Author results

5AC9
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STRUCTURE-BASED ENERGETICS OF PROTEIN INTERFACES GUIDE FOOT-AND-MOUTH DISEASE VIRUS VACCINE DESIGN
Descriptor:VP1, VP3, VP2, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., PerezMartin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-14
Release date:2015-09-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design
Nat.Struct.Mol.Biol., 22, 2015
5ACA
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STRUCTURE-BASED ENERGETICS OF PROTEIN INTERFACES GUIDE FOOT-AND-MOUTH DISEASE VIRUS VACCINE DESIGN
Descriptor:VP1, VP2, VP3, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., Perez-Martin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-14
Release date:2015-09-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design
Nat.Struct.Mol.Biol., 22, 2015
5D8A
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CRYSTAL STRUCTURE OF RECOMBINANT FOOT-AND-MOUTH-DISEASE VIRUS A22-H2093F EMPTY CAPSID
Descriptor:VP1, VP2, VP3, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., Perez-Martin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-16
Release date:2015-09-23
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Nat.Struct.Mol.Biol., 22, 2015
5DDJ
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CRYSTAL STRUCTURE OF RECOMBINANT FOOT-AND-MOUTH-DISEASE VIRUS O1M-S2093Y EMPTY CAPSID
Descriptor:Foot and mouth disease virus, VP1, VP2, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., Perez-Martin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-25
Release date:2015-09-23
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Nat.Struct.Mol.Biol., 22, 2015
5NEM
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LOCALISED RECONSTRUCTION OF ALPHA V BETA 6 BOUND TO FOOT AND MOUTH DISEASE VIRUS O PANASIA - POSE A.
Descriptor:O PanAsia VP1, O PanAsia VP2, O PanAsia VP3, ...
Authors:Kotecha, A., Stuart, D.
Deposit date:2017-03-10
Release date:2017-06-21
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (10.8 Å)
Cite:Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.
Nat Commun, 8, 2017
5NET
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LOCALISED RECONSTRUCTION OF INTEGRIN ALPHA V BETA 6 BOUND TO FOOT AND MOUTH DISEASE VIRUS O1 MANISA - POSE A.
Descriptor:O1 Manisa VP1, O1 Manisa VP2, O1 Manisa VP3, ...
Authors:Kotecha, A., Stuart, D.
Deposit date:2017-03-11
Release date:2017-06-21
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.
Nat Commun, 8, 2017
5NE4
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CRYSTAL STRUCTURE OF FOOT AND MOUTH DISEASE VIRUS O PANASIA
Descriptor:O PanAsia VP1, O PanAsia VP2, Polyprotein, ...
Authors:Kotecha, A., StuarT, D.
Deposit date:2017-03-09
Release date:2017-06-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.
Nat Commun, 8, 2017
5NED
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CRYOEM STRUCTURE OF FOOT AND MOUTH DISEASE VIRUS O PANASIA
Descriptor:O PanAsia VP1, O PanAsia VP2, O PanAsia VP3, ...
Authors:Kotecha, A., Stuart, D.
Deposit date:2017-03-10
Release date:2017-06-21
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.
Nat Commun, 8, 2017
5NEJ
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CRYOEM STRUCTURE OF FOOT AND MOUTH DISEASE VIRUS O1 MANISA
Descriptor:O1 Manisa VP1, O1 Manisa VP2, O1 Manisa VP3
Authors:Kotecha, A., Stuart, D.
Deposit date:2017-03-10
Release date:2017-06-21
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.
Nat Commun, 8, 2017
5NER
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LOCALISED RECONSTRUCTION OF ALPHA V BETA 6 BOUND TO FOOT AND MOUTH DISEASE VIRUS O PANASIA - POSE A PRIME.
Descriptor:O PanAsia VP1, O PanAsia VP2, O PanAsia VP3, ...
Authors:Kotecha, A., Stuart, D.
Deposit date:2017-03-11
Release date:2017-06-21
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.
Nat Commun, 8, 2017
5NEU
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LOCALISED RECONSTRUCTION OF INTEGRIN ALPHA V BETA 6 BOUND TO FOOT AND MOUTH DISEASE VIRUS O1 MANISA - POSE B.
