Author results

2ABO
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NMR STRUCTURE OF GAMMA HERPESVIRUS 68 A VIRAL BCL-2 HOMOLOG
Descriptor:bcl-2 homolog
Authors:Loh, J., Huang, Q., Petros, A.M., Nettesheim, D., van Dyk, L.F., Labrada, L., Speck, S.H., Levine, B., Olejniczak, E.T., Virgin, H.W.
Deposit date:2005-07-15
Release date:2006-05-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A surface groove essential for viral Bcl-2 function during chronic infection in vivo.
Plos Pathog., 1, 2005
5VHG
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CRYSTAL STRUCTURE OF PENTAD MUTANT GAPR-1
Descriptor:Golgi-associated plant pathogenesis-related protein 1, SULFATE ION
Authors:Li, Y., Zhao, Y., Su, M., Chakravarthy, S., Colbert, C.L., Levine, B., Sinha, S.C.
Deposit date:2017-04-13
Release date:2017-09-20
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein.
Acta Crystallogr D Struct Biol, 73, 2017
4U93
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CRYSTAL STRUCTURE OF HSP90-ALPHA N-DOMAIN BOUND TO THE INHIBITOR NVP-HSP990
Descriptor:Heat shock protein HSP 90-alpha, (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one
Authors:Bellamacina, C.R., Shafer, C.M., Bussiere, D.
Deposit date:2014-08-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.
J.Med.Chem., 57, 2014
4W7T
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CRYSTAL STRUCTURE OF HSP90-ALPHA N-DOMAIN BOUND TO THE INHIBITOR NVP-HSP990
Descriptor:Heat shock protein HSP 90-alpha, (7S)-2-amino-4-methyl-7-phenyl-7,8-dihydroquinazolin-5(6H)-one
Authors:Bellamacina, C.R., Shafer, C.M., Bussiere, D.
Deposit date:2014-08-22
Release date:2014-11-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.
J.Med.Chem., 57, 2014
3DVU
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CRYSTAL STRUCTURE OF THE COMPLEX OF MURINE GAMMA-HERPESVIRUS 68 BCL-2 HOMOLOG M11 AND THE BECLIN 1 BH3 DOMAIN
Descriptor:V-bcl-2, Beclin-1
Authors:Sinha, S.
Deposit date:2008-07-20
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11
Autophagy, 4, 2008
4MI8
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CRYSTAL STRUCTURE OF THE COMPLEX OF MURINE GAMMA-HERPESVIRUS 68 BCL-2 HOMOLOG M11 AND A BECLIN 1 BH3 DOMAIN-DERIVED PEPTIDE
Descriptor:Bcl-2 homolog (Gene 16?), Beclin-1, SULFATE ION
Authors:Su, M., Mei, Y., Sinha, S.
Deposit date:2013-08-30
Release date:2014-01-29
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Targeting gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.
J.Biol.Chem., 289, 2014
5CT7
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BRAF IN COMPLEX WITH RAF265
Descriptor:Serine/threonine-protein kinase B-raf, 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Authors:Appleton, B.A.
Deposit date:2015-07-23
Release date:2015-09-09
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Acs Med.Chem.Lett., 6, 2015
5K7B
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BECLIN 2 CCD HOMODIMER
Descriptor:Beclin-2
Authors:Su, M., Sinha, S.
Deposit date:2016-05-25
Release date:2017-03-08
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.
Protein Sci., 26, 2017
5K9L
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BECLIN 2 CCD N187L MUTANT HOMODIMER
Descriptor:Beclin-2
Authors:Su, M., Sinha, S.
Deposit date:2016-06-01
Release date:2017-03-08
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.
Protein Sci., 26, 2017
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