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2BNH
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BU of 2bnh by Molmil
PORCINE RIBONUCLEASE INHIBITOR
Descriptor: RIBONUCLEASE INHIBITOR
Authors:Kobe, B, Deisenhofer, J.
Deposit date:1996-06-29
Release date:1997-03-12
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A.
J.Mol.Biol., 264, 1996
1DFJ
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BU of 1dfj by Molmil
RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A
Descriptor: RIBONUCLEASE A, RIBONUCLEASE INHIBITOR, SULFATE ION
Authors:Kobe, B, Deisenhofer, J.
Deposit date:1996-06-29
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural basis of the interactions between leucine-rich repeats and protein ligands.
Nature, 374, 1995
2PHM
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BU of 2phm by Molmil
STRUCTURE OF PHENYLALANINE HYDROXYLASE DEPHOSPHORYLATED
Descriptor: FE (III) ION, PROTEIN (PHENYLALANINE-4-HYDROXYLASE)
Authors:Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E.
Deposit date:1998-11-11
Release date:1999-04-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of autoregulation of phenylalanine hydroxylase.
Nat.Struct.Biol., 6, 1999
1PHZ
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BU of 1phz by Molmil
STRUCTURE OF PHOSPHORYLATED PHENYLALANINE HYDROXYLASE
Descriptor: FE (III) ION, PROTEIN (PHENYLALANINE HYDROXYLASE)
Authors:Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E.
Deposit date:1998-11-11
Release date:1999-04-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of autoregulation of phenylalanine hydroxylase.
Nat.Struct.Biol., 6, