Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1HY7
DownloadVisualize
BU of 1hy7 by Molmil
A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3
Descriptor: CALCIUM ION, R-2-{[4'-METHOXY-(1,1'-BIPHENYL)-4-YL]-SULFONYL}-AMINO-6-METHOXY-HEX-4-YNOIC ACID, STROMELYSIN-1, ...
Authors:Natchus, M.G, Bookland, R.G, Laufersweiler, M.J, Pikul, S, Almstead, N.G, De, B, Janusz, M.J, Hsieh, L.C, Gu, F, Pokross, M.E, Patel, V.S, Garver, S.M, Peng, S.X, Branch, T.M, King, S.L, Baker, T.R, Foltz, D.J, Mieling, G.E.
Deposit date:2001-01-18
Release date:2002-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
J.Med.Chem., 44, 2001
1YW2
DownloadVisualize
BU of 1yw2 by Molmil
Mutated Mus Musculus P38 Kinase (mP38)
Descriptor: 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE, Mitogen-activated protein kinase 14
Authors:Laughlin, S.K, Clark, M.P, Djung, J.F, Golebiowski, A, Brugel, T.A, Sabat, M, Bookland, R.G, Laufersweiler, M.J, Vanrens, J.C, Townes, J.A, De, B, Hsieh, L.C, Xu, S.C, Walter, R.L, Mekel, M.J, Janusz, M.J.
Deposit date:2005-02-16
Release date:2005-05-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.
Bioorg.Med.Chem.Lett., 15, 2005
1YWR
DownloadVisualize
BU of 1ywr by Molmil
Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor
Descriptor: 4-(4-FLUOROPHENYL)-1-METHYL-5-(2-{[(1S)-1-PHENYLETHYL]AMINO}PYRIMIDIN-4-YL)-2-PIPERIDIN-4-YL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE, Mitogen-activated protein kinase 14
Authors:Golebiowski, A, Townes, J.A, Laufersweiler, M.J, Brugel, T.A, Clark, M.P, Clark, C.M, Djung, J.F, Laughlin, S.K, Sabat, M.P, Bookland, R.G, Vanrens, J.C, De, B, Hsieh, L.C, Janusz, M.J, Walter, R.L, Webster, M.E, Mekel, M.J.
Deposit date:2005-02-18
Release date:2005-05-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The development of monocyclic pyrazolone based cytokine synthesis inhibitors.
Bioorg.Med.Chem.Lett., 15, 2005
2GHL
DownloadVisualize
BU of 2ghl by Molmil
Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743
Descriptor: 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA, Mitogen-activated protein kinase 14
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Brugel, T.A.
Deposit date:2006-03-27
Release date:2006-04-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1.
Bioorg.Med.Chem.Lett., 16, 2006
2GTM
DownloadVisualize
BU of 2gtm by Molmil
Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579
Descriptor: 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM, Mitogen-activated protein kinase 14
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M.
Deposit date:2006-04-28
Release date:2006-05-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.
Bioorg.Med.Chem.Lett., 16, 2006
2HK5
DownloadVisualize
BU of 2hk5 by Molmil
Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247
Descriptor: 3-{[2-(1H-BENZIMIDAZOL-1-YL)-6-{[2-(DIETHYLAMINO)ETHYL]AMINO}PYRIMIDIN-4-YL]AMINO}-4-METHYLPHENOL, Tyrosine-protein kinase HCK
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M.P.
Deposit date:2006-07-03
Release date:2006-09-05
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).
Bioorg.Med.Chem.Lett., 16, 2006
2GTN
DownloadVisualize
BU of 2gtn by Molmil
Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717
Descriptor: 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE, Mitogen-activated protein kinase 14, SULFATE ION
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M.
Deposit date:2006-04-28
Release date:2006-07-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.
Bioorg.Med.Chem.Lett., 16, 2006
2GHM
DownloadVisualize
BU of 2ghm by Molmil
Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449
Descriptor: 3-(2-CHLOROBENZYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA, Mitogen-activated protein kinase 14
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Maier, J.A.
Deposit date:2006-03-27
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1.
Bioorg.Med.Chem.Lett., 16, 2006

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon