2GHM

Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449

Summary for 2GHM

Entry DOI	10.2210/pdb2ghm/pdb
Related	1yw2 1ywr 2GHL
Descriptor	Mitogen-activated protein kinase 14, 3-(2-CHLOROBENZYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA (3 entities in total)
Functional Keywords	map kinase p38, transferase
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm : P47811
Total number of polymer chains	1
Total formula weight	40324.60
Authors	Walter, R.L.,Mekel, M.J.,Evdokimov, A.G.,Pokross, M.E.,Maier, J.A. (deposition date: 2006-03-27, release date: 2006-05-02, Last modification date: 2024-02-14)
Primary citation	Brugel, T.A.,Maier, J.A.,Clark, M.P.,Sabat, M.,Golebiowski, A.,Bookland, R.G.,Laufersweiler, M.J.,Laughlin, S.K.,Vanrens, J.C.,De, B.,Hsieh, L.C.,Mekel, M.J.,Janusz, M.J. Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1. Bioorg.Med.Chem.Lett., 16:3510-3513, 2006 Cited by PubMed: 16632356 DOI: 10.1016/j.bmcl.2006.03.095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation