1YW2

Mutated Mus Musculus P38 Kinase (mP38)

Summary for 1YW2

• Entry DOI: 10.2210/pdb1yw2/pdb
• Descriptor: Mitogen-activated protein kinase 14, 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE (3 entities in total)
• Functional Keywords: transferase
• Biological source: Mus musculus (house mouse)
• Cellular location: Cytoplasm : P47811
• Total number of polymer chains: 1
• Total formula weight: 41715.53

Authors

Laughlin, S.K.,Clark, M.P.,Djung, J.F.,Golebiowski, A.,Brugel, T.A.,Sabat, M.,Bookland, R.G.,Laufersweiler, M.J.,Vanrens, J.C.,Townes, J.A.,De, B.,Hsieh, L.C.,Xu, S.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J. (deposition date: 2005-02-16, release date: 2005-05-10, Last modification date: 2023-08-23)

• Primary citation: Laughlin, S.K.,Clark, M.P.,Djung, J.F.,Golebiowski, A.,Brugel, T.A.,Sabat, M.,Bookland, R.G.,Laufersweiler, M.J.,Vanrens, J.C.,Townes, J.A.,De, B.,Hsieh, L.C.,Xu, S.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J.; The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.; Bioorg.Med.Chem.Lett., 15:2399-2403, 2005; PubMed: 15837333; DOI: 10.1016/j.bmcl.2005.02.066

Experimental method

X-RAY DIFFRACTION (2.01 Å)