8T9Z

Structural of M8C10 Fab in complex human metapneumovirus fusion protein

Summary for 8T9Z

• Entry DOI: 10.2210/pdb8t9z/pdb
• Descriptor: Fusion glycoprotein F0, M8C10 Fab Heavy Chain, M8C10 Fab Light Chain, ... (4 entities in total)
• Functional Keywords: neutralizing antibody, respiratory, metapneumovirus, fusion, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human metapneumovirus; More
• Total number of polymer chains: 3
• Total formula weight: 100125.63

Authors

Su, H.P.,Eddins, M.J.,Shipman, J.M.,Kostas, J.,Reid, J.C. (deposition date: 2023-06-26, release date: 2023-11-22, Last modification date: 2024-11-20)

Primary citation

Xiao, X.,Wen, Z.,Chen, Q.,Shipman, J.M.,Kostas, J.,Reid, J.C.,Warren, C.,Tang, A.,Luo, B.,O'Donnell, G.,Fridman, A.,Chen, Z.,Vora, K.A.,Zhang, L.,Su, H.-P.,Eddins, M.J.
Structural characterization of M8C10, a neutralizing antibody targeting a highly conserved prefusion-specific epitope on the metapneumovirus fusion trimerization interface.
J.Virol., 97:e0105223-e0105223, 2023

PubMed Abstract: Human metapneumovirus (hMPV) is a common pathogen causing lower respiratory tract infections worldwide and can develop severe symptoms in high-risk populations such as infants, the elderly, and immunocompromised patients. There are no approved hMPV vaccines or neutralizing antibodies available for therapeutic or prophylactic use. The trimeric hMPV fusion F protein is the major target of neutralizing antibodies in human sera. Understanding the immune recognition of antibodies to hMPV-F antigen will provide critical insights into developing efficacious hMPV monoclonal antibodies and vaccines.

PubMed: 38032197
DOI: 10.1128/jvi.01052-23

Experimental method

X-RAY DIFFRACTION (2.995 Å)