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2WVS
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CRYSTAL STRUCTURE OF AN ALPHA-L-FUCOSIDASE GH29 TRAPPED COVALENT INTERMEDIATE FROM BACTEROIDES THETAIOTAOMICRON IN COMPLEX WITH 2- FLUORO-FUCOSYL FLUORIDE USING AN E288Q MUTANT
Descriptor:ALPHA-L-FUCOSIDASE, 2-DEOXY-2-FLUORO-BETA-L-FUCOPYRANOSE, SULFATE ION
Authors:Lammerts van Bueren, A., Ardevol, A., Fayers-Kerr, J., Luo, B., Zhang, Y., Sollogoub, M., Bleriot, Y., Rovira, C., Davies, G.J.
Deposit date:2009-10-20
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Analysis of the Reaction Coordinate of Alpha-L-Fucosidases: A Combined Structural and Quantum Mechanical Approach
J.Am.Chem.Soc., 132, 2010
2WVT
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CRYSTAL STRUCTURE OF AN ALPHA-L-FUCOSIDASE GH29 FROM BACTEROIDES THETAIOTAOMICRON IN COMPLEX WITH A NOVEL IMINOSUGAR FUCOSIDASE INHIBITOR
Descriptor:ALPHA-L-FUCOSIDASE, (2S,3R,5R,6S)-3,4,5-TRIHYDROXY-2,6-BIS(HYDROXYMETHYL)PIPERIDINIUM, GLYCEROL, ...
Authors:Lammerts van Bueren, A., Ardevol, A., Fayers-Kerr, J., Luo, B., Zhang, Y., Sollogoub, M., Bleriot, Y., Rovira, C., Davies, G.J.
Deposit date:2009-10-20
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Analysis of the Reaction Coordinate of Alpha-L-Fucosidases: A Combined Structural and Quantum Mechanical Approach.
J.Am.Chem.Soc., 132, 2010
2WVU
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CRYSTAL STRUCTURE OF A MICHAELIS COMPLEX OF ALPHA-L-FUCOSIDASE GH29 FROM BACTEROIDES THETAIOTAOMICRON WITH THE SYNTHETIC SUBSTRATE 4- NITROPHENYL-ALPHA-L-FUCOSE
Descriptor:ALPHA-L-FUCOSIDASE, SULFATE ION, 4-nitrophenyl-alpha-L-fucose
Authors:Lammerts van Bueren, A., Ardevol, A., Fayers-Kerr, J., Luo, B., Zhang, Y., Sollogoub, M., Bleriot, Y., Rovira, C., Davies, G.J.
Deposit date:2009-10-20
Release date:2010-02-02
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Analysis of the Reaction Coordinate of Alpha-L-Fucosidases: A Combined Structural and Quantum Mechanical Approach
J.Am.Chem.Soc., 132, 2010
2WVV
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CRYSTAL STRUCTURE OF AN ALPHA-L-FUCOSIDASE GH29 FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:ALPHA-L-FUCOSIDASE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, ...
Authors:Lammerts van Bueren, A., Ardevol, A., Fayers-Kerr, J., Luo, B., Zhang, Y., Sollogoub, M., Bleriot, Y., Rovira, C., Davies, G.J.
Deposit date:2009-10-20
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Analysis of the Reaction Coordinate of Alpha-L-Fucosidases: A Combined Structural and Quantum Mechanical Approach
J.Am.Chem.Soc., 132, 2010
4G1E
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CRYSTAL STRUCTURE OF INTEGRIN ALPHA V BETA 3 WITH COIL-COILED TAG.
Descriptor:Integrin alpha-V, Integrin beta-3, CALCIUM ION, ...
Authors:Dong, X., Mi, L., Zhu, J., Wang, W., Luo, B., Springer, T.A.
Deposit date:2012-07-10
Release date:2012-12-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:AlphaV Beta3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
4RWI
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CRYSTAL STRUCTURE OF V561M FGFR1 GATEKEEPER MUTATION (C488A, C584S, V561M), APO
Descriptor:Fibroblast growth factor receptor 1
Authors:Sohl, C.D., Anderson, K.S.
Deposit date:2014-12-04
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy.
Acs Chem.Biol., 10, 2015
4RWJ
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CRYSTAL STRUCTURE OF FGFR1 (C488A, C584S) IN COMPLEX WITH AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)
Descriptor:Fibroblast growth factor receptor 1, N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide
Authors:Sohl, C.D., Anderson, K.S.
Deposit date:2014-12-04
Release date:2015-04-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy.
Acs Chem.Biol., 10, 2015
4RWK
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CRYSTAL STRUCTURE OF V561M FGFR1 GATEKEEPER MUTATION (C488A, C584S, V561M) IN COMPLEX WITH N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE (AZD4547)
Descriptor:Fibroblast growth factor receptor 1, N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide, MAGNESIUM ION
Authors:Sohl, C.D., Anderson, K.S.
Deposit date:2014-12-04
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.982 Å)
Cite:Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy.
Acs Chem.Biol., 10, 2015
4RWL
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CRYSTAL STRUCTURE OF FGFR1 (C488A, C584C) IN COMPLEX WITH 6-(7-((1-AMINOCYCLOPROPYL) METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE (E3810)
Descriptor:Fibroblast growth factor receptor 1, 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-N-methylnaphthalene-1-carboxamide, SULFATE ION
Authors:Sohl, C.D., Anderson, K.S.
Deposit date:2014-12-04
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.193 Å)
Cite:Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy.
Acs Chem.Biol., 10, 2015