2HK5

Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247

Summary for 2HK5

• Entry DOI: 10.2210/pdb2hk5/pdb
• Descriptor: Tyrosine-protein kinase HCK, 3-{[2-(1H-BENZIMIDAZOL-1-YL)-6-{[2-(DIETHYLAMINO)ETHYL]AMINO}PYRIMIDIN-4-YL]AMINO}-4-METHYLPHENOL (3 entities in total)
• Functional Keywords: hck, src-family, kinase domain, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631
• Total number of polymer chains: 1
• Total formula weight: 31402.36

Authors

Walter, R.L.,Mekel, M.J.,Evdokimov, A.G.,Pokross, M.E.,Sabat, M.P. (deposition date: 2006-07-03, release date: 2006-09-05, Last modification date: 2024-04-03)

Primary citation

Sabat, M.,VanRens, J.C.,Laufersweiler, M.J.,Brugel, T.A.,Maier, J.,Golebiowski, A.,De, B.,Easwaran, V.,Hsieh, L.C.,Walter, R.L.,Mekel, M.J.,Evdokimov, A.,Janusz, M.J.
The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).
Bioorg.Med.Chem.Lett., 16:5973-5977, 2006

PubMed Abstract: This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).

PubMed: 16997556
DOI: 10.1016/j.bmcl.2006.08.132

Experimental method

X-RAY DIFFRACTION (2 Å)