 1 - 167 (UniProt: P01116)
B, D, E, F: 1 - 167 (UniProt: P01116)
C: 1 - 167 (UniProt: P01116)
PDB | External Database | Details |
---|---|---|
His 61 | Gln 61 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
His 61 | Gln 61 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
His 61 | Gln 61 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 115965.9 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 6060.2 | |
All* | Total formula weight | 122026.0 |