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1CWA
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X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Walkinshaw, M.D.
Deposit date:1995-09-06
Release date:1996-01-29
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray Structure of a Monomeric Cyclophilin A-Cyclosporin a Crystal Complex at 2.1 A Resolution.
J.Mol.Biol., 234, 1993
1CWB
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THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Walkinshaw, M.D.
Deposit date:1995-09-06
Release date:1996-01-29
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The X-Ray Structure of (Mebm2T)1-Cyclosporin Complexed with Cyclophilin a Provides an Explanation for its Anomalously High Immunosuppressive Activity.
Protein Eng., 7, 1994
1MIK
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THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V.
Deposit date:1995-09-20
Release date:1996-03-08
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-Cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis with Cyclophilin A.
J.Med.Chem., 38, 1995
1MIL
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TRANSFORMING PROTEIN
Descriptor:SHC ADAPTOR PROTEIN
Authors:Mikol, V.
Deposit date:1995-09-20
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data.
J.Mol.Biol., 254, 1995
1CYN
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CYCLOPHILIN B COMPLEXED WITH [D-(CHOLINYLESTER)SER8]-CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Walkinshaw, M.D.
Deposit date:1995-05-22
Release date:1996-01-29
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-Ray Structure of a Cyclophilin B/Cyclosporin Complex: Comparison with Cyclophilin a and Delineation of its Calcineurin-Binding Domain.
Proc.Natl.Acad.Sci.USA, 91, 1994
1A33
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PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI
Descriptor:PEPTIDYLPROLYL ISOMERASE
Authors:Mikol, V., Ma, D., Carlow, C.K.S.
Deposit date:1998-01-27
Release date:1998-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the cyclophilin-like domain from the parasitic nematode Brugia malayi.
Protein Sci., 7, 1998
1CWD
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HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE
Descriptor:P56LCK TYROSINE KINASE, (PHOSPHONOMETHYL)PHENYLALANINE-CONTAINING PEPTIDE PRO-GLU-GLY-ASP-PM3-GLU-GLU-VAL-LEU
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
1CWE
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HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE
Descriptor:P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-12-07
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
1CWO
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HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN C
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-06-05
Release date:1998-08-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Conformational Differences of an Immunosuppressant Peptolide in a Single Crystal and in a Crystal Complex with Human Cyclophilin A.
J.Mol.Biol., 283, 1998
1MIM
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IGG FAB FRAGMENT (CD25-BINDING)
Descriptor:CHIMERIC SDZ CHI621
Authors:Mikol, V.
Deposit date:1995-12-04
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the fab fragment of SDZ CHI621: a chimeric antibody against CD25.
Acta Crystallogr.,Sect.D, 52, 1996
1CWC
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IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-01-29
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Improved Binding Affinity for Cyclophilin a by a Cyclosporin Derivative Singly Modified at its Effector Domain.
J.Med.Chem., 37, 1994
1LQW
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CRYSTAL STRUCTURE OF S.AUREUS PEPTIDE DEFORMYLASE
Descriptor:PEPTIDE DEFORMYLASE PDF1, ZINC ION
Authors:Mikol, V.
Deposit date:2002-05-14
Release date:2002-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
1BCK
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN C
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-04-30
Release date:1998-09-16
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWF
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-04-30
Release date:1998-07-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWH
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HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-07
Release date:1998-07-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWI
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-25
Release date:1998-08-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWJ
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-25
Release date:1998-08-26
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWK
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HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-26
Release date:1998-07-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWL
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HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-26
Release date:1998-07-15
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWM
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HUMAN CYCLOPHILIN A COMPLEXED WITH 4 MEILE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-26
Release date:1998-07-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1LRU
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CRYSTAL STRUCTURE OF E.COLI PEPTIDE DEFORMYLASE COMPLEXED WITH ANTIBIOTIC ACTINONIN
Descriptor:PEPTIDE DEFORMYLASE, ZINC ION, ACTINONIN, ...
Authors:Guilloteau, J.-P., Mathieu, M., Giglione, C., Blanc, V., Dupuy, A., Chevrier, M., Gil, P., Famechon, A., Meinnel, T., Mikol, V.
Deposit date:2002-05-16
Release date:2002-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
1LRY
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CRYSTAL STRUCTURE OF P. AERUGINOSA PEPTIDE DEFORMYLASE COMPLEXED WITH ANTIBIOTIC ACTINONIN
Descriptor:PEPTIDE deformylase, ZINC ION, ACTINONIN
Authors:Guilloteau, J.-P., Mathieu, M., Giglione, C., Blanc, V., Dupuy, A., Chevrier, M., Gil, P., Famechon, A., Meinnel, T., Mikol, V.
Deposit date:2002-05-16
Release date:2002-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
4CP6
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THE CRYSTAL STRUCTURE OF PNEUMOCOCCAL VACCINE ANTIGEN PCPA
Descriptor:CHOLINE BINDING PROTEIN PCPA
Authors:Vallee, F., Steier, V., Oloo, E., Chawla, D., Vonrhein, C., Steinmetz, A., Mathieu, M., Rak, A., Mikol, V., Oomen, R.
Deposit date:2014-01-31
Release date:2015-02-25
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:The Crystal Structure of Pneumoccocal Vaccine Antigen Pcpa
To be Published
4UUQ
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CRYSTAL STRUCTURE OF HUMAN MONO-GLYCERIDE LIPASE IN COMPLEX WITH SAR127303
Descriptor:MONOGLYCERIDE LIPASE, 4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid
Authors:Griebel, G., Pichat, P., Beeske, S., Leroy, T., Redon, N., Francon, D., Bert, L., Even, L., Lopez-Grancha, M., Tolstykh, T., Sun, F., Yu, Q., Brittain, S., Arlt, H., He, T., Zhang, B., Wiederschain, D., Bertrand, T., Houtman, J., Rak, A., Vallee, F., Michot, N., Auge, F., Menet, V., Bergis, O.E., George, P., Avenet, P., Mikol, V., Didier, M., Escoubet, J.
Deposit date:2014-07-30
Release date:2015-01-21
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents.
Sci.Rep., 5, 2015
1LQY
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CRYSTAL STRUCTURE OF BACILLUS STEAROTHERMOPHILUS PEPTIDE DEFORMYLASE COMPLEXED WITH ANTIBIOTIC ACTINONIN
Descriptor:PEPTIDE deformylase 2, NICKEL (II) ION, ACTINONIN
Authors:Mathieu, M., Mikol, V.
Deposit date:2002-05-14
Release date:2002-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
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