Author results

3IKL
  • Download 3ikl
  • View 3ikl
Molmil generated image of 3ikl
CRYSTAL STRUCTURE OF POL GB DELTA-I4.
Descriptor:DNA polymerase subunit gamma-2, mitochondrial
Authors:Lee, Y.S., Kennedy, W.D., Yin, Y.W.
Deposit date:2009-08-06
Release date:2010-08-25
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Cell(Cambridge,Mass.), 139, 2009
2O5K
  • Download 2o5k
  • View 2o5k
Molmil generated image of 2o5k
CRYSTAL STRUCTURE OF GSK3BETA IN COMPLEX WITH A BENZOIMIDAZOL INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, 2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID [2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-AMIDE
Authors:Shin, D., Lee, S.C., Heo, Y.S., Cho, Y.S., Kim, Y.E., Hyun, Y.L., Cho, J.M., Lee, Y.S., Ro, S.
Deposit date:2006-12-06
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta
Bioorg.Med.Chem.Lett., 17, 2007
1OR0
  • Download 1or0
  • View 1or0
Molmil generated image of 1or0
CRYSTAL STRUCTURES OF GLUTARYL 7-AMINOCEPHALOSPORANIC ACID ACYLASE: INSIGHT INTO AUTOPROTEOLYTIC ACTIVATION
Descriptor:Glutaryl 7-Aminocephalosporanic Acid Acylase, glutaryl acylase, 1,2-ETHANEDIOL
Authors:Kim, J.K., Yang, I.S., Rhee, S., Dauter, Z., Lee, Y.S., Park, S.S., Kim, K.H.
Deposit date:2003-03-11
Release date:2004-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Glutaryl 7-Aminocephalosporanic Acid Acylase: Insight into Autoproteolytic Activation
Biochemistry, 42, 2003
1YRT
  • Download 1yrt
  • View 1yrt
Molmil generated image of 1yrt
CRYSTAL STRUCTURE ANALYSIS OF THE ADENYLYL CYCLAES CATALYTIC DOMAIN OF ADENYLYL CYCLASE TOXIN OF BORDETELLA PERTUSSIS IN PRESENCE OF C-TERMINAL CALMODULIN
Descriptor:Bifunctional hemolysin-adenylate cyclase, Calmodulin, CALCIUM ION
Authors:Guo, Q., Shen, Y., Lee, Y.S., Gibbs, C.S., Mrksich, M., Tang, W.J.
Deposit date:2005-02-04
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
3R5L
  • Download 3r5l
  • View 3r5l
Molmil generated image of 3r5l
STRUCTURE OF DDN, THE DEAZAFLAVIN-DEPENDENT NITROREDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS INVOLVED IN BIOREDUCTIVE ACTIVATION OF PA-824
Descriptor:Deazaflavin-dependent nitroreductase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayyar, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
Deposit date:2011-03-18
Release date:2012-01-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Structure, 20, 2012
3R5P
  • Download 3r5p
  • View 3r5p
Molmil generated image of 3r5p
STRUCTURE OF DDN, THE DEAZAFLAVIN-DEPENDENT NITROREDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS INVOLVED IN BIOREDUCTIVE ACTIVATION OF PA-824
Descriptor:Deazaflavin-dependent nitroreductase, SULFATE ION
Authors:Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayya, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
Deposit date:2011-03-19
Release date:2012-01-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Structure, 20, 2012
3R5R
  • Download 3r5r
  • View 3r5r
Molmil generated image of 3r5r
STRUCTURE OF DDN, THE DEAZAFLAVIN-DEPENDENT NITROREDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS INVOLVED IN BIOREDUCTIVE ACTIVATION OF PA-824, WITH CO-FACTOR F420
Descriptor:Deazaflavin-dependent nitroreductase, COENZYME F420
Authors:Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayya, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
Deposit date:2011-03-19
Release date:2012-01-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Structure, 20, 2012
3R5W
  • Download 3r5w
  • View 3r5w
Molmil generated image of 3r5w
STRUCTURE OF DDN, THE DEAZAFLAVIN-DEPENDENT NITROREDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS INVOLVED IN BIOREDUCTIVE ACTIVATION OF PA-824, WITH CO-FACTOR F420
Descriptor:Deazaflavin-dependent nitroreductase, COENZYME F420
Authors:Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayya, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
Deposit date:2011-03-20
Release date:2012-01-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.786 Å)
Cite:Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Structure, 20, 2012
3R5Y
  • Download 3r5y
  • View 3r5y
Molmil generated image of 3r5y
STRUCTURE OF A DEAZAFLAVIN-DEPENDENT NITROREDUCTASE FROM NOCARDIA FARCINICA, WITH CO-FACTOR F420
Descriptor:Putative uncharacterized protein, COENZYME F420
Authors:Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayya, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
Deposit date:2011-03-20
Release date:2012-01-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Structure, 20, 2012
3R5Z
  • Download 3r5z
  • View 3r5z
Molmil generated image of 3r5z
STRUCTURE OF A DEAZAFLAVIN-DEPENDENT REDUCTASE FROM NOCARDIA FARCINICA, WITH CO-FACTOR F420
Descriptor:Putative uncharacterized protein, COENZYME F420, SULFATE ION
Authors:Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayya, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
Deposit date:2011-03-20
Release date:2012-01-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Structure, 20, 2012
5KT2
  • Download 5kt2
  • View 5kt2
Molmil generated image of 5kt2
TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(26-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MG2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.488 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT3
  • Download 5kt3
  • View 5kt3
Molmil generated image of 5kt3
TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(26-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MN2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT4
  • Download 5kt4
  • View 5kt4
Molmil generated image of 5kt4
TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA R96G INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MG2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT5
  • Download 5kt5
  • View 5kt5
Molmil generated image of 5kt5
TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA R96G INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MN2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT6
  • Download 5kt6
  • View 5kt6
Molmil generated image of 5kt6
TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(1-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MG2+
Descriptor:DNA (5'-D(P*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT7
  • Download 5kt7
  • View 5kt7
Molmil generated image of 5kt7
TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(1-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MN2+
Descriptor:DNA (5'-D(P*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.151 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
3IKM
  • Download 3ikm
  • View 3ikm
Molmil generated image of 3ikm
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL DNA POLYMERASE HOLOENZYME
Descriptor:DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2
Authors:Lee, Y.-S., Kennedy, W.D., Yin, Y.W.
Deposit date:2009-08-06
Release date:2009-11-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Cell(Cambridge,Mass.), 139, 2009
4XVI
  • Download 4xvi
  • View 4xvi
Molmil generated image of 4xvi
BINARY COMPLEX OF HUMAN POLYMERASE NU AND DNA WITH THE FINGER DOMAIN AJAR
Descriptor:DNA polymerase nu, DNA (5'-D(*AP*CP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*CP*AP*G)-3')
Authors:Lee, Y.-S., Yang, W.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Nat.Struct.Mol.Biol., 22, 2015
4XVK
  • Download 4xvk
  • View 4xvk
Molmil generated image of 4xvk
BINARY COMPLEX OF HUMAN POLYMERASE NU AND DNA WITH THE FINGER DOMAIN CLOSED
Descriptor:DNA polymerase nu, DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*CP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*GP*TP*AP*GP*CP*GP*TP*CP*A)-3'), ...
Authors:Lee, Y.-S., Yang, W.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Nat.Struct.Mol.Biol., 22, 2015
4XVL
  • Download 4xvl
  • View 4xvl
Molmil generated image of 4xvl
BINARY COMPLEX OF HUMAN POLYMERASE NU AND DNA WITH THE FINGER DOMAIN OPEN
Descriptor:DNA polymerase nu, DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*AP*GP*CP*GP*TP*CP*A)-3'), ...
Authors:Lee, Y.-S., Yang, W.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Nat.Struct.Mol.Biol., 22, 2015
4XVM
  • Download 4xvm
  • View 4xvm
Molmil generated image of 4xvm
BINARY COMPLEX OF HUMAN POLYMERASE NU AND DNA WITH THE FINGER DOMAIN CLOSED AND THUMB DOMAIN ROTATED OUT
Descriptor:DNA polymerase nu, DNA (5'-D(*CP*TP*AP*GP*CP*GP*TP*CP*A)-3'), DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*G)-3')
Authors:Lee, Y.-S., Yang, W.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Nat.Struct.Mol.Biol., 22, 2015
2HJW
  • Download 2hjw
  • View 2hjw
Molmil generated image of 2hjw
CRYSTAL STRUCTURE OF THE BC DOMAIN OF ACC2
Descriptor:Acetyl-CoA carboxylase 2
Authors:Cho, Y.S., Lee, J.I., Shin, D., Kim, H.T., Lee, T.G., Heo, Y.S.
Deposit date:2006-07-02
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.
Proteins, 70, 2008
4N9H
  • Download 4n9h
  • View 4n9h
Molmil generated image of 4n9h
CRYSTAL STRUCTURE OF TRANSCRIPTION REGULATION PROTEIN CRP
Descriptor:Catabolite gene activator
Authors:Lee, B.J., Seok, S.H., Im, H., Yoon, H.J.
Deposit date:2013-10-21
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers.
Acta Crystallogr.,Sect.D, 70, 2014
4N9I
  • Download 4n9i
  • View 4n9i
Molmil generated image of 4n9i
CRYSTAL STRUCTURE OF TRANSCRIPTION REGULATION PROTEIN CRP COMPLEXED WITH CGMP
Descriptor:Catabolite gene activator, CYCLIC GUANOSINE MONOPHOSPHATE
Authors:Lee, B.-J., Seok, S.-H., Im, H., Yoon, H.-J.
Deposit date:2013-10-21
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers.
Acta Crystallogr.,Sect.D, 70, 2014
2G95
  • Download 2g95
  • View 2g95
Molmil generated image of 2g95
CRYSTAL STRUCTURE OF VISFATIN/PRE-B CELL COLONY ENHANCING FACTOR 1/NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE
Descriptor:Nicotinamide phosphoribosyltransferase
Authors:Kim, M.-K., Eom, S.H.
Deposit date:2006-03-05
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Visfatin/Pre-B Cell Colony-enhancing Factor 1/Nicotinamide Phosphoribosyltransferase, Free and in Complex with the Anti-cancer Agent FK-866
J.Mol.Biol., 362, 2006
<12>