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7Q8V
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BU of 7q8v by Molmil
Crystal structure of TTBK1 in complex with VNG2.73 (compound 42)
Descriptor: PHOSPHATE ION, Tau-tubulin kinase 1, ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
7Q8Y
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BU of 7q8y by Molmil
Crystal structure of TTBK2 in complex with VNG2.73 (compound 42)
Descriptor: PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
7Q8Z
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BU of 7q8z by Molmil
Crystal structure of TTBK2 in complex with VNG1.33 (compound 27)
Descriptor: PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-(4-phenoxyphenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
7Q8W
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BU of 7q8w by Molmil
Crystal structure of TTBK1 in complex with VNG1.35 (compound 23)
Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Tau-tubulin kinase 1, ...
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
7Q90
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BU of 7q90 by Molmil
Crystal structure of TTBK2 in complex with VNG1.63 (compound 32)
Descriptor: PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-[4-(4-methoxyphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
6XF9
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BU of 6xf9 by Molmil
Crystal structure of KSHV ORF68
Descriptor: Packaging protein UL32, ZINC ION
Authors:Didychuk, A.L, Gates, S.N, Martin, A, Glaunsinger, B.
Deposit date:2020-06-15
Release date:2021-02-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A pentameric protein ring with novel architecture is required for herpesviral packaging.
Elife, 10, 2021
6XFA
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BU of 6xfa by Molmil
Cryo-EM structure of EBV BFLF1
Descriptor: Packaging protein UL32, ZINC ION
Authors:Didychuk, A.L, Gates, S.N, Martin, A, Glaunsinger, B.
Deposit date:2020-06-15
Release date:2021-02-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A pentameric protein ring with novel architecture is required for herpesviral packaging.
Elife, 10, 2021
2Y2G
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BU of 2y2g by Molmil
PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (A01)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1B, ...
Authors:Contreras-Martel, C, Amoroso, A, Woon, E.C, Zervosen, A, Inglis, S, Martins, A, Verlaine, O, Rydzik, A, Job, V, Luxen, A, Joris, B, Schofield, C.J, Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
2Y2N
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BU of 2y2n by Molmil
PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E07)
Descriptor: CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1B, SODIUM ION, ...
Authors:Contreras-Martel, C, Amoroso, A, Woon, E.C, Zervosen, A, Inglis, S, Martins, A, Verlaine, O, Rydzik, A, Job, V, Luxen, A, Joris, B, Schofield, C.J, Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
2Y2Q
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BU of 2y2q by Molmil
PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (Z06)
Descriptor: (3-acetamido-5-carboxy-phenyl)-trihydroxy-boron, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Contreras-Martel, C, Amoroso, A, Woon, E.C, Zervosen, A, Inglis, S, Martins, A, Verlaine, O, Rydzik, A, Job, V, Luxen, A, Joris, B, Schofield, C.J, Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
7Q48
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BU of 7q48 by Molmil
Solution structure of an intramolecular RNA G-quadruplex formed by the 6A8U17U mutant from a 22mer guanine-rich sequence within the 5'UTR of BCL-2 proto onco-gene
Descriptor: RNA (5'-R(*GP*GP*GP*CP*CP*AP*UP*UP*GP*GP*GP*UP*GP*GP*GP*AP*UP*CP*UP*GP*GP*G)-3')
Authors:Wang, Z, Jurt, S, Dominguez-Martin, A, Johannsen, S, Sigel, R.K.O.
Deposit date:2021-10-29
Release date:2022-11-16
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Solution structure of an intramolecular RNA G-quadruplex formed by the 6A8U17U mutant from a 22mer guanine-rich sequence within the 5'UTR of BCL-2 proto onco-gene
To Be Published
7Q6L
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BU of 7q6l by Molmil
Solution structure of an intramolecular RNA G-quadruplex formed by the 6A8A17U mutant from a 22mer guanine-rich sequence within the 5'UTR of BCL-2 proto-oncogene
Descriptor: RNA (5'-R(*GP*GP*GP*CP*CP*AP*UP*AP*GP*GP*GP*UP*GP*GP*GP*AP*UP*CP*UP*GP*GP*G)-3')
Authors:Wang, Z, Jurt, S, Dominguez-Martin, A, Johannsen, S, Sigel, R.K.O.
