4CMU
Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK TYROSINE KINASE RECEPTOR | polymer | 327 | 36909.4 | 1 | UniProt (Q9UM73) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | ANAPLASTIC LYMPHOMA KINASE, CD246 |
| 2 | B (A) | (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one | non-polymer | 395.4 | 1 | Chemie (IV7) | |||
| 3 | C (A) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Met 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| His 1087 | - | expression tag |
| His 1088 | - | expression tag |
| His 1089 | - | expression tag |
| His 1090 | - | expression tag |
| His 1091 | - | expression tag |
| His 1092 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36909.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 395.4 | |
| All* | Total formula weight | 37304.8 |
