Author results

1DR1
  • Download 1dr1
  • View 1dr1
Molmil generated image of 1dr1
2.2 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.
Biochemistry, 31, 1992
1DR2
  • Download 1dr2
  • View 1dr2
Molmil generated image of 1dr2
2.3 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH THIONADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.
Biochemistry, 32, 1993
1DR3
  • Download 1dr3
  • View 1dr3
Molmil generated image of 1dr3
2.3 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH THIONADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.
Biochemistry, 32, 1993
1DR4
  • Download 1dr4
  • View 1dr4
Molmil generated image of 1dr4
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, MERCURY (II) ION, CALCIUM ION, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR5
  • Download 1dr5
  • View 1dr5
Molmil generated image of 1dr5
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, MERCURY (II) ION, CALCIUM ION, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR6
  • Download 1dr6
  • View 1dr6
Molmil generated image of 1dr6
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR7
  • Download 1dr7
  • View 1dr7
Molmil generated image of 1dr7
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1GTA
  • Download 1gta
  • View 1gta
Molmil generated image of 1gta
CRYSTAL STRUCTURES OF A SCHISTOSOMAL DRUG AND VACCINE TARGET: GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICA AND ITS COMPLEX WITH THE LEADING ANTISCHISTOSOMAL DRUG PRAZIQUANTEL
Descriptor:GLUTATHIONE S-TRANSFERASE
Authors:Mctigue, M.A., Tainer, J.A.
Deposit date:1994-12-01
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
J.Mol.Biol., 246, 1995
1GTB
  • Download 1gtb
  • View 1gtb
Molmil generated image of 1gtb
CRYSTAL STRUCTURES OF A SCHISTOSOMAL DRUG AND VACCINE TARGET: GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICA AND ITS COMPLEX WITH THE LEADING ANTISCHISTOSOMAL DRUG PRAZIQUANTEL
Descriptor:GLUTATHIONE S-TRANSFERASE, PRAZIQUANTEL
Authors:Mctigue, M.A., Tainer, J.A.
Deposit date:1994-12-01
Release date:1995-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
J.Mol.Biol., 246, 1995
4CLI
  • Download 4cli
  • View 4cli
Molmil generated image of 4cli
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF- 06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16, 17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE).
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-14
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CLJ
  • Download 4clj
  • View 4clj
Molmil generated image of 4clj
STRUCTURE OF L1196M MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL- 15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE).
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-14
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CMO
  • Download 4cmo
  • View 4cmo
Molmil generated image of 4cmo
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 2-((1R)-1-((3-AMINO-6-(2-METHOXYPYRIDIN-3-YL)PYRAZIN-2-YL) OXY)ETHYL)-4-FLUORO-N-METHYLBENZAMIDE
Descriptor:ALK TYROSINE KINASE RECEPTOR, 2-[(1R)-1-{[3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl]oxy}ethyl]-4-fluoro-N-methylbenzamide
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-16
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CMT
  • Download 4cmt
  • View 4cmt
Molmil generated image of 4cmt
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)ETHOXY)- 5-(3-(METHYLSULFONYL)PHENYL)PYRIDIN-2-AMINE
Descriptor:ALK TYROSINE KINASE RECEPTOR, 3-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}-5-[3-(methylsulfonyl)phenyl]pyridin-2-amine
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-17
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CMU
  • Download 4cmu
  • View 4cmu
Molmil generated image of 4cmu
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (10R)-7-AMINO-12-FLUORO-1,3,10,16-TETRAMETHYL-16,17-DIHYDRO- 1H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECIN-15(10H)-ONE
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-17
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CNH
  • Download 4cnh
  • View 4cnh
Molmil generated image of 4cnh
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2-METHOXYPHENYL)ETHOXY)-5-(1-METHYL-1H- 1,2,3-TRIAZOL-5-YL)PYRIDIN-2-AMINE
Descriptor:ALK TYROSINE KINASE RECEPTOR, 3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1H-1,2,3-triazol-5-yl)pyridin-2-amine
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-22
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CTB
  • Download 4ctb
  • View 4ctb
Molmil generated image of 4ctb
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (5R)-8-AMINO-3-FLUORO-5,19-DIMETHYL-20-OXO-5,18,19,20- TETRAHYDRO-7,11-(AZENO)PYRIDO(2',1':2,3)IMIDAZO(4,5-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-14-CARBONITRILE
Descriptor:ALK TYROSINE KINASE RECEPTOR, (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20-tetrahydro-11,7-(azeno)pyrido[2',1':2,3]imidazo[4,5-h][2,5,11]benzoxadiazacyclotetradecine-14-carbonitrile
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-03-12
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CTC
  • Download 4ctc
  • View 4ctc
Molmil generated image of 4ctc
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 7-AMINO-3-CYCLOPROPYL-12-FLUORO-1,10,16-TRIMETHYL-16,17- DIHYDRO-1H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECIN-15(10H)-ONE
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-03-12
Release date:2014-05-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
1MRP
  • Download 1mrp
  • View 1mrp
Molmil generated image of 1mrp
FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE
Descriptor:FERRIC IRON BINDING PROTEIN, FE (III) ION, PHOSPHATE ION
Authors:Bruns, C.M., Nowalk, A.J., Arvai, A.S., Mctigue, M.A., Vaughan, K.G., Mietzner, T.A., Mcree, D.E.
