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5KBF
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BU of 5kbf by Molmil
cAMP bound PfPKA-R (141-441)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit, putative
Authors:Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J.
Deposit date:2016-06-03
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
2AHE
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BU of 2ahe by Molmil
Crystal structure of a soluble form of CLIC4. intercellular chloride ion channel
Descriptor: Chloride intracellular channel protein 4
Authors:Littler, D.R, Assaad, N.N, Harrop, S.J, Brown, L.J, Pankhurst, G.J, Luciani, P, Aguilar, M.-I, Mazzanti, M, Berryman, M.A, Breit, S.N, Curmi, P.M.G.
Deposit date:2005-07-28
Release date:2005-08-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4.
FEBS J., 272, 2005
6WXD
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BU of 6wxd by Molmil
SARS-CoV-2 Nsp9 RNA-replicase
Descriptor: Non-structural protein 9, SULFATE ION
Authors:Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J.
Deposit date:2020-05-10
Release date:2020-05-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
5K8S
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BU of 5k8s by Molmil
cAMP bound PfPKA-R (297-441)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit
Authors:Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J.
Deposit date:2016-05-31
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
1RK4
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BU of 1rk4 by Molmil
Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1
Descriptor: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Littler, D.R, Harrop, S.J, Fairlie, W.D, Brown, L.J, Pankhurst, G.J, Pankhurst, S, DeMaere, M.Z, Campbell, T.J, Bauskin, A.R, Tonini, R, Mazzanti, M, Breit, S.N, Curmi, P.M.
Deposit date:2003-11-20
Release date:2003-12-02
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition
J.Biol.Chem., 279, 2004
3FY7
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BU of 3fy7 by Molmil
Crystal structure of homo sapiens CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-01-22
Release date:2009-02-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
3G73
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BU of 3g73 by Molmil
Structure of the FOXM1 DNA binding
Descriptor: DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ...
Authors:Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H.
Deposit date:2009-02-09
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
4Z9C
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BU of 4z9c by Molmil
EcPltAB Oxidized
Descriptor: PHOSPHATE ION, Pertussis toxin-like subunit ArtA, Subtilase cytotoxin subunit B-like protein
Authors:Littler, D.R, Johnson, M.D, Summers, R.J, Schembri, M.A, Rossjohn, J, Beddoe, T.
Deposit date:2015-04-10
Release date:2016-10-12
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
4Z9D
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BU of 4z9d by Molmil
EcPltA
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pertussis toxin-like subunit ArtA, SODIUM ION
Authors:Littler, D.R, Johnson, M.D, Summers, R.J, Schembri, M.A, Rossjohn, J, Beddoe, T.
Deposit date:2015-04-10
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
6W9Q
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BU of 6w9q by Molmil
Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase
Descriptor: 3C-like proteinase peptide, Non-structural protein 9 fusion, PHOSPHATE ION
Authors:Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J.
Deposit date:2020-03-23
Release date:2020-04-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
6WC1
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BU of 6wc1 by Molmil
Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase
Descriptor: SARS-coV-2 Non-structural protein 9, SULFATE ION
Authors:Littler, D.R, Gully, B.S, Rossjohn, J.
Deposit date:2020-03-28
Release date:2020-08-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of a putative peptide-binding site at the dimer interface of the SARS-CoV-2 Nsp9 RNA-replicase.
To Be Published
2H6D
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BU of 2h6d by Molmil
Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain)
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-2
Authors:Littler, D.R, Walker, J.R, Wybenga-Groot, L, Newman, E.M, Butler-Cole, C, Mackenzie, F, Finerty, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2006-05-31
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66, 2010
5T3N
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BU of 5t3n by Molmil
Sp-2Cl-cAMPS bound to PKAR CBD2
Descriptor: (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, IODIDE ION, cAMP-dependent protein kinase regulatory subunit
Authors:Littler, D.R, Gilson, P.
Deposit date:2016-08-26
Release date:2016-10-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
3KJY
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BU of 3kjy by Molmil
Crystal structure of reduced HOMO SAPIENS CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-11-04
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
7KRI
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BU of 7kri by Molmil
FR6-bound SARS-CoV-2 Nsp9 RNA-replicase
Descriptor: 1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, MALONATE ION, Non-structural protein 9, ...
Authors:Littler, D.R, Gully, B.S, Rossjohn, J.
Deposit date:2020-11-20
Release date:2021-07-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9.
J.Biol.Chem., 297, 2021
7N3K
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BU of 7n3k by Molmil
Oridonin-bound SARS-CoV-2 Nsp9
Descriptor: (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, Non-structural protein 9, SULFATE ION
Authors:Littler, D.R, Gully, B.S, Rossjohn, J.
Deposit date:2021-06-01
Release date:2021-10-27
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein.
J.Biol.Chem., 297, 2021
2FK9
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BU of 2fk9 by Molmil
Human protein kinase C, eta
Descriptor: protein kinase C, eta type
Authors:Walker, J.R, Littler, D.R, Finerty Jr, P.J, MacKenzie, F, Newman, E.M, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2006-01-04
Release date:2006-01-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
Biochem.Biophys.Res.Commun., 349, 2006
2YV9
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BU of 2yv9 by Molmil
Crystal structure of the CLIC homologue EXC-4 from c. elegans
Descriptor: CALCIUM ION, Chloride intracellular channel exc-4
Authors:Harrop, S.J, Littler, D.R, Curmi, P.M.G.
Deposit date:2007-04-10
Release date:2008-02-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC
Proteins, 71, 2007
2YV7
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BU of 2yv7 by Molmil
Crystal structure of the CLIC homolog from drosophila melanogaster
Descriptor: CALCIUM ION, CG10997-PA, IODIDE ION
Authors:Harrop, S.J, Littler, D.R, Curmi, P.M.G.
Deposit date:2007-04-10
Release date:2008-02-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC
Proteins, 71, 2007
8DQU
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BU of 8dqu by Molmil
Nanobody bound SARS-CoV-2 Nsp9
Descriptor: Nanobody, Non-structural protein 9
Authors:Littler, D.R, Gully, B.S, Rossjohn, J.
Deposit date:2022-07-20
Release date:2023-02-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.45003176 Å)
Cite:Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9.
Plos One, 18, 2023
8SHI
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BU of 8shi by Molmil
Valpha3S1 Vbeta13S1 HLA C 0602 VRSRRCLRL
Descriptor: Beta-2-microglobulin, MHC class I antigen (Fragment), T cell receptor alpha, ...
Authors:Littler, D.R, Anand, S, Vivian, J.P, Rossjohn, J.
Deposit date:2023-04-14
Release date:2023-06-28
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.90001726 Å)
Cite:Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02.
J.Biol.Chem., 299, 2023
8TUB
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BU of 8tub by Molmil
HLA B7:02 with HPNGYKSLSTL
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
Authors:Littler, D.R, Rossjohn, J, Chaurasia, P, Petersen, J.
Deposit date:2023-08-16
Release date:2024-03-13
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
Nat Commun, 15, 2024
8TUH
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BU of 8tuh by Molmil
HLA B7:02 with RPIIRPATL
Descriptor: 1,2-ETHANEDIOL, ARG-PRO-ILE-ILE-ARG-PRO-ALA-THR-LEU, Beta-2-microglobulin, ...
Authors:Littler, D.R, Rossjohn, J, Chaurasia, P, Petersen, J.
Deposit date:2023-08-16
Release date:2024-03-13
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.200106 Å)
Cite:CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
Nat Commun, 15, 2024
8V4Z
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BU of 8v4z by Molmil
Crystal structure of a HLA-B*35:01-NP7 with D1 TCR
Descriptor: Beta-2-microglobulin, D1 TCR alpha chain, D1 TCR beta chain, ...
Authors:Littler, D.R, Rossjohn, J.
Deposit date:2023-11-29
Release date:2024-12-18
Last modified:2025-02-26
Method:X-RAY DIFFRACTION (2.400002 Å)
Cite:Molecular determinants of cross-strain influenza A virus recognition by alpha beta T cell receptors.
Sci Immunol, 10, 2025
8V50
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BU of 8v50 by Molmil
Crystal structure of a HLA-B*35:01-NP6 with D1 TCR
Descriptor: Beta-2-microglobulin, D1 TCR alpha chain, D1 TCR beta chain, ...
Authors:Littler, D.R, Rossjohn, J, Gras, S.
Deposit date:2023-11-30
Release date:2024-12-18
Last modified:2025-02-26
Method:X-RAY DIFFRACTION (2.65001774 Å)
Cite:Molecular determinants of cross-strain influenza A virus recognition by alpha beta T cell receptors.
Sci Immunol, 10, 2025

 

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