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7R7K

Structure of Human Anaplastic Lymphoma Kinase Domain in complex with (4-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]isoindolin-1-one)

Summary for 7R7K
Entry DOI10.2210/pdb7r7k/pdb
DescriptorALK tyrosine kinase receptor, 4-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1H-isoindol-1-one (3 entities in total)
Functional Keywordskinase, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight37339.79
Authors
McTigue, M. (deposition date: 2021-06-24, release date: 2022-06-29, Last modification date: 2023-10-18)
Primary citationShiba-Ishii, A.,Johnson, T.W.,Dagogo-Jack, I.,Mino-Kenudson, M.,Johnson, T.R.,Wei, P.,Weinrich, S.L.,McTigue, M.A.,Walcott, M.A.,Nguyen-Phuong, L.,Dionne, K.,Acker, A.,Kiedrowski, L.A.,Do, A.,Peterson, J.L.,Barth, J.L.,Yeap, B.Y.,Gainor, J.F.,Lin, J.J.,Yoda, S.,Hata, A.N.
Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer.
Nat Cancer, 3:710-722, 2022
Cited by
PubMed: 35726063
DOI: 10.1038/s43018-022-00399-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.831 Å)
Structure validation

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