6F76

Antibody derived (Abd-8) small molecule binding to KRAS.

Summary for 6F76

Entry DOI	10.2210/pdb6f76/pdb
Descriptor	GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
Functional Keywords	abd-8, inhibitor, kras, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	122952.16
Authors	Bery, N.,Cruz-Migoni, A.,Quevedo, C.E.,Phillips, S.V.E.,Carr, S.,Rabbitts, T.H. (deposition date: 2017-12-07, release date: 2018-08-08)
Primary citation	Bery, N.,Cruz-Migoni, A.,Bataille, C.J.,Quevedo, C.E.,Tulmin, H.,Miller, A.,Russell, A.,Phillips, S.E.,Carr, S.B.,Rabbitts, T.H. BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife, 7:-, 2018 Cited by PubMed: 29989546 DOI: 10.7554/eLife.37122 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation