Author results

1RK4
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CRYSTAL STRUCTURE OF A SOLUBLE DIMERIC FORM OF OXIDISED CLIC1
Descriptor:CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Littler, D.R., Harrop, S.J., Fairlie, W.D., Brown, L.J., Pankhurst, G.J., Pankhurst, S., DeMaere, M.Z., Campbell, T.J., Bauskin, A.R., Tonini, R., Mazzanti, M., Breit, S.N., Curmi, P.M.
Deposit date:2003-11-20
Release date:2003-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition
J.Biol.Chem., 279, 2004
2AHE
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CRYSTAL STRUCTURE OF A SOLUBLE FORM OF CLIC4. INTERCELLULAR CHLORIDE ION CHANNEL
Descriptor:Chloride intracellular channel protein 4
Authors:Littler, D.R., Assaad, N.N., Harrop, S.J., Brown, L.J., Pankhurst, G.J., Luciani, P., Aguilar, M.-I., Mazzanti, M., Berryman, M.A., Breit, S.N., Curmi, P.M.G.
Deposit date:2005-07-28
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4.
FEBS J., 272, 2005
2H6D
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PROTEIN KINASE DOMAIN OF THE HUMAN 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (AMPK ALPHA-2 CHAIN)
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-2
Authors:Littler, D.R., Walker, J.R., Wybenga-Groot, L., Newman, E.M., Butler-Cole, C., Mackenzie, F., Finerty, P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-05-31
Release date:2006-06-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66, 2010
3FY7
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CRYSTAL STRUCTURE OF HOMO SAPIENS CLIC3
Descriptor:Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R., Curmi, P.M.G., Breit, S.N., Perrakis, A.
Deposit date:2009-01-22
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
3G73
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STRUCTURE OF THE FOXM1 DNA BINDING
Descriptor:Forkhead box protein M1, DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), ...
Authors:Littler, D.R., Perrakis, A., Hibbert, R.G., Medema, R.H.
Deposit date:2009-02-09
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
3KJY
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CRYSTAL STRUCTURE OF REDUCED HOMO SAPIENS CLIC3
Descriptor:Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R., Curmi, P.M.G., Breit, S.N., Perrakis, A.
Deposit date:2009-11-04
Release date:2009-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
4Z9C
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ECPLTAB OXIDIZED
Descriptor:Pertussis toxin-like subunit ArtA, Subtilase cytotoxin subunit B-like protein, PHOSPHATE ION
Authors:Littler, D.R., Johnson, M.D., Summers, R.J., Schembri, M.A., Rossjohn, J., Beddoe, T.
Deposit date:2015-04-10
Release date:2016-10-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
4Z9D
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ECPLTA
Descriptor:Pertussis toxin-like subunit ArtA, SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Littler, D.R., Johnson, M.D., Summers, R.J., Schembri, M.A., Rossjohn, J., Beddoe, T.
Deposit date:2015-04-10
Release date:2016-10-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
5K8S
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CAMP BOUND PFPKA-R (297-441)
Descriptor:CAMP-dependent protein kinase regulatory subunit, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Authors:Littler, D.R., Gilson, P.R., Crabb, B.S., Rossjohn, J.J.
Deposit date:2016-05-31
Release date:2016-10-12
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
5KBF
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CAMP BOUND PFPKA-R (141-441)
Descriptor:CAMP-dependent protein kinase regulatory subunit, putative, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Authors:Littler, D.R., Gilson, P.R., Crabb, B.S., Rossjohn, J.J.
Deposit date:2016-06-03
Release date:2016-10-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
5T3N
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SP-2CL-CAMPS BOUND TO PKAR CBD2
Descriptor:cAMP-dependent protein kinase regulatory subunit, IODIDE ION, (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
Authors:Littler, D.R., Gilson, P.
Deposit date:2016-08-26
Release date:2016-10-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
2FK9
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HUMAN PROTEIN KINASE C, ETA
Descriptor:protein kinase C, eta type
Authors:Walker, J.R., Littler, D.R., Finerty Jr., P.J., MacKenzie, F., Newman, E.M., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-01-04
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
Biochem.Biophys.Res.Commun., 349, 2006
2YV7
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CRYSTAL STRUCTURE OF THE CLIC HOMOLOG FROM DROSOPHILA MELANOGASTER
Descriptor:CG10997-PA, CALCIUM ION, IODIDE ION
Authors:Harrop, S.J., Littler, D.R., Curmi, P.M.G.
Deposit date:2007-04-10
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC
Proteins, 71, 2007
2YV9
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CRYSTAL STRUCTURE OF THE CLIC HOMOLOGUE EXC-4 FROM C. ELEGANS
Descriptor:Chloride intracellular channel exc-4, CALCIUM ION
Authors:Harrop, S.J., Littler, D.R., Curmi, P.M.G.
Deposit date:2007-04-10
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC
Proteins, 71, 2007
4L63
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APO FORM OF AB5 HOLOTOXIN
Descriptor:ECXA, ECXB, ZINC ION, ...
Authors:Littler, D.R., Ng, N.M., Rossjohn, J., Beddoe, T.
Deposit date:2013-06-11
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
4L6T
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GM1 BOUND FORM OF THE ECX AB5 HOLOTOXIN
Descriptor:ECXA, ECXB, ZINC ION, ...
Authors:Littler, D.R., Ng, N.M., Rossjohn, J., Beddoe, T.
Deposit date:2013-06-12
Release date:2013-11-06
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
3BFO
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CRYSTAL STRUCTURE OF IG-LIKE C2-TYPE 2 DOMAIN OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1
Descriptor:Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Isoform 2)
Authors:Walker, J.R., Akutsu, M., Littler, D.R., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-11-22
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of the Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1.
To be Published
4P15
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STRUCTURE OF THE CLPC N-TERMINAL DOMAIN FROM AN ALKALIPHILIC BACILLUS LEHENSIS G1 SPECIES
Descriptor:Bacillus lehensis ClpC N-terminal domain, SULFATE ION
Authors:Rashid, S.A., Littler, D.R., Illias, R.M., Murad, A.M.A., Rossjohn, J., Beddoe, T., Mahadi, N.M.
Deposit date:2014-01-31
Release date:2014-07-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the ClpC N-terminal domain at 1.85 Angstroms resolution from an alkaliphilic Bacillus lehensis G1 species
To Be Published
2R4V
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STRUCTURE OF HUMAN CLIC2, CRYSTAL FORM A
Descriptor:Chloride intracellular channel protein 2, GLUTATHIONE
Authors:Hansen, G., Cromer, B.A., Gorman, M.A., Parker, M.W.
Deposit date:2007-09-02
Release date:2007-11-13
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
2R5G
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STRUCTURE OF HUMAN CLIC2, CRYSTAL FORM B
Descriptor:Chloride intracellular channel protein 2
Authors:Gorman, M.A., Hansen, G., Cromer, B.A., Parker, M.W.
Deposit date:2007-09-03
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
4PN6
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STRUCTURE OF THE CYTOMEGALOVIRUS-ENCODED M04 GLYCOPROTEIN
Descriptor:M04, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Berry, R., Rossjohn, J.
Deposit date:2014-05-23
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins.
J.Biol.Chem., 289, 2014