Author results

1PS1
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PENTALENENE SYNTHASE
分子名称:PENTALENENE SYNTHASE, TRIMETHYL LEAD ION
著者Lesburg, C.A., Christianson, D.W.
登録日1997-03-23
公開日1998-03-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology.
Science, 277, 1997
1H4N
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H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS
分子名称:CARBONIC ANHYDRASE II, ZINC ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Lesburg, C.A., Christianson, D.W.
登録日1997-05-29
公開日1997-09-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Biochemistry, 36, 1997
1H9N
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H119N CARBONIC ANHYDRASE II
分子名称:CARBONIC ANHYDRASE II, ZINC ION
著者Lesburg, C.A., Christianson, D.W.
登録日1997-05-29
公開日1997-09-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Biochemistry, 36, 1997
1H9Q
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H119Q CARBONIC ANHYDRASE II
分子名称:CARBONIC ANHYDRASE II, ZINC ION
著者Lesburg, C.A., Christianson, D.W.
登録日1997-05-29
公開日1997-09-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Biochemistry, 36, 1997
2H4N
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H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
分子名称:CARBONIC ANHYDRASE II, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
著者Lesburg, C.A., Christianson, D.W.
登録日1997-05-29
公開日1997-09-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Biochemistry, 36, 1997
1CNG
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X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
分子名称:CARBONIC ANHYDRASE II, ZINC ION, CHLORIDE ION
著者Lesburg, C.A., Christianson, D.W.
登録日1995-04-03
公開日1995-07-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CNH
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X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
分子名称:CARBONIC ANHYDRASE II, ZINC ION
著者Lesburg, C.A., Christianson, D.W.
登録日1995-04-03
公開日1995-07-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CNI
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X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
分子名称:CARBONIC ANHYDRASE II, ZINC ION, MERCURY (II) ION
著者Lesburg, C.A., Christianson, D.W.
登録日1995-04-03
公開日1995-07-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CNJ
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X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
分子名称:CARBONIC ANHYDRASE II, ZINC ION, MERCURY (II) ION
著者Lesburg, C.A., Christianson, D.W.
登録日1995-04-03
公開日1995-07-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CNK
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X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
分子名称:CARBONIC ANHYDRASE II, ZINC ION, SULFATE ION
著者Lesburg, C.A., Christianson, D.W.
登録日1995-04-03
公開日1995-07-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1C2P
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE
分子名称:RNA-DEPENDENT RNA POLYMERASE
著者Lesburg, C.A., Cable, M.B., Ferrari, E., Hong, Z., Mannarino, A.F., Weber, P.C.
登録日1999-07-26
公開日2000-04-05
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site.
Nat.Struct.Biol., 6, 1999
1ZSA
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CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM
分子名称:CARBONIC ANHYDRASE II
著者Lesburg, C.A., Christianson, D.W.
登録日1996-01-09
公開日1996-07-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
Biochemistry, 35, 1996
1ZSB
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CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE
分子名称:CARBONIC ANHYDRASE II, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
著者Lesburg, C.A., Christianson, D.W.
登録日1996-01-09
公開日1996-07-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
Biochemistry, 35, 1996
1ZSC
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CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM
分子名称:CARBONIC ANHYDRASE II, ZINC ION
著者Lesburg, C.A., Christianson, D.W.
登録日1996-01-09
公開日1996-07-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
Biochemistry, 35, 1996
3CTB
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TETHERED PXR-LBD/SRC-1P APOPROTEIN
分子名称:Pregnane X receptor, Linker, Steroid receptor coactivator 1
著者Lesburg, C.A.
登録日2008-04-11
公開日2008-12-02
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Protein Eng.Des.Sel., 21, 2008
3HVL
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TETHERED PXR-LBD/SRC-1P COMPLEXED WITH SR-12813
分子名称:Pregnane X receptor, Linker, Steroid receptor coactivator 1, ...
著者Lesburg, C.A., Wang, W., Prosise, W.W., Chen, J., Taremi, S.S., Le, H.V., Madison, V., Cui, X., Thomas, A., Cheng, K.C.
