1W78

E.coli FolC in complex with DHPP and ADP

Summary for 1W78

Entry DOI	10.2210/pdb1w78/pdb
Related	1W7K
Descriptor	FOLC BIFUNCTIONAL PROTEIN, PHOSPHORYLATED DIHYDROPTEROATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	folc, dhfs, dihydrofolate synthase, synthase, atp-binding, folate biosynthesis, ligase, multifunctional enzyme
Biological source	ESCHERICHIA COLI
Total number of polymer chains	1
Total formula weight	46463.68
Authors	Mathieu, M.,Debousker, G.,Vincent, S.,Viviani, F.,Bamas-Jacques, N.,Mikol, V. (deposition date: 2004-08-31, release date: 2005-02-09, Last modification date: 2023-12-13)
Primary citation	Mathieu, M.,Debousker, G.,Vincent, S.,Viviani, F.,Bamas-Jacques, N.,Mikol, V. Escherichia Coli Folc Structure Reveals an Unexpected Dihydrofolate Binding Site Providing an Attractive Target for Anti-Microbial Therapy J.Biol.Chem., 280:18916-, 2005 Cited by PubMed: 15705579 DOI: 10.1074/JBC.M413799200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation