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4QAG
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STRUCTURE OF A DIHYDROXYCOUMARIN ACTIVE-SITE INHIBITOR IN COMPLEX WITH THE RNASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor:Reverse transcriptase/ribonuclease H, MANGANESE (II) ION, (7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid
Authors:Himmel, D.M., Ho, W.C., Arnold, E.
Deposit date:2014-05-04
Release date:2014-06-04
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (1.712 Å)
Cite:Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs.
J.Mol.Biol., 426, 2014
3QLH
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HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH MANICOL AT THE RNASE H ACTIVE SITE AND TMC278 (RILPIVIRINE) AT THE NNRTI BINDING POCKET
Descriptor:reverse transcriptase/ribonuclease H, (2S)-5,7-dihydroxy-9-methyl-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-6H-benzo[7]annulen-6-one, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
Authors:Himmel, D.M., Wojtak, K., Bauman, J.D., Arnold, E.
Deposit date:2011-02-02
Release date:2011-12-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
J.Med.Chem., 54, 2011
4HKQ
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XMRV REVERSE TRANSCRIPTASE IN COMPLEX WITH RNA/DNA HYBRID
Descriptor:Reverse transcriptase/ribonuclease H p80, RNA (5'-R(*AP*AP*CP*AP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*CP*AP*U)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*A*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3')
Authors:Nowak, E., Potrzebowski, W., Konarev, P.V., Rausch, J.W., Bona, M.K., Svergun, D.I., Bujnicki, J.M., Le Grice, S.F.J., Nowotny, M.
Deposit date:2012-10-15
Release date:2013-02-20
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
Nucleic Acids Res., 41, 2013
4OL8
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TY3 REVERSE TRANSCRIPTASE BOUND TO DNA/RNA
Descriptor:Reverse transcriptase/ribonuclease H, 5'-R(*CP*UP*GP*AP*GP*AP*GP*AP*GP*AP*GP*GP*AP*AP*GP*AP*UP*G)-3', 5'-D(*CP*AP*TP*CP*TP*TP*CP*CP*TP*CP*TP*CP*TP*CP*TP*C)-3', ...
Authors:Nowak, E., Miller, J.T., Bona, M.K., Studnicka, J., Szczepanowski, R.H., Jurkowski, J., Le Grice, S.F.J., Nowotny, M.
Deposit date:2014-01-23
Release date:2014-03-05
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
Nat.Struct.Mol.Biol., 21, 2014
4B3O
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STRUCTURES OF HIV-1 RT AND RNA-DNA COMPLEX REVEAL A UNIQUE RT CONFORMATION AND SUBSTRATE INTERFACE
Descriptor:REVERSE TRANSCRIPTASE/RIBONUCLEASE H, P51 RT, 5'-D(*CP*GP*TP*AP*TP*GP*CP*CP*TP*AP*TP*AP*GP*TP *TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3', ...
Authors:Lapkouski, M., Tian, L., Miller, J.T., Le Grice, S.F.J., Yang, W.
Deposit date:2012-07-25
Release date:2013-01-16
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Complexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation
Nat.Struct.Mol.Biol., 20, 2013
4B3P
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STRUCTURES OF HIV-1 RT AND RNA-DNA COMPLEX REVEAL A UNIQUE RT CONFORMATION AND SUBSTRATE INTERFACE
Descriptor:REVERSE TRANSCRIPTASE/RIBONUCLEASE H, P51 RT, DNA, ...
Authors:Lapkouski, M., Tian, L., Miller, J.T., Le Grice, S.F.J., Yang, W.
Deposit date:2012-07-25
Release date:2013-01-16
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (4.839 Å)
Cite:Complexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation
Nat.Struct.Mol.Biol., 20, 2013
4B3Q
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STRUCTURES OF HIV-1 RT AND RNA-DNA COMPLEX REVEAL A UNIQUE RT CONFORMATION AND SUBSTRATE INTERFACE
Descriptor:REVERSE TRANSCRIPTASE/RIBONUCLEASE H, P51 RT, PRIMER DNA, ...
Authors:Lapkouski, M., Tian, L., Miller, J.T., Le Grice, S.F.J., Yang, W.
Deposit date:2012-07-25
Release date:2013-01-16
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (5 Å)
Cite:Complexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation
Nat.Struct.Mol.Biol., 20, 2013