登録日2009-06-16
公開日2009-08-04
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Protein Eng.Des.Sel., 21, 2008
3LKH
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INHIBITORS OF HEPATITIS C VIRUS POLYMERASE: SYNTHESIS AND CHARACTERIZATION OF NOVEL 6-FLUORO-N-[2-HYDROXY-1(S)-BENZAMIDES
分子名称:RNA-directed RNA polymerase, 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide
著者Lesburg, C.A.
登録日2010-01-27
公開日2010-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Bioorg.Med.Chem.Lett., 20, 2010
3SKA
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I. NOVEL HCV NS5B POLYMERASE INHIBITORS: DISCOVERY OF INDOLE 2- CARBOXYLIC ACIDS WITH C3-HETEROCYCLES
分子名称:HCV NS5B RNA_DEPENDENT RNA POLYMERASE, PHOSPHATE ION, 1-[(2-aminopyridin-4-yl)methyl]-3-(2-oxo-1,2-dihydropyridin-3-yl)-5-(trifluoromethyl)-1H-indole-2-carboxylic acid
著者Lesburg, C.A., Anilkumar, G.N.
登録日2011-06-22
公開日2011-08-31
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
Bioorg.Med.Chem.Lett., 21, 2011
3SKE
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I. NOVEL HCV NS5B POLYMERASE INHIBITORS: DISCOVERY OF INDOLE 2- CARBOXYLIC ACIDS WITH C3-HETEROCYCLES
分子名称:HCV NS5B RNA_DEPENDENT RNA POLYMERASE, PHOSPHATE ION, 1-[(2-aminopyridin-4-yl)methyl]-3-(2,4-dioxo-1,2-dihydrothieno[3,4-d]pyrimidin-3(4H)-yl)-5-(trifluoromethyl)-1H-indole-2-carboxylic acid
著者Lesburg, C.A., Anilkumar, G.N.
登録日2011-06-22
公開日2011-08-31
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
Bioorg.Med.Chem.Lett., 21, 2011
3SKH
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I. NOVEL HCV NS5B POLYMERASE INHIBITORS: DISCOVERY OF INDOLE 2- CARBOXYLIC ACIDS WITH C3-HETEROCYCLES
分子名称:HCV NS5B RNA_DEPENDENT RNA POLYMERASE, 1-benzyl-5-chloro-3-(2-fluorophenyl)-1H-indole-2-carboxylic acid
著者Lesburg, C.A., Anilkumar, G.N.
登録日2011-06-22
公開日2011-08-31
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
Bioorg.Med.Chem.Lett., 21, 2011
3TYQ
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SAR DEVELOPMENT AND DISCOVERY OF POTENT INDOLE-BASED INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE
分子名称:RNA-directed RNA polymerase, 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION
著者Lesburg, C.A., Chen, K.X.
登録日2011-09-26
公開日2012-02-01
最終更新日2012-03-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors.
J.Med.Chem., 55, 2012
3TYV
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SAR DEVELOPMENT AND DISCOVERY OF POTENT INDOLE-BASED INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE
分子名称:RNA-directed RNA polymerase, PHOSPHATE ION, N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide
著者Lesburg, C.A., Chen, K.X.
登録日2011-09-26
公開日2012-02-01
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase.
J.Med.Chem., 55, 2012
5W2E
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HCV NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR MK-8876
分子名称:Genome polyprotein, 2-(4-fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide
著者Lesburg, C.A., Ummat, A.
登録日2017-06-06
公開日2017-08-16
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876.
ChemMedChem, 12, 2017
5WO4
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JAK1 COMPLEXED WITH COMPOUND 28
分子名称:Tyrosine-protein kinase JAK1, 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]-1H-pyrazole-4-carboxamide
著者Lesburg, C.A., Patel, S.B.
登録日2017-08-01
公開日2017-12-06
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
J. Med. Chem., 60, 2017
6MX0
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CRYSTAL STRUCTURE OF HUMAN STING APOPROTEIN (G230A, H232R, R293Q)
分子名称:Stimulator of interferon genes protein, CALCIUM ION
著者Lesburg, C.A., Siu, T., Ho, T.
登録日2018-10-30
公開日2018-12-19
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
ACS Med Chem Lett, 10, 2019
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