Author results

3UP3
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NUCLEAR RECEPTOR DAF-12 FROM HOOKWORM ANCYLOSTOMA CEYLANICUM IN COMPLEX WITH (25S)-CHOLESTENOIC ACID
Descriptor:aceDAF-12, Nuclear receptor coactivator 2, (8alpha,10alpha,25S)-3-hydroxycholesta-3,5-dien-26-oic acid, ...
Authors:Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E.
Deposit date:2011-11-17
Release date:2011-12-14
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes.
J.Biol.Chem., 287, 2012
3L3X
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CRYSTAL STRUCTURE OF DHT-BOUND ANDROGEN RECEPTOR IN COMPLEX WITH THE FIRST MOTIF OF STEROID RECEPTOR COACTIVATOR 3
Descriptor:Androgen receptor, Nuclear receptor coactivator 3, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Zhou, X.E., Suino-Powell, K.M., Li, J., He, A., MacKeigan, J.P., Melcher, K., Yong, E.-L., Xu, H.E.
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor.
J.Biol.Chem., 285, 2010
4IH1
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CRYSTAL STRUCTURE OF KARRIKIN INSENSITIVE 2 (KAI2) FROM ARABIDOPSIS THALIANA
Descriptor:Hydrolase, alpha/beta fold family protein
Authors:Zhou, X.E., Zhao, L.-H., Wu, Z.-S., Yi, W., Li, S., Li, Y., Xu, Y., Xu, T.-H., Liu, Y., Chen, R.-Z., Kovach, A., Kang, Y., Hou, L., He, Y., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2012-12-18
Release date:2013-01-30
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
4IH9
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CRYSTAL STRUCTURE OF RICE DWARF14 (D14)
Descriptor:Dwarf 88 esterase
Authors:Zhou, X.E., Zhao, L.-H., Wu, Z.-S., Yi, W., Li, S., Li, Y., Xu, Y., Xu, T.-H., Liu, Y., Chen, R.-Z., Kovach, A., Kang, Y., Hou, L., He, Y., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2012-12-18
Release date:2013-01-30
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
4IHA
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CRYSTAL STRUCTURE OF RICE DWARF14 (D14) IN COMPLEX WITH A GR24 HYDROLYSIS INTERMEDIATE
Descriptor:Dwarf 88 esterase, (2R,3R)-2,4,4-trihydroxy-3-methylbutanal
Authors:Zhou, X.E., Zhao, L.-H., Wu, Z.-S., Yi, W., Li, S., Li, Y., Xu, Y., Xu, T.-H., Liu, Y., Chen, R.-Z., Kovach, A., Kang, Y., Hou, L., He, Y., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2012-12-18
Release date:2013-01-23
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
3UP0
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NUCLEAR RECEPTOR DAF-12 FROM HOOKWORM ANCYLOSTOMA CEYLANICUM IN COMPLEX WITH (25S)-DELTA7-DAFACHRONIC ACID
Descriptor:aceDAF-12, Nuclear receptor coactivator 2, (5beta,14beta,17alpha,25S)-3-oxocholest-7-en-26-oic acid
Authors:Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E.
Deposit date:2011-11-17
Release date:2011-12-14
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes.
J.Biol.Chem., 287, 2012
4ME2
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CRYSTAL STRUCTURE OF THA8 PROTEIN FROM BRACHYPODIUM DISTACHYON
Descriptor:Uncharacterized protein
Authors:Ke, J., Chen, R.Z., Ban, T., Brunzelle, J.S., Gu, X., Melcher, K., Xu, H.E.
Deposit date:2013-08-24
Release date:2013-10-30
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for RNA recognition by a dimeric PPR-protein complex.
Nat.Struct.Mol.Biol., 20, 2013
3KAZ
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CRYSTAL STRUCTURE OF ABSCISIC ACID RECEPTOR PYL2
Descriptor:Putative uncharacterized protein At2g26040, 1,3-BUTANEDIOL
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Xu, H.E.
Deposit date:2009-10-19
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
3NMH
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CRYSTAL STRUCTURE OF THE ABSCISIC RECEPTOR PYL2 IN COMPLEX WITH PYRABACTIN
Descriptor:Abscisic acid receptor PYL2, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
3UC3
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THE CRYSTAL STRUCTURE OF SNF1-RELATED KINASE 2.3
Descriptor:Serine/threonine-protein kinase SRK2I, COBALT (II) ION
Authors:Zhou, X.E., Ng, L.-M., Soon, F.-F., Kovach, A., Suino-Powell, K.M., Li, J., Melcher, K., Xu, H.E.
Deposit date:2011-10-25
Release date:2011-12-14
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3UJK
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CRYSTAL STRUCTURE OF PROTEIN PHOSPHATASE ABI2
Descriptor:Protein phosphatase 2C 77, MAGNESIUM ION
Authors:Zhou, X.E., Soon, F.-F., Ng, L.-M., Kovach, A., Tan, M.H.E., Suino-Powell, K.M., He, Y., Xu, Y., Brunzelle, J.S., Li, J., Melcher, K., Xu, H.E.
Deposit date:2011-11-07
Release date:2012-02-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
Science, 335, 2012
4PW2
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5 EPIMERASE
Descriptor:D-glucuronyl C5 epimerase B, CITRIC ACID
Authors:Ke, J., Qin, Y., Gu, X., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-18
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
5TWO
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A NOVEL SELECTIVELY PPAR GAMMA-MODULATING LIGAND VSP-51
Descriptor:Peroxisome proliferator-activated receptor gamma, PRO-SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO, N-benzyl-1-[(4-chloro-3-fluorophenyl)methyl]-1H-indole-5-carboxamide
Authors:Yi, W., Shi, J., Zhao, G., Zhou, X.E., Suino-Powell, K., Melcher, K., Xu, H.E.
Deposit date:2016-11-14
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.927 Å)
Cite:Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro.
Sci Rep, 7, 2017
3KB0
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CRYSTAL STRUCTURE OF ABSCISIC ACID-BOUND PYL2
Descriptor:Putative uncharacterized protein At2g26040, (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Xu, H.E.
Deposit date:2009-10-19
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
3KB3
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CRYSTAL STRUCTURE OF ABSCISIC ACID-BOUND PYL2 IN COMPLEX WITH HAB1
Descriptor:Putative uncharacterized protein At2g26040, Protein phosphatase 2C 16, (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ...
Authors:Zhou, X.E., Melcher, K., Soon, F.-F., Ng, L.-M., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Xu, H.E.
Deposit date:2009-10-20
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
4RS9
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STRUCTURE OF MYC3 N-TERMINAL JAZ-BINDING DOMAIN [44-238] IN COMPLEX WITH JAS MOTIF OF JAZ9
Descriptor:Transcription factor MYC3, Protein TIFY 7
Authors:Ke, J., Zhang, F., Zhou, X.E., Brunzelle, J.S., Zhou, M., Xu, H.E., Melcher, K., He, S.Y.
Deposit date:2014-11-07
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
4YZ6
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CRYSTAL STRUCTURE OF MYC3[44-238] FROM ARABIDOPSIS IN COMPLEX WITH JAZ1 PEPTIDE [200-221]
Descriptor:Transcription factor MYC3, Protein TIFY 10A
Authors:Ke, J., Zhang, F., Brunzelle, J., Xu, H.E., Melcher, K., HE, S.Y.
Deposit date:2015-03-24
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
4P6W
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CRYSTAL STRUCTURE OF MOMETASONE FUROATE-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, MOMETASONE FUROATE
Authors:He, Y., Zhou, X.E., Tolbert, W.D., Powell, K., Melcher, K., Xu, H.E.
Deposit date:2014-03-25
Release date:2014-04-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Structures and mechanism for the design of highly potent glucocorticoids.
Cell Res., 24, 2014
3L3Z
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CRYSTAL STRUCTURE OF DHT-BOUND ANDROGEN RECEPTOR IN COMPLEX WITH THE THIRD MOTIF OF STEROID RECEPTOR COACTIVATOR 3
Descriptor:Androgen receptor, Nuclear receptor coactivator 3, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Zhou, X.E., Suino-Powell, K.M., Li, J., He, A., MacKeigan, J.P., Melcher, K., Yong, E.-L., Xu, H.E.
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor.
J.Biol.Chem., 285, 2010
4LEU
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CRYSTAL STRUCTURE OF THA8-LIKE PROTEIN FROM ARABIDOPSIS THALIANA
Descriptor:Pentatricopeptide repeat-containing protein At3g46870
Authors:Ke, J., Chen, R.Z., Ban, T., Brunzelle, J.S., Gu, X., Kang, Y., Melcher, K., Zhu, J.K., Xu, H.E.
Deposit date:2013-06-26
Release date:2013-09-25
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a PLS-class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition.
J.Biol.Chem., 288, 2013
5JA5
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) L111A AND L130A MUTANT IN COMPLEX WITH RICE D53 REPRESSOR EAR PEPTIDE MOTIF
Descriptor:Protein TPR1, The rice D53 peptide (a.a. 794-808), ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-12
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
5JGC
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) L111A, L130A, L179A AND I195A MUTANT
Descriptor:Protein TPR1, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-20
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
3NMP
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CRYSTAL STRUCTURE OF THE ABSCISIC RECEPTOR PYL2 MUTANT A93F IN COMPLEX WITH PYRABACTIN
Descriptor:Abscisic acid receptor PYL2, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
3NMV
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CRYSTAL STRUCTURE OF PYRABACTIN-BOUND ABSCISIC ACID RECEPTOR PYL2 MUTANT A93F IN COMPLEX WITH TYPE 2C PROTEIN PHOSPHATASE ABI2
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 77, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, ...
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
4RRU
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MYC3 N-TERMINAL JAZ-BINDING DOMAIN[5-242] FROM ARABIDOPSIS
Descriptor:Transcription factor MYC3, CALCIUM ION
Authors:Ke, J., Zhang, F., Zhou, X.E., Brunzelle, J.S., Zhou, M., Xu, H.E., Melcher, K., He, S.Y.
Deposit date:2014-11-06
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015