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8DFR
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REFINED CRYSTAL STRUCTURES OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE. 3 ANGSTROMS APO-ENZYME AND 1.7 ANGSTROMS NADPH HOLO-ENZYME COMPLEX
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Matthews, D.A., Oatley, S.J., Burridge, J., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1989-05-30
Release date:1989-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Refined Crystal Structures of Chicken Liver Dihydrofolate Reductase. 3 Angstroms Apo-Enzyme and 1.7 Angstroms Nadph Holo-Enzyme Complex
To be Published
4DFR
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CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Filman, D.J., Matthews, D.A., Bolin, J.T., Kraut, J.
Deposit date:1982-06-25
Release date:1982-10-21
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
J.Biol.Chem., 257, 1982
3DFR
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CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE
Authors:Filman, D.J., Matthews, D.A., Bolin, J.T., Kraut, J.
Deposit date:1982-06-25
Release date:1982-10-21
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
J.Biol.Chem., 257, 1982
1HRH
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CRYSTAL STRUCTURE OF THE RIBONUCLEASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor:RIBONUCLEASE H
Authors:Davies /II, J.F., Matthews, D.A.
Deposit date:1991-03-06
Release date:1992-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase.
Science, 252, 1991
1VIE
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STRUCTURE OF DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE
Authors:Narayana, N., Matthews, D.A., Howell, E.E., Xuong, N.-H.
Deposit date:1996-10-03
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.
Nat.Struct.Biol., 2, 1995
1VIF
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STRUCTURE OF DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, FOLIC ACID
Authors:Narayana, N., Matthews, D.A., Howell, E.E., Xuong, N.-H.
Deposit date:1996-10-03
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.
Nat.Struct.Biol., 2, 1995
1DHR
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CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE
Descriptor:DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I., Skinner, M.M., Whiteley, J.M., Matthews, D.A., Xuong, N.H.
Deposit date:1992-03-30
Release date:1993-07-15
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of rat liver dihydropteridine reductase.
Proc.Natl.Acad.Sci.USA, 89, 1992
1DIR
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CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER
Descriptor:DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I., Su, Y., Skinner, M.M., Matthews, D.A., Whitely, J.M., Xuong, N.H.
Deposit date:1994-04-18
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Acta Crystallogr.,Sect.D, 50, 1994
1CQQ
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TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR
Descriptor:TYPE 2 RHINOVIRUS 3C PROTEASE, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
Authors:Matthews, D., Ferre, R.A.
Deposit date:1999-08-10
Release date:1999-09-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Proc.Natl.Acad.Sci.USA, 96, 1999
5DFR
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CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION
Authors:Bystroff, C., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30, 1991
6DFR
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CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bystroff, C., Oatley, S.J., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
Biochemistry, 29, 1990
7DFR
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CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE
Descriptor:DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bystroff, C., Oatley, S.J., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
Biochemistry, 29, 1990
1DR1
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2.2 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.
Biochemistry, 31, 1992
1DR2
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2.3 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH THIONADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.
Biochemistry, 32, 1993
1DR3
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2.3 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH THIONADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.
Biochemistry, 32, 1993
1DR4
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CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, MERCURY (II) ION, CALCIUM ION, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR5
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CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, MERCURY (II) ION, CALCIUM ION, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR6
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CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR7
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CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DHI
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LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Oatley, S.J., Villafranca, J.E., Brown, K.A., Kraut, J.
Deposit date:1993-10-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1DHJ
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LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Brown, K.A., Kraut, J.
Deposit date:1993-10-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1DRA
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CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Oatley, S.J., Kraut, J.
Deposit date:1991-11-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30, 1991
1DRB
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CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:David, C., Kraut, J.
Deposit date:1991-11-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30, 1991
1DYH
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ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, 5-DEAZAFOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DYI
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ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, FOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
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