6P25 | |
6P28 | |
6P2R | |
6IO4 | |
6IO6 | |
6IOJ | |
6P3P | | CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 65 | | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, methyl N-(5-{[2-chloro-5-(trifluoromethyl)phenyl]sulfamoyl}-4-methylthiophene-2-carbonyl)-D-phenylalaninate | | Authors: | Toms, A.V., Follows, B. | | Deposit date: | 2019-05-24 | | Release date: | 2019-07-03 | | Last modified: | 2019-07-10 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors.
Bioorg.Med.Chem.Lett., 2019
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6JCN | | YEAST DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 | | Descriptor: | Dehydrodolichyl diphosphate synthase complex subunit NUS1, SULFATE ION | | Authors: | Ko, T.-P., Ma, J., Liu, W., Chen, C.-C., Guo, R.-T. | | Deposit date: | 2019-01-29 | | Release date: | 2019-06-19 | | Last modified: | 2019-07-10 | | Method: | X-RAY DIFFRACTION (1.998 Å) | | Cite: | Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1.
Biochem.Biophys.Res.Commun., 515, 2019
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6BS3 | |
6BS4 | |
6BS5 | |
6IG9 | |
6J3O | | CRYSTAL STRUCTURE OF THE HUMAN PCAF BROMODOMAIN IN COMPLEX WITH COMPOUND 12 | | Descriptor: | Histone acetyltransferase KAT2B, 3-methyl-2-[[(3~{R})-1-methylpiperidin-3-yl]amino]-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one | | Authors: | Huang, L.Y., Li, H., Li, L.L., Niu, L., Seupel, R., Wu, C.Y., Li, G.B., Yu, Y.M., Brennan, P.E., Yang, S.Y. | | Deposit date: | 2019-01-05 | | Release date: | 2019-05-01 | | Last modified: | 2019-05-22 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 62, 2019
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6J3P | | CRYSTAL STRUCTURE OF THE HUMAN GCN5 BROMODOMAIN IN COMPLEX WITH COMPOUND (R,R)-36N | | Descriptor: | Histone acetyltransferase KAT2A, 2-{[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpiperidin-3-yl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | | Authors: | Huang, L.Y., Li, H., Niu, L., Wu, C.Y., Yu, Y.M., Li, L.L., Yang, S.Y. | | Deposit date: | 2019-01-05 | | Release date: | 2019-05-01 | | Last modified: | 2019-05-22 | | Method: | X-RAY DIFFRACTION (1.598 Å) | | Cite: | Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 62, 2019
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5ZGC | |
5ZJW | | CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZG353 | | Descriptor: | Serine/threonine-protein kinase PAK 4, (3Z)-N-[(1S)-2-hydroxy-1-phenylethyl]-3-[(1H-imidazol-2-yl)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, 1,2-ETHANEDIOL, ... | | Authors: | Zhao, F., Li, H. | | Deposit date: | 2018-03-22 | | Release date: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Crystal Structure of PAK4 in complex with inhibitor CZg353
To be published
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5ZID | | CRYSTAL STRUCTURE OF HUMAN DPP-IV IN COMPLEX WITH HL2 | | Descriptor: | Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, (2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile, ... | | Authors: | Zhu, L., Li, H., Wu, F. | | Deposit date: | 2018-03-14 | | Release date: | 2019-03-20 | | Last modified: | 2019-04-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure of human DPP-IV in complex with HL2
To Be Published
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6J69 | | STRUCTURE OF KIBRA AND DENDRIN COMPLEX | | Descriptor: | Protein KIBRA, Peptide from Dendrin | | Authors: | Lin, Z., Yang, Z., Ji, Z., Zhang, M. | | Deposit date: | 2019-01-14 | | Release date: | 2019-03-20 | | Method: | X-RAY DIFFRACTION (2.753 Å) | | Cite: | Kibra Modulates Learning and Memory via Binding to Dendrin.
Cell Rep, 26, 2019
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6NG1 | |
6NG2 | |
6NG4 | |
6NG5 | |
6NG6 | |
6NG7 | |
6NG8 | |