Descriptor:O1 Manisa VP1, O1 Manisa VP2, Capsid protein, ...
Authors:Kotecha, A., Stuart, D.
Deposit date:2017-03-11
Release date:2017-06-21
Last modified:2018-03-28
Method:ELECTRON MICROSCOPY (12.3 Å)
Cite:Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.
Nat Commun, 8, 2017
5OW6
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CRYOEM STRUCTURE OF RECOMBINANT CMV PARTICLES WITH TETANUS-EPITOPE
Descriptor:VP1, Capsid protein, VP2, ...
Authors:Kotecha, A., Stuart, D.I., Backmann, M.
Deposit date:2017-08-30
Release date:2017-09-13
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer's and cat allergy.
NPJ Vaccines, 2, 2017
5OWX
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INSIDE-OUT FMDV A10 CAPSID
Descriptor:Genome polyprotein
Authors:Kotecha, A., Malik, N., Fry, E.E., Stuart, D.I.
Deposit date:2017-09-04
Release date:2017-09-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation.
PLoS Pathog., 13, 2017
5OYI
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FMDV A10 DISSOCIATED PENTAMER
Descriptor:Genome polyprotein
Authors:Kotecha, A., Malik, N., Stuart, D.I.
Deposit date:2017-09-09
Release date:2017-09-20
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation.
PLoS Pathog., 13, 2017
6XF8
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DLP 5 FOLD
Descriptor:Outer capsid protein mu-1, Outer capsid protein sigma-3, Inner capsid protein sigma-2, ...
Authors:Sutton, G., Sun, D.P., Fu, X.F., Kotecha, A., Hecksel, G.W., Clare, D.K., Zhang, P., Stuart, D., Boyce, M.
Deposit date:2020-06-15
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Assembly intermediates of orthoreovirus captured in the cell.
Nat Commun, 11, 2020
3JB4
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STRUCTURE OF LJUNGAN VIRUS: INSIGHT INTO PICORNAVIRUS PACKAGING
Descriptor:VP1, VP0, VP3
Authors:Zhu, L., Wang, X.X., Ren, J.S., Porta, C., Wenham, H., Ekstrom, J.-O., Panjwani, A., Knowles, N.J., Kotecha, A., Siebert, A., Lindberg, M., Fry, E.E., Rao, Z.H., Tuthill, T.J., Stuart, D.I.
Deposit date:2015-07-21
Release date:2015-10-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of Ljungan virus provides insight into genome packaging of this picornavirus.
Nat Commun, 6, 2015
5M0Q
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CRYO-EM RECONSTRUCTION OF THE MAEDI-VISNA VIRUS (MVV) INTASOME
Descriptor:integrase, vDNA, non-transferred strand, ...
Authors:Ballandras-Colas, A., Maskell, D., Pye, V.E., Locke, J., Swuec, S., Kotecha, A., Costa, A., Cherepanov, P.
Deposit date:2016-10-05
Release date:2017-01-18
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.91 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
5M0R
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CRYO-EM RECONSTRUCTION OF THE MAEDI-VISNA VIRUS (MVV) STRAND TRANSFER COMPLEX
Descriptor:integrase, vDNA, non-transfered strand, ...
Authors:Pye, V.E., Ballandras-Colas, A., Maskell, D., Locke, J., Kotecha, A., Costa, A., Cherepanov, P.
Deposit date:2016-10-05
Release date:2017-01-18
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
5OSN
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CRYSTAL STRUCTURE OF BOVINE ENTEROVIRUS 2 DETERMINED WITH SERIAL FEMTOSECOND X-RAY CRYSTALLOGRAPHY
Descriptor:Capsid protein, SPHINGOSINE, POTASSIUM ION, ...
Authors:Roedig, P., Ginn, H.M., Pakendorf, T., Sutton, G., Harlos, K., Walter, T.S., Meyer, J., Fischer, P., Duman, R., Vartiainen, I., Reime, B., Warmer, M., Brewster, A.S., Young, I.D., Michels-Clark, T., Sauter, N.K., Kotecha, A., Kelly, J., Rowlands, D.J., Sikorsky, M., Nelson, S., Damiani, D.S., Alonso-Mori, R., Ren, J., Fry, E.E., David, C., Stuart, D.I., Wagner, A., Meents, A.
Deposit date:2017-08-17
Release date:2017-08-30
Last modified:2019-07-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-speed fixed-target serial virus crystallography.
Nat. Methods, 14, 2017
4IV1
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CRYSTAL STRUCTURE OF RECOMBINANT FOOT-AND-MOUTH-DISEASE VIRUS A22 EMPTY CAPSID
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
Authors:Porta, C., Kotecha, A., Burman, A., Jackson, T., Ren, J., Loureiro, S., Jones, I.M., Fry, E.E., Stuart, D.I., Charleston, B.
Deposit date:2013-01-22
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen.
Plos Pathog., 9, 2013
4IV3
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CRYSTAL STRUCTURE OF RECOMBINANT FOOT-AND-MOUTH-DISEASE VIRUS A22-H2093C EMPTY CAPSID
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
Authors:Porta, C., Kotecha, A., Burman, A., Jackson, T., Ren, J., Loureiro, S., Jones, I.M., Fry, E.E., Stuart, D.I., Charleston, B.
Deposit date:2013-01-22
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen.
Plos Pathog., 9, 2013
7A4M
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CRYO-EM STRUCTURE OF MOUSE HEAVY-CHAIN APOFERRITIN AT 1.22 A
Descriptor:Ferritin heavy chain, FE (III) ION, ZINC ION
Authors:Nakane, T., Kotecha, A., Sente, A., Yamashita, K., McMullan, G., Masiulis, S., Brown, P.M.G.E., Grigoras, I.T., Malinauskaite, L., Malinauskas, T., Miehling, J., Yu, L., Karia, D., Pechnikova, E.V., de Jong, E., Keizer, J., Bischoff, M., McCormack, J., Tiemeijer, P., Hardwick, S.W., Chirgadze, D.Y., Murshudov, G., Aricescu, A.R., Scheres, S.H.W.
Deposit date:2020-08-20
Release date:2020-10-28
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (1.22 Å)
Cite:Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
7A5V
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CRYOEM STRUCTURE OF A HUMAN GAMMA-AMINOBUTYRIC ACID RECEPTOR, THE GABA(A)R-BETA3 HOMOPENTAMER, IN COMPLEX WITH HISTAMINE AND MEGABODY MB25 IN LIPID NANODISC
Descriptor:Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, Megabody Mb25, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nakane, T., Kotecha, A., Sente, A., Yamashita, K., McMullan, G., Masiulis, S., Brown, P.M.G.E., Grigoras, I.T., Malinauskaite, L., Malinauskas, T., Miehling, J., Yu, L., Karia, D., Pechnikova, E.V., de Jong, E., Keizer, J., Bischoff, M., McCormack, J., Tiemeijer, P., Hardwick, S.W., Chirgadze, D.Y., Murshudov, G., Aricescu, A.R., Scheres, S.H.W.
Deposit date:2020-08-22
Release date:2020-11-18
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (1.7 Å)
Cite:Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
5FJ5
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STRUCTURE OF THE IN VITRO ASSEMBLED BACTERIOPHAGE PHI6 POLYMERASE COMPLEX
Descriptor:MAJOR INNER PROTEIN P1
Authors:Ilca, S., Kotecha, A., Sun, X., Poranen, M.P., Stuart, D.I., Huiskonen, J.T.
Deposit date:2015-10-06
Release date:2015-11-04
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes.
Nat.Commun., 6, 2015
5FJ6
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STRUCTURE OF THE P2 POLYMERASE INSIDE IN VITRO ASSEMBLED BACTERIOPHAGE PHI6 POLYMERASE COMPLEX
Descriptor:RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION
Authors:Ilca, S., Kotecha, A., Sun, X., Poranen, M.P., Stuart, D.I., Huiskonen, J.T.
Deposit date:2015-10-06
Release date:2015-11-04
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes.
Nat.Commun., 6, 2015
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PDB entries from 2020-11-25