Deposit date:1997-05-14
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily.
Nat.Struct.Biol., 4, 1997
1VR2
  • Download 1vr2
  • View 1vr2
Molmil generated image of 1vr2
HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (KDR) KINASE DOMAIN
Descriptor:PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KINASE)
Authors:Mctigue, M., Wickersham, J., Pinko, C., Showalter, R., Parast, C., Tempczyk-Russell, A., Gehring, M., Mroczkowski, B., Kan, C., Villafranca, J., Appelt, K.
Deposit date:1998-12-03
Release date:2000-03-15
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.
Structure Fold.Des., 7, 1999
4CCB
  • Download 4ccb
  • View 4ccb
Molmil generated image of 4ccb
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 3-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)ETHOXY)-5-(5-METHYL-1H- PYRAZOL-4-YL)PYRIDIN-2-AMINE
Descriptor:ALK TYROSINE KINASE RECEPTOR, 3-[(1R)-1-[5-fluoranyl-2-(1,2,3-triazol-2-yl)phenyl]ethoxy]-5-(3-methyl-1H-pyrazol-4-yl)pyridin-2-amine
Authors:McTigue, M., Deng, Y., Liu, W., Brooun, A., Stewart, A.
Deposit date:2013-10-21
Release date:2014-01-29
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The Design of Potent and Selective Inhibitors to Overcome Clinical Alk Mutations Resistant to Crizotinib.
J.Med.Chem., 57, 2014
4CCU
  • Download 4ccu
  • View 4ccu
Molmil generated image of 4ccu
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-(5-(6-AMINO-5-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)ETHOXY) PYRIDIN-3-YL)-4-METHYLTHIAZOL-2-YL)PROPAN-2-OL
Descriptor:ALK TYROSINE KINASE RECEPTOR, 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol
Authors:McTigue, M., Deng, Y., Liu, W., Brooun, A., Stewart, A.
Deposit date:2013-10-28
Release date:2014-01-29
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Design of Potent and Selective Inhibitors to Overcome Clinical Alk Mutations Resistant to Crizotinib.
J.Med.Chem., 57, 2014
4CD0
  • Download 4cd0
  • View 4cd0
Molmil generated image of 4cd0
STRUCTURE OF L1196M MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-(5-(6-AMINO-5-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2- YL)PHENYL)ETHOXY)PYRIDIN-3-YL)-4-METHYLTHIAZOL-2-YL)PROPANE-1,2-DIOL
Descriptor:ALK TYROSINE KINASE RECEPTOR, (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol
Authors:McTigue, M., Deng, Y., Liu, W., Brooun, A., Stewart, A.
Deposit date:2013-10-29
Release date:2014-01-29
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:The Design of Potent and Selective Inhibitors to Overcome Clinical Alk Mutations Resistant to Crizotinib.
J.Med.Chem., 57, 2014
1M99
  • Download 1m99
  • View 1m99
Molmil generated image of 1m99
CRYSTAL STRUCTURE OF THE 26 KDA GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICUM COMPLEXED WITH GLUTATHIONE SULFONIC ACID
Descriptor:Glutathione S-Transferase 26kDa, GLUTATHIONE SULFONIC ACID
Authors:Cardoso, R.M.F., Daniels, D.S., Bruns, C.M., Tainer, J.A.
Deposit date:2002-07-28
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum
PROTEINS: STRUCT.,FUNCT.,GENET., 51, 2003
1M9A
  • Download 1m9a
  • View 1m9a
Molmil generated image of 1m9a
CRYSTAL STRUCTURE OF THE 26 KDA GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICUM COMPLEXED WITH S-HEXYLGLUTATHIONE
Descriptor:Glutathione S-Transferase 26 kDa, S-HEXYLGLUTATHIONE
Authors:Cardoso, R.M.F., Daniels, D.S., Bruns, C.M., Tainer, J.A.
Deposit date:2002-07-28
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum
PROTEINS: STRUCT.,FUNCT.,GENET., 51, 2003
1M9B
  • Download 1m9b
  • View 1m9b
Molmil generated image of 1m9b
CRYSTAL STRUCTURE OF THE 26 KDA GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICUM COMPLEXED WITH GAMMA-GLUTAMYL[S-(2-IODOBENZYL)CYSTEINYL]GLYCINE
Descriptor:Glutathione S-Transferase 26 kDa, GAMMA-GLUTAMYL[S-(2-IODOBENZYL)CYSTEINYL]GLYCINE
Authors:Cardoso, R.M.F., Daniels, D.S., Bruns, C.M., Tainer, J.A.
Deposit date:2002-07-28
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum
PROTEINS: STRUCT.,FUNCT.,GENET., 51, 2003