Author results

5GZN
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
Descriptor:Genome polyprotein, Antibody Heavy chain, Antibody light chain
Authors:Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2016-09-29
Release date:2016-12-28
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
5GZO
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
Descriptor:Genome polyprotein, Antibody heavy chain, Antibody light chain
Authors:Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2016-09-29
Release date:2017-01-18
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.755 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
4XX5
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STRUCTURE OF PI3K GAMMA IN COMPLEX WITH AN INHIBITOR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-[5-(5-methoxypyridin-3-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide
Authors:Collier, P.N., Messersmith, D., Le Tiran, A., Bandarage, U.K., Boucher, C., Come, J., Cottrell, K.M., Damagnez, V., Doran, J.D., Griffith, J.P., Khare-Pandit, S., Krueger, E.B., Ledeboer, M.W., Ledford, B., Liao, Y., Mahajan, S., Moody, C.S., Wang, T., Xu, J., Aronov, A.M.
Deposit date:2015-01-29
Release date:2015-08-05
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure of PI3K gamma in complex with an inhibitor
To Be Published
4XZ4
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STRUCTURE OF PI3K GAMMA IN COMPLEX WITH AN INHIBITOR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-[5-(6-methoxypyrazin-2-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide
Authors:Collier, P.N., Messersmith, D., Le Tiran, A., Bandarage, U.K., Boucher, C., Come, J., Cottrell, K.M., Damagnez, V., Doran, J.D., Griffith, J.P., Khare-Pandit, S., Krueger, E.B., Ledeboer, M.W., Ledford, B., Liao, Y., Mahajan, S., Moody, C.S., Wang, T., Xu, J., Aronov, A.M.
Deposit date:2015-02-03
Release date:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of PI3K gamma in complex with an inhibitor
To Be Published
4P8O
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S. AUREUS GYRASE BOUND TO AN AMINOBENZIMIDAZOLE UREA INHIBITOR
Descriptor:DNA gyrase subunit B, 1-ethyl-3-[5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzimidazol-2-yl]urea
Authors:Jacobs, M.D.
Deposit date:2014-03-31
Release date:2014-10-29
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.
J.Med.Chem., 57, 2014
5GZR
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ZIKA VIRUS E PROTEIN COMPLEXED WITH A NEUTRALIZING ANTIBODY Z23-FAB
Descriptor:structural protein E, strutural protein M, Z23 Fab heavy chain, ...
Authors:Gao, G.G., Shi, Y., Peng, R., Liu, S.
Deposit date:2016-10-01
Release date:2016-11-30
Last modified:2016-12-28
Method:ELECTRON MICROSCOPY (9.4 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
2MFJ
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SOLUTION STRUCTURE OF BLO T 19, A MINOR DUST MITE ALLERGEN FROM BLOMIA TROPICALIS
Descriptor:Blo t 19
Authors:Naik, M.T., Naik, N., Huang, T.
Deposit date:2013-10-15
Release date:2014-11-19
Method:SOLUTION NMR
Cite:Solution structure of Blo 1 19
To be Published
4N78
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THE WAVE REGULATORY COMPLEX LINKS DIVERSE RECEPTORS TO THE ACTIN CYTOSKELETON
Descriptor:Cytoplasmic FMR1-interacting protein 1, Nck-associated protein 1, Wiskott-Aldrich syndrome protein family member 1, ...
Authors:Chen, Z.C.
Deposit date:2013-10-15
Release date:2014-02-05
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.
Cell(Cambridge,Mass.), 156, 2014
5H2S
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SOLUTION STRUCTURE OF TILAPIA PISCIDIN 4 (TP4) FROM OREOCHROMIS NILOTICUS
Descriptor:Piscidin-4
Authors:Wei, S., Chen, C.
Deposit date:2016-10-17
Release date:2017-10-25
Method:SOLUTION NMR
Cite:Solution structure of Tilapia piscidin 4, an antimicrobial peptide effective against multidrug resistant Helicobacter pylori
To Be Published
6C1S
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PHOSPHOINOSITIDE 3-KINASE GAMMA BOUND TO AN PYRROLOPYRIDINONE INHIBITOR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile, SULFATE ION
Authors:Jacobs, M.D., Griffin, J.P.
Deposit date:2018-01-05
Release date:2018-06-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
J. Med. Chem., 61, 2018