1W78
E.coli FolC in complex with DHPP and ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004326 | molecular_function | tetrahydrofolylpolyglutamate synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0006761 | biological_process | dihydrofolate biosynthetic process |
| A | 0008841 | molecular_function | dihydrofolate synthase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016881 | molecular_function | acid-amino acid ligase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046901 | biological_process | tetrahydrofolylpolyglutamate biosynthetic process |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1422 |
| Chain | Residue |
| A | HIS173 |
| A | PD81421 |
| A | HOH2067 |
| A | HOH2256 |
| A | HOH2279 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1423 |
| Chain | Residue |
| A | HOH2217 |
| A | HOH2487 |
| A | SER83 |
| A | GLU146 |
| A | PD81421 |
| A | ADP1425 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1424 |
| Chain | Residue |
| A | LEU30 |
| A | GLY31 |
| A | LEU32 |
| A | GLU33 |
| A | ARG34 |
| A | HOH2039 |
| site_id | AC4 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE PD8 A 1421 |
| Chain | Residue |
| A | ILE28 |
| A | ASP29 |
| A | LEU30 |
| A | GLY31 |
| A | LYS60 |
| A | SER83 |
| A | PRO84 |
| A | THR122 |
| A | PHE124 |
| A | GLU125 |
| A | GLU146 |
| A | GLY148 |
| A | LEU153 |
| A | ASP154 |
| A | ALA155 |
| A | HIS173 |
| A | HIS305 |
| A | MG1422 |
| A | MG1423 |
| A | ADP1425 |
| A | HOH2029 |
| A | HOH2067 |
| A | HOH2105 |
| A | HOH2256 |
| A | HOH2279 |
| A | HOH2484 |
| A | HOH2485 |
| A | HOH2487 |
| A | HOH2488 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP A 1425 |
| Chain | Residue |
| A | THR57 |
| A | ASN58 |
| A | GLY59 |
| A | LYS60 |
| A | GLY61 |
| A | THR62 |
| A | GLU146 |
| A | ASN257 |
| A | ARG289 |
| A | ASP302 |
| A | VAL303 |
| A | ALA304 |
| A | HIS308 |
| A | ALA309 |
| A | TYR312 |
| A | PD81421 |
| A | MG1423 |
| A | HOH2217 |
| A | HOH2487 |
| A | HOH2488 |
| A | HOH2489 |
| A | HOH2490 |
Functional Information from PROSITE/UniProt
| site_id | PS01011 |
| Number of Residues | 24 |
| Details | FOLYLPOLYGLU_SYNT_1 Folylpolyglutamate synthase signature 1. FtVAGTNGKgTtcrtLeSILmaa.G |
| Chain | Residue | Details |
| A | PHE52-GLY75 |
| site_id | PS01012 |
| Number of Residues | 16 |
| Details | FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. ILEvGLGGrlDaTnIV |
| Chain | Residue | Details |
| A | ILE144-VAL159 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15705579, ECO:0007744|PDB:1W78 |
| Chain | Residue | Details |
| A | THR122 | |
| A | LEU153 | |
| A | ASP29 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15705579, ECO:0007744|PDB:1W78, ECO:0007744|PDB:1W7K |
| Chain | Residue | Details |
| A | ARG289 | |
| A | ASP302 | |
| A | GLY59 | |
| A | ASN257 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15705579 |
| Chain | Residue | Details |
| A | GLU146 | |
| A | HIS173 | |
| A | SER83 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:15705579 |
| Chain | Residue | Details |
| A | KCX188 |
