5UHY

A Human Antibody Against Zika Virus Crosslinks the E Protein to Prevent Infection

Summary for 5UHY

Entry DOI	10.2210/pdb5uhy/pdb
EMDB information	8548
Descriptor	ZV67 Fab chain 1, ZV67 Fab chain 2, envelope protein (3 entities in total)
Functional Keywords	flavivirus, zika, human antibody, therapeutic, virus-immune system complex, virus/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	7
Total formula weight	222837.55
Authors	Hasan, S.S.,Miller, A.,Sapparapu, G.,Fernandez, E.,Klose, T.,Long, F.,Fokine, A.,Porta, J.C.,Jiang, W.,Diamond, M.S.,Crowe Jr., J.E.,Kuhn, R.J.,Rossmann, M.G. (deposition date: 2017-01-12, release date: 2017-03-29, Last modification date: 2019-11-27)
Primary citation	Hasan, S.S.,Miller, A.,Sapparapu, G.,Fernandez, E.,Klose, T.,Long, F.,Fokine, A.,Porta, J.C.,Jiang, W.,Diamond, M.S.,Crowe, J.E.,Kuhn, R.J.,Rossmann, M.G. A human antibody against Zika virus crosslinks the E protein to prevent infection. Nat Commun, 8:14722-14722, 2017 Cited by PubMed: 28300075 DOI: 10.1038/ncomms14722 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (6.2 Å)

Structure validation