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4CMU

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one

Summary for 4CMU
Entry DOI10.2210/pdb4cmu/pdb
Related4CLI 4CLJ 4CMO 4CMT
DescriptorALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one (3 entities in total)
Functional Keywordstransferase, receptor tyrosine kinase, inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight37304.79
Authors
McTigue, M.A.,Deng, Y.L.,Liu, W.,Brooun, A.,Stewart, A.E. (deposition date: 2014-01-17, release date: 2014-05-28, Last modification date: 2023-12-20)
Primary citationJohnson, T.W.,Richardson, P.F.,Bailey, S.,Brooun, A.,Burke, B.J.,Collins, M.R.,Cui, J.J.,Deal, J.G.,Deng, Y.L.,Dinh, D.M.,Engstrom, L.D.,He, M.,Hoffman, J.E.,Hoffman, R.L.,Huang, Q.,Kath, J.,Kania, R.S.,Lam, H.,Lam, J.L.,Le, P.T.,Lingardo, L.,Liu, W.,Mctigue, M.A.,Palmer, C.L.,Sach, N.W.,Smeal, T.,Smith, G.L.,Stewart, A.E.,Timofeevski, S.L.,Zhu, H.,Zhu, J.,Zou, H.Y.,Edwards, M.P.
Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57:4720-, 2014
Cited by
PubMed: 24819116
DOI: 10.1021/JM500261Q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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