Deposit date:2021-11-08
Release date:2022-11-16
Last modified:2024-01-31
Method:SOLUTION NMR
Cite:Solution structure of an intramolecular RNA G-quadruplex formed by the 6A8A17U mutant from a 22mer guanine-rich sequence within the 5'UTR of BCL-2 proto-oncogene
To Be Published
3J47
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BU of 3j47 by Molmil
Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid
Descriptor: 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit RPN3, ...
Authors:Estrin, E, Lopez-Blanco, J.R, Chacon, P, Martin, A.
Deposit date:2013-06-27
Release date:2013-08-28
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Formation of an Intricate Helical Bundle Dictates the Assembly of the 26S Proteasome Lid.
Structure, 21, 2013
6EF0
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BU of 6ef0 by Molmil
Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state)
Descriptor: 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ...
Authors:de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A.
Deposit date:2018-08-15
Release date:2018-10-17
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.43 Å)
Cite:Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
6EF1
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BU of 6ef1 by Molmil
Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)
Descriptor: 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ...
Authors:de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A.
Deposit date:2018-08-15
Release date:2018-10-17
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.73 Å)
Cite:Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
6EF2
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BU of 6ef2 by Molmil
Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state)
Descriptor: 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ...
Authors:de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A.
Deposit date:2018-08-15
Release date:2018-10-17
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.27 Å)
Cite:Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
6EF3
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BU of 6ef3 by Molmil
Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)
Descriptor: 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ...
Authors:de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A.
Deposit date:2018-08-15
Release date:2018-10-17
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
5U4P
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BU of 5u4p by Molmil
Protein-protein complex between 26S proteasome regulatory subunit RPN8, RPN11, and Ubiquitin S31
Descriptor: 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8, Ubiquitin-40S ribosomal protein S31, ...
Authors:Worden, E.J, Dong, K.C, Martin, A.
Deposit date:2016-12-05
Release date:2017-09-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
Mol. Cell, 67, 2017
5W83
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BU of 5w83 by Molmil
Rpn8/Rpn11 dimer complex
Descriptor: 26S proteasome regulatory subunit RPN8, Ubiquitin carboxyl-terminal hydrolase RPN11, ZINC ION
Authors:Dong, K.C, Worden, E.J, Martin, A.
Deposit date:2017-06-21
Release date:2017-09-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
Mol. Cell, 67, 2017
1HZF
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BU of 1hzf by Molmil
C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A
Descriptor: COMPLEMENT FACTOR C4A
Authors:van den Elsen, J.M.H, Martin, A, Wong, V, Clemenza, L, Rose, D.R, Isenman, D.E.
Deposit date:2001-01-24
Release date:2002-10-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray crystal structure of the C4d fragment of human complement component C4.
J.Mol.Biol., 322, 2002
3HWS
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BU of 3hws by Molmil
Crystal structure of nucleotide-bound hexameric ClpX
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit clpX, MAGNESIUM ION, ...
Authors:Glynn, S.E, Martin, A, Baker, T.A, Sauer, R.T.
Deposit date:2009-06-18
Release date:2009-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Cell(Cambridge,Mass.), 139, 2009
3JCK
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BU of 3jck by Molmil
Structure of the yeast 26S proteasome lid sub-complex
Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit RPN3, ...
Authors:Herzik Jr, M.A, Dambacher, C.M, Worden, E.J, Martin, A, Lander, G.C.
Deposit date:2015-12-20
Release date:2016-01-20
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.
Elife, 5, 2016
3HTE
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BU of 3hte by Molmil
Crystal structure of nucleotide-free hexameric ClpX
Descriptor: ATP-dependent Clp protease ATP-binding subunit clpX, SULFATE ION
Authors:Glynn, S.E, Martin, A, Baker, T.A, Sauer, R.T.
Deposit date:2009-06-11
Release date:2009-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (4.026 Å)
Cite:Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Cell(Cambridge,Mass.), 139, 2009
6I2V
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BU of 6i2v by Molmil
Pilotin from Vibrio vulnificus type 2 secretion system, EpsS.
Descriptor: 1,2-ETHANEDIOL, PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Howard, S.P, Estrozi, L, Bertrand, Q, Contreras-Martel, C, Strozen, T, Job, V, Martins, A, Fenel, D, Schoehn, G, Dessen, A.
Deposit date:2018-11-02
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system.
Plos Pathog., 15, 2019
2LZP
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BU of 2lzp by Molmil
Structure of NS2(2-32) GBVB protein
Descriptor: NS2 peptide
Authors:Montserret, R, Penin, F, Martin, A.
Deposit date:2012-10-08
Release date:2014-04-09
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies.
J.Virol., 88, 2014

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