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1M11
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STRUCTURAL MODEL OF HUMAN DECAY-ACCELERATING FACTOR BOUND TO ECHOVIRUS 7 FROM CRYO-ELECTRON MICROSCOPY
Descriptor:decay-accelerating factor, COAT PROTEIN VP1, COAT PROTEIN VP2, ...
Authors:He, Y., Lin, F., Chipman, P.R., Bator, C.M., Baker, T.S., Shoham, M., Kuhn, R.J., Medof, M.E., Rossmann, M.G.
Deposit date:2002-06-17
Release date:2002-08-28
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (16 Å)
Cite:Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex.
Proc.Natl.Acad.Sci.USA, 99, 2002
1NWV
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SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR
Descriptor:Complement decay-accelerating factor
Authors:Uhrinova, S., Lin, F., Ball, G., Bromek, K., Uhrin, D., Medof, M.E., Barlow, P.N.
Deposit date:2003-02-07
Release date:2003-04-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a functionally active fragment of decay-accelerating factor
Proc.Natl.Acad.Sci.USA, 100, 2003
1YZ3
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STRUCTURE OF HUMAN PNMT COMPLEXED WITH COFACTOR PRODUCT ADOHCY AND INHIBITOR SK&F 64139
Descriptor:Phenylethanolamine N-methyltransferase, 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Wu, Q., Gee, C.L., Lin, F., Martin, J.L., Grunewald, G.L., McLeish, M.J.
Deposit date:2005-02-27
Release date:2006-02-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
J.Med.Chem., 48, 2005
2AIZ
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SOLUTION STRUCTURE OF PEPTIDOGLYCAN ASSOCIATED LIPOPROTEIN FROM HAEMOPHILUS INFLUENZA BOUND TO UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMYL-MESO-2,6-DIAMINOPIMELOYL-D-ALANYL-D-ALANINE
Descriptor:Outer membrane protein P6, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
Authors:Parsons, L.M., Lin, F., Orban, J., Structure 2 Function Project (S2F)
Deposit date:2005-08-01
Release date:2006-03-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Peptidoglycan recognition by pal, an outer membrane lipoprotein.
Biochemistry, 45, 2006
2CH0
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SOLUTION STRUCTURE OF THE HUMAN MAN1 C-TERMINAL DOMAIN (RESIDUES 655- 775)
Descriptor:INNER NUCLEAR MEMBRANE PROTEIN MAN1
Authors:Caputo, S., Couprie, J., Duband-Goulet, I., Lin, F., Braud, S., Gondry, M., Worman, H.J., Gilquin, B., Zinn-Justin, S.
Deposit date:2006-03-10
Release date:2006-05-16
Last modified:2018-05-02
Method:SOLUTION NMR
Cite:The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain.
J. Biol. Chem., 281, 2006
2QZD
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FITTED STRUCTURE OF SCR4 OF DAF INTO CRYOEM DENSITY
Descriptor:Complement decay-accelerating factor
Authors:Hafenstein, S., Bowman, V.D., Chipman, P.R., Bator Kelly, C.M., Lin, F., Medof, M.E., Rossmann, M.G.
Deposit date:2007-08-16
Release date:2007-10-30
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
2QZF
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SCR1 OF DAF FROM 1OJV FITTED INTO CRYOEM DENSITY
Descriptor:Complement decay-accelerating factor
Authors:Hafenstein, S., Bowman, V.D., Chipman, P.R., Bator Kelly, C.M., Lin, F., Medof, M.E., Rossmann, M.G.
Deposit date:2007-08-16
Release date:2007-10-30
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
2QZH
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SCR2/3 OF DAF FROM THE NMR STRUCTURE 1NWV FITTED INTO A CRYOEM RECONSTRUCTION OF CVB3-RD COMPLEXED WITH DAF
Descriptor:Complement decay-accelerating factor
Authors:Hafenstein, S., Bowman, V.D., Chipman, P.R., Bator Kelly, C.M., Lin, F., Medof, M.E., Rossmann, M.G.
Deposit date:2007-08-16
Release date:2007-10-30
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
3IYP
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THE INTERACTION OF DECAY-ACCELERATING FACTOR WITH ECHOVIRUS 7
Descriptor:Capsid protein, Polyprotein, Complement decay-accelerating factor, ...
Authors:Plevka, P., Hafenstein, S., Zhang, Y., Harris, K.G., Cifuente, J.O., Bowman, V.D., Chipman, P.R., Lin, F., Medof, D.E., Bator, C.M., Rossmann, M.G.
Deposit date:2010-04-07
Release date:2010-11-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Interaction of decay-accelerating factor with echovirus 7.
J.Virol., 84, 2010
5FA5
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CRYSTAL STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH MTA AND H4 PEPTIDE
Descriptor:Protein arginine N-methyltransferase 5, Methylosome protein 50, Histone H4, ...
Authors:Sprague, E.R., McNamara, J.T.
Deposit date:2015-12-10
Release date:2016-02-24
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science, 351, 2016
1NL6
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CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR
Descriptor:Cathepsin K, 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE
Authors:Smith, W.W., Janson, C.A., Zhao, B.
Deposit date:2003-01-06
Release date:2003-01-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Azepanone-based inhibitors of human and rat cathepsin K
J.Med.Chem., 44, 2001
1NLJ
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CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR
Descriptor:CATHEPSIN K, BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[3-OXO-1-(PYRIDIN-2-YLSULFONYL)AZEPAN-4-YLCARBAMOYL]BUTYL}AMIDE
Authors:Smith, W.W., Janson, C.A., Zhao, B.
Deposit date:2003-01-07
Release date:2003-01-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azepanone-Based Inhibitors of Human and Rat Cathepsin K
J.Med.Chem., 44, 2001
2FHW
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SOLUTION STRUCTURE OF HUMAN RELAXIN-3
Descriptor:Relaxin 3 (Prorelaxin H3) (Insulin-like peptide INSL7) (Insulin-like peptide 7)
Authors:Rosengren, K.J., Craik, D.J.
Deposit date:2005-12-27
Release date:2006-01-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.
J.Biol.Chem., 281, 2006
2FTD
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CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH 7-METHYL-SUBSTITUTED AZEPAN-3-ONE COMPOUND
Descriptor:Cathepsin K, N-[(1S)-1-({[(3S,4S,7R)-3-HYDROXY-7-METHYL-1-(PYRIDIN-2-YLSULFONYL)-2,3,4,7-TETRAHYDRO-1H-AZEPIN-4-YL]AMINO}CARBONYL)-3-METHYLBUTYL]-1-BENZOFURAN-2-CARBOXAMIDE
Authors:Yamashita, D.S., Baoguang, Z.
Deposit date:2006-01-24
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors.
J.Med.Chem., 49, 2006
2H8B
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SOLUTION STRUCTURE OF INSL3
Descriptor:Insulin-like 3
Authors:Rosengren, K.J., Craik, D.J., Daly, N.L.
Deposit date:2006-06-07
Release date:2006-08-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Characterization of the LGR8 Receptor Binding Surface of Insulin-like Peptide 3
J.Biol.Chem., 281, 2006
2X5I
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CRYSTAL STRUCTURE ECHOVIRUS 7
Descriptor:VP1, VP2, VP3, ...
Authors:Plevka, P., Hafenstein, S., Zhang, Y., Bowman, V.D., Chipman, P.R., Bator, C.M., Rossmann, M.G.
Deposit date:2010-02-08
Release date:2010-12-22
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Interaction of Decay-Accelerating Factor with Echovirus 7.
J.Virol., 84, 2010
5SUN
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IDH1 R132H IN COMPLEX WITH IDH146
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-benzyl-N-[3-(dimethylsulfamoyl)phenyl]-4-oxo-3,4-dihydrophthalazine-1-carboxamide, ...
Authors:Xie, X., Kulathila, R.
Deposit date:2016-08-03
Release date:2017-02-08
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.477 Å)
Cite:Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
5SVF
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IDH1 R132H IN COMPLEX WITH IDH125
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one, ...
Authors:Xie, X., Kulathila, R.
Deposit date:2016-08-05
Release date:2017-02-08
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
5SVN
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STRUCTURE OF IDH2 MUTANT R172K
Descriptor:Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Xie, X., Kulathila, R.
Deposit date:2016-08-06
Release date:2017-02-08
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
5SVO
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STRUCTURE OF IDH2 MUTANT R140Q
Descriptor:Isocitrate dehydrogenase [NADP], mitochondrial, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Xie, X., Kulathila, R.
Deposit date:2016-08-06
Release date:2017-02-08
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
5TQH
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IDH1 R132H MUTANT IN COMPLEX WITH IDH889
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, CITRATE ANION, (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one, ...
Authors:Xie, X., Kulathila, R.
Deposit date:2016-10-24
Release date:2017-01-25
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.
ACS Med Chem Lett, 8, 2017
6F4U
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CRYSTAL STRUCTURE OF REACTIVE LOOP CLEAVED KALLISTATIN AT 1.9 ANGSTROM RESOLUTION
Descriptor:Kallistatin, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Zhou, A., Wei, Z., Lin, F.
Deposit date:2017-11-30
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human Kallistatin
To Be Published