Author results

4A14
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HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
Descriptor:KINESIN-LIKE PROTEIN KIF7, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Klejnot, M., Kozielski, F.
Deposit date:2011-09-14
Release date:2012-01-25
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
3ZCW
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EG5 - NEW ALLOSTERIC BINDING SITE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ulaganathan, V., Talapatra, S.K., Kozielski, F., Pannifer, A.D.
Deposit date:2012-11-23
Release date:2013-01-23
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.691 Å)
Cite:Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
J.Am.Chem.Soc., 135, 2013
2E9S
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HUMAN NEURONAL RAB6B IN THREE INTERMEDIATE FORMS
Descriptor:Ras-related protein Rab-6B, NITRATE ION, MAGNESIUM ION, ...
Authors:Vellieux, F.M., Tcherniuk, S., Garcia-Saez, I., Kozielski, F.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:3D structure of human neuronal Rab6B in three intermediate forms
To be Published
2FFQ
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THE CRYSTAL STRUCTURE OF HUMAN NEURONAL RAB6B IN ITS ACTIVE GTPGS-BOUND FORM
Descriptor:Ras-related protein Rab-6B, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Garcia-Saez, I., Tcherniuk, S., Kozielski, F.
Deposit date:2005-12-20
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The structure of human neuronal Rab6B in the active and inactive form.
Acta Crystallogr.,Sect.D, 62, 2006
6G6Y
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EG5-INHIBITOR COMPLEX
Descriptor:Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Talapatra, S.K., Kozielski, F., Tham, C.L.
Deposit date:2018-04-03
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Eur J Med Chem, 156, 2018
2XT3
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HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
Descriptor:KINESIN-LIKE PROTEIN KIF7, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Klejnot, M., Kozielski, F.
Deposit date:2010-10-04
Release date:2011-12-14
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.882 Å)
Cite:Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
2X7C
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-ENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2KIN
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KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS
Descriptor:KINESIN, SULFATE ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Sack, S., Muller, J., Kozielski, F., Marx, A., Thormahlen, M., Biou, V., Mandelkow, E.-M., Brady, S.T., Mandelkow, E.
Deposit date:1997-04-28
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of motor and neck domains from rat brain kinesin.
Biochemistry, 36, 1997
2WOG
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INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Hackney, D.D., Kozielski, F.
Deposit date:2009-07-23
Release date:2010-08-04
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex.
Biochem.J., 425, 2010
3PYM
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STRUCTURE OF GAPDH 3 FROM S.CEREVISIAE AT 2.0 A RESOLUTION
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase 3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, MESO-ERYTHRITOL, ...
Authors:Garcia-Saez, I., Kozielski, F., Job, D., Boscheron, C.
Deposit date:2010-12-13
Release date:2012-01-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:

5NJV
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FLAVIVIRUS NS5 DOMAIN
Descriptor:NS5, S-ADENOSYLMETHIONINE, CHLORIDE ION
Authors:Talapatra, S.K., Chatrin, C., Kozielski, F.
Deposit date:2017-03-29
Release date:2018-01-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping.
Oncotarget, 9, 2018
5NJU
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FLAVIVIRUS NS5 DOMAIN
Descriptor:Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, MAGNESIUM ION
Authors:Talapatra, S.K., Chatrin, C., Kozielski, F.
Deposit date:2017-03-29
Release date:2018-01-24
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping.
Oncotarget, 9, 2018
6FMQ
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KEAP1 - PEPTIDE COMPLEX
Descriptor:Kelch-like ECH-associated protein 1, ACY-SC1-GLU-THR-GLY-GLU-LEU, 1,2-ETHANEDIOL, ...
Authors:Talapatra, S.K., Kozielski, F., Wells, G., Georgakopoulos, N.D.
Deposit date:2018-02-02
Release date:2018-08-08
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids.
Chembiochem, 19, 2018
2X2R
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((4-CHLOROPHENYL)DIPHENYLMETHYLTHIO)PROPANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ...
Authors:Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
Deposit date:2010-01-15
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
2Y65
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER KINESIN-1 MOTOR DOMAIN DIMER-TAIL COMPLEX
Descriptor:KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kaan, H.Y.K., Hackney, D.D., Kozielski, F.
Deposit date:2011-01-19
Release date:2011-08-24
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition.
Science, 333, 2011
2FE4
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THE CRYSTAL STRUCTURE OF HUMAN NEURONAL RAB6B IN ITS INACTIVE GDP-BOUND FORM
Descriptor:Ras-related protein Rab-6B, MAGNESIUM ION, NITRATE ION, ...
Authors:Garcia-Saez, I., Tcherniuk, F., Kozielski, F.
Deposit date:2005-12-15
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of human neuronal Rab6B in the active and inactive form.
Acta Crystallogr.,Sect.D, 62, 2006
2X7D
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-DIMETHYLENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
6H80
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DENGUE-RDRP3-INHIBITOR COMPLEX CO-CRYSTALLISATION
Descriptor:Genome polyprotein, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, ZINC ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2018-07-31
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
2X7E
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-FLUORASTROL
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
4AS7
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EG5 COMPLEX 1
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2012-04-29
Release date:2013-05-15
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
6H9R
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DENGUE-RDRP3-INHIBITOR COMPLEX SOAKING
Descriptor:Genome polyprotein, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, ZINC ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2018-08-05
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
4A5Y
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INTERMEDIATE STATE OF HUMAN KINESIN EG5 IN COMPLEX WITH ISPINESIB
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2011-10-29
Release date:2012-11-07
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:"Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5.
J.Biol.Chem., 288, 2013
1T5C
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CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINETOCHORE PROTEIN CENP-E
Descriptor:Centromeric protein E, MAGNESIUM ION, NITRATE ION, ...
Authors:Garcia-Saez, I., Yen, T., Wade, R.H., Kozielski, F., Structural Proteomics in Europe (SPINE)
Deposit date:2004-05-04
Release date:2005-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the motor domain of the human kinetochore protein CENP-E.
J.Mol.Biol., 340, 2004
4B7B
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EG5-3
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2012-08-17
Release date:2013-07-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4A28
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EG5-2
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2011-09-22
Release date:2012-10-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
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