1RK4 | | CRYSTAL STRUCTURE OF A SOLUBLE DIMERIC FORM OF OXIDISED CLIC1 | | Descriptor: | CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1 | | Authors: | Littler, D.R., Harrop, S.J., Fairlie, W.D., Brown, L.J., Pankhurst, G.J., Pankhurst, S., DeMaere, M.Z., Campbell, T.J., Bauskin, A.R., Tonini, R., Mazzanti, M., Breit, S.N., Curmi, P.M. | | Deposit date: | 2003-11-20 | | Release date: | 2003-12-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.792 Å) | | Cite: | The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition
J.Biol.Chem., 279, 2004
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2AHE | | CRYSTAL STRUCTURE OF A SOLUBLE FORM OF CLIC4. INTERCELLULAR CHLORIDE ION CHANNEL | | Descriptor: | Chloride intracellular channel protein 4 | | Authors: | Littler, D.R., Assaad, N.N., Harrop, S.J., Brown, L.J., Pankhurst, G.J., Luciani, P., Aguilar, M.-I., Mazzanti, M., Berryman, M.A., Breit, S.N., Curmi, P.M.G. | | Deposit date: | 2005-07-28 | | Release date: | 2005-08-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4.
FEBS J., 272, 2005
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2H6D | | PROTEIN KINASE DOMAIN OF THE HUMAN 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (AMPK ALPHA-2 CHAIN) | | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | | Authors: | Littler, D.R., Walker, J.R., Wybenga-Groot, L., Newman, E.M., Butler-Cole, C., Mackenzie, F., Finerty, P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-05-31 | | Release date: | 2006-06-27 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66, 2010
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3FY7 | | CRYSTAL STRUCTURE OF HOMO SAPIENS CLIC3 | | Descriptor: | Chloride intracellular channel protein 3, SULFATE ION | | Authors: | Littler, D.R., Curmi, P.M.G., Breit, S.N., Perrakis, A. | | Deposit date: | 2009-01-22 | | Release date: | 2009-02-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
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3G73 | | STRUCTURE OF THE FOXM1 DNA BINDING | | Descriptor: | Forkhead box protein M1, DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), ... | | Authors: | Littler, D.R., Perrakis, A., Hibbert, R.G., Medema, R.H. | | Deposit date: | 2009-02-09 | | Release date: | 2009-03-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
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3KJY | | CRYSTAL STRUCTURE OF REDUCED HOMO SAPIENS CLIC3 | | Descriptor: | Chloride intracellular channel protein 3, SULFATE ION | | Authors: | Littler, D.R., Curmi, P.M.G., Breit, S.N., Perrakis, A. | | Deposit date: | 2009-11-04 | | Release date: | 2009-11-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
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4Z9C | | ECPLTAB OXIDIZED | | Descriptor: | Pertussis toxin-like subunit ArtA, Subtilase cytotoxin subunit B-like protein, PHOSPHATE ION | | Authors: | Littler, D.R., Johnson, M.D., Summers, R.J., Schembri, M.A., Rossjohn, J., Beddoe, T. | | Deposit date: | 2015-04-10 | | Release date: | 2016-10-12 | | Last modified: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
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4Z9D | | ECPLTA | | Descriptor: | Pertussis toxin-like subunit ArtA, SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Littler, D.R., Johnson, M.D., Summers, R.J., Schembri, M.A., Rossjohn, J., Beddoe, T. | | Deposit date: | 2015-04-10 | | Release date: | 2016-10-12 | | Last modified: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
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5K8S | | CAMP BOUND PFPKA-R (297-441) | | Descriptor: | CAMP-dependent protein kinase regulatory subunit, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | Authors: | Littler, D.R., Gilson, P.R., Crabb, B.S., Rossjohn, J.J. | | Deposit date: | 2016-05-31 | | Release date: | 2016-10-12 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
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5KBF | | CAMP BOUND PFPKA-R (141-441) | | Descriptor: | CAMP-dependent protein kinase regulatory subunit, putative, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | Authors: | Littler, D.R., Gilson, P.R., Crabb, B.S., Rossjohn, J.J. | | Deposit date: | 2016-06-03 | | Release date: | 2016-10-12 | | Last modified: | 2020-01-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
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5T3N | | SP-2CL-CAMPS BOUND TO PKAR CBD2 | | Descriptor: | cAMP-dependent protein kinase regulatory subunit, IODIDE ION, (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | | Authors: | Littler, D.R., Gilson, P. | | Deposit date: | 2016-08-26 | | Release date: | 2016-10-12 | | Last modified: | 2020-01-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
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6W9Q | | PEPTIDE-BOUND SARS-COV-2 NSP9 RNA-REPLICASE | | Descriptor: | 3C-like proteinase peptide, Non-structural protein 9 fusion, PHOSPHATE ION | | Authors: | Littler, D.R., Gully, B.S., Riboldi-Tunnicliffe, A., Rossjohn, J. | | Deposit date: | 2020-03-23 | | Release date: | 2020-04-08 | | Last modified: | 2020-09-09 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
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6WC1 | |
6WXD | | SARS-COV-2 NSP9 RNA-REPLICASE | | Descriptor: | Non-structural protein 9, SULFATE ION | | Authors: | Littler, D.R., Gully, B.S., Riboldi-Tunnicliffe, A., Rossjohn, J. | | Deposit date: | 2020-05-10 | | Release date: | 2020-05-20 | | Last modified: | 2020-09-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
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2FK9 | | HUMAN PROTEIN KINASE C, ETA | | Descriptor: | protein kinase C, eta type | | Authors: | Walker, J.R., Littler, D.R., Finerty Jr., P.J., MacKenzie, F., Newman, E.M., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-01-04 | | Release date: | 2006-01-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
Biochem.Biophys.Res.Commun., 349, 2006
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2YV7 | |
2YV9 | |
4L63 | | APO FORM OF AB5 HOLOTOXIN | | Descriptor: | ECXA, ECXB, ZINC ION, ... | | Authors: | Littler, D.R., Ng, N.M., Rossjohn, J., Beddoe, T. | | Deposit date: | 2013-06-11 | | Release date: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
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4L6T | | GM1 BOUND FORM OF THE ECX AB5 HOLOTOXIN | | Descriptor: | ECXA, ECXB, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... | | Authors: | Littler, D.R., Ng, N.M., Rossjohn, J., Beddoe, T. | | Deposit date: | 2013-06-12 | | Release date: | 2013-11-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.859 Å) | | Cite: | EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
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3BFO | | CRYSTAL STRUCTURE OF IG-LIKE C2-TYPE 2 DOMAIN OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1 | | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Isoform 2) | | Authors: | Walker, J.R., Akutsu, M., Littler, D.R., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-11-22 | | Release date: | 2007-12-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Structure of the Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1.
To be Published
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4P15 | | STRUCTURE OF THE CLPC N-TERMINAL DOMAIN FROM AN ALKALIPHILIC BACILLUS LEHENSIS G1 SPECIES | | Descriptor: | Bacillus lehensis ClpC N-terminal domain, SULFATE ION | | Authors: | Rashid, S.A., Littler, D.R., Illias, R.M., Murad, A.M.A., Rossjohn, J., Beddoe, T., Mahadi, N.M. | | Deposit date: | 2014-01-31 | | Release date: | 2014-07-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of the ClpC N-terminal domain at 1.85 Angstroms resolution from an alkaliphilic Bacillus lehensis G1 species
To Be Published
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2R4V | | STRUCTURE OF HUMAN CLIC2, CRYSTAL FORM A | | Descriptor: | Chloride intracellular channel protein 2, GLUTATHIONE | | Authors: | Hansen, G., Cromer, B.A., Gorman, M.A., Parker, M.W. | | Deposit date: | 2007-09-02 | | Release date: | 2007-11-13 | | Last modified: | 2011-12-21 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
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2R5G | | STRUCTURE OF HUMAN CLIC2, CRYSTAL FORM B | | Descriptor: | Chloride intracellular channel protein 2 | | Authors: | Gorman, M.A., Hansen, G., Cromer, B.A., Parker, M.W. | | Deposit date: | 2007-09-03 | | Release date: | 2007-11-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
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4PN6 | | STRUCTURE OF THE CYTOMEGALOVIRUS-ENCODED M04 GLYCOPROTEIN | | Descriptor: | M04, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Berry, R., Rossjohn, J. | | Deposit date: | 2014-05-23 | | Release date: | 2014-07-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins.
J.Biol.Chem., 289, 2014
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