Author results

6WPG
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STRUCTURAL BASIS OF SALICYLIC ACID PERCEPTION BY ARABIDOPSIS NPR PROTEINS
Descriptor:Regulatory protein NPR4, 2-HYDROXYBENZOIC ACID
Authors:Wang, W., Withers, J., Li, H., Zwack, P.J., Rusnac, D.V., Shi, H., Liu, L., Yan, S., Hinds, T.R., Guttman, M., Dong, X., Zheng, N.
Deposit date:2020-04-27
Release date:2020-08-12
Method:X-RAY DIFFRACTION (2.283 Å)
Cite:Structural Basis of Salicylic Acid Perception by Arabidopsis NPR Proteins
Nature, 2020
6LKV
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STRUCTURAL AND FUNCTIONAL INSIGHTS INTO MACROPHAGE MIGRATION INHIBITORY FACTOR FROM ONCOMELANIA HUPENSIS, THE INTERMEDIATE HOST OF SCHISTOSOMA JAPONICUM
Descriptor:Macrophage migration inhibitory factor, CHLORIDE ION, SULFATE ION
Authors:Su, Z.M., Tian, X.Y., Li, H.J., Wei, Z.M., Chen, L.F., Ren, H.X., Peng, W.F., Tang, C.T.
Deposit date:2019-12-20
Release date:2020-07-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.
Biochem.J., 477, 2020
6LKW
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STRUCTURAL AND FUNCTIONAL INSIGHTS INTO MACROPHAGE MIGRATION INHIBITORY FACTOR FROM ONCOMELANIA HUPENSIS, THE INTERMEDIATE HOST OF SCHISTOSOMA JAPONICUM
Descriptor:Macrophage migration inhibitory factor, CHLORIDE ION
Authors:Su, Z.M., Tian, X.Y., Li, H.J., Wei, Z.M., Chen, L.F., Ren, H.X., Peng, W.F., Tang, C.T.
Deposit date:2019-12-20
Release date:2020-07-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.
Biochem.J., 477, 2020
6LR3
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STRUCTURAL AND FUNCTIONAL INSIGHTS INTO MACROPHAGE MIGRATION INHIBITORY FACTOR FROM ONCOMELANIA HUPENSIS, THE INTERMEDIATE HOST OF SCHISTOSOMA JAPONICUM
Descriptor:Macrophage migration inhibitory factor, SULFATE ION
Authors:Su, Z.M., Tian, X.Y., Li, H.J., Wei, Z.M., Chen, L.F., Ren, H.X., Peng, W.F., Tang, C.T.
Deposit date:2020-01-15
Release date:2020-07-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.
Biochem.J., 477, 2020
6WGC
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ATOMIC MODEL OF SEMI-ATTACHED MUTANT OCCM-DNA COMPLEX (ORC-CDC6-CDT1-MCM2-7 WITH MCM6 WHD TRUNCATION)
Descriptor:Cell division control protein 6, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-08-12
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WGF
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ATOMIC MODEL OF MUTANT MCM2-7 HEXAMER WITH MCM6 WHD TRUNCATION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM7, DNA replication licensing factor MCM6, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-08-12
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WGG
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ATOMIC MODEL OF PRE-INSERTION MUTANT OCCM-DNA COMPLEX(ORC-CDC6-CDT1-MCM2-7 WITH MCM6 WHD TRUNCATION)
Descriptor:Cell division cycle protein CDT1, Cell division control protein 6, Origin recognition complex subunit 1, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-08-12
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WGI
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ATOMIC MODEL OF THE MUTANT OCCM (ORC-CDC6-CDT1-MCM2-7 WITH MCM6 WHD TRUNCATION) LOADED ON DNA AT 10.5 A RESOLUTION
Descriptor:DNA (34-MER), Cell division control protein 6, Origin recognition complex subunit 1, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-08-12
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6KDQ
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CRYSTAL STRUCTURE OF HUMAN NRMT1 IN COMPLEX WITH ALPHA-N-MONOMETHYLATED HUMAN CENP-A PEPTIDE
Descriptor:N-terminal Xaa-Pro-Lys N-methyltransferase 1, CENP-A peptide, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Yue, Y., Li, H.
Deposit date:2019-07-02
Release date:2020-07-08
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Substrate engagement regulates state-specific alpha-N methylation of CENP-A by NRMT2
to be published
6KDR
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CRYSTAL STRUCTURE OF HUMAN NRMT2 IN COMPLEX WITH HUMAN CENTROMERE PROTEIN B PEPTIDE
Descriptor:Alpha N-terminal protein methyltransferase 1B, Peptide from Major centromere autoantigen B, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Yue, Y., Li, H.
Deposit date:2019-07-02
Release date:2020-07-08
Method:X-RAY DIFFRACTION (2.112 Å)
Cite:Substrate-enzyme engagement regulates state-specific alpha-N methylation of NRMT2
to be published
6KDS
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CRYSTAL STRUCTURE OF HUMAN NRMT2 IN COMPLEX WITH ALPHA-N-MONOMETHYLATED HUMAN CENP-A PEPTIDE
Descriptor:Alpha N-terminal protein methyltransferase 1B, CENP-A peptide, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Yue, Y., Li, H.
Deposit date:2019-07-02
Release date:2020-07-08
Method:X-RAY DIFFRACTION (1.844 Å)
Cite:Substrate engagement regulates state-specific alpha-N methylation of CENP-A by NRMT2
To be published
6WJV
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STRUCTURE OF THE SACCHAROMYCES CEREVISIAE POLYMERASE EPSILON HOLOENZYME
Descriptor:DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ...
Authors:Yuan, Z., Georgescu, R., Schauer, G.D., O'Donnell, M., Li, H.
Deposit date:2020-04-14
Release date:2020-07-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome.
Nat Commun, 11, 2020
6WB9
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STRUCTURE OF THE S. CEREVISIAE ER MEMBRANE COMPLEX
Descriptor:Endoplasmic reticulum membrane protein complex subunit 10, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ...
Authors:Bai, L., Li, H.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the ER membrane complex, a transmembrane-domain insertase.
Nature, 2020
6WEJ
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STRUCTURE OF CGMP-UNBOUND WT TAX-4 RECONSTITUTED IN LIPID NANODISCS
Descriptor:Cyclic nucleotide-gated cation channel, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ...
Authors:Zheng, X., Fu, Z., Su, D., Zhang, Y., Li, M., Pan, Y., Li, H., Li, S., Grassucci, R.A., Ren, Z., Hu, Z., Li, X., Zhou, M., Li, G., Frank, J., Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6WEK
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STRUCTURE OF CGMP-BOUND WT TAX-4 RECONSTITUTED IN LIPID NANODISCS
Descriptor:Cyclic nucleotide-gated cation channel, CYCLIC GUANOSINE MONOPHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Zheng, X., Fu, Z., Su, D., Zhang, Y., Li, M., Pan, Y., Li, H., Li, S., Grassucci, R.A., Ren, Z., Hu, Z., Li, X., Zhou, M., Li, G., Frank, J., Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6WEL
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STRUCTURE OF CGMP-UNBOUND F403V/V407A MUTANT TAX-4 RECONSTITUTED IN LIPID NANODISCS
Descriptor:Cyclic nucleotide-gated cation channel, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ...
Authors:Zheng, X., Fu, Z., Su, D., Zhang, Y., Li, M., Pan, Y., Li, H., Li, S., Grassucci, R.A., Ren, Z., Hu, Z., Li, X., Zhou, M., Li, G., Frank, J., Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6L0O
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WH DOMAIN OF HUMAN MCM8
Descriptor:DNA helicase MCM8, SULFATE ION
Authors:Liu, Y., Li, J., Liu, L., Zeng, H.
Deposit date:2019-09-26
Release date:2020-04-29
Last modified:2020-06-03
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Crystal structure of the winged-helix domain of MCM8.
Biochem.Biophys.Res.Commun., 526, 2020
6PMV
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(4-(2-AMINOETHYL)PHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6PMW
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(4-(AMINOMETHYL)PHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.748 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6PMX
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(3-(2-AMINOETHYL)PHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6PMY
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(3-(2-AMINOETHYL)PHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6PMZ
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(5-(AMINOMETHYL)PYRIDIN-3-YL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6PN0
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(3-(AMINOMETHYL)-4-ETHOXYPHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (2.229 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6PN1
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(3-(AMINOMETHYL)-4-PROPOXYPHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6PN2
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(3-(AMINOMETHYL)-4-ISOPROPOXYPHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2019-07-02
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.877 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
167518
数据于2020-08-12公开中