7R7K

Structure of Human Anaplastic Lymphoma Kinase Domain in complex with (4-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]isoindolin-1-one)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ALK tyrosine kinase receptor	polymer	327	36909.4	1	UniProt (Q9UM73) Pfam (PF07714) In PDB	Homo sapiens (Human)	Anaplastic lymphoma kinase
2	A	4-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1H-isoindol-1-one	non-polymer		430.4	1	Chemie (25J)
3		water	water		18.0	259	Chemie (HOH)

Sequence modifications

A: 1093 - 1411 (UniProt: Q9UM73)

PDB	External Database	Details
Met 1085	-	expression tag
Ala 1086	-	expression tag
His 1087	-	expression tag
His 1088	-	expression tag
His 1089	-	expression tag
His 1090	-	expression tag
His 1091	-	expression tag
His 1092	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36909.4
Non-Polymers*	Number of molecules	1
	Total formula weight	430.4
All*	Total formula weight	37339.8

*Water molecules are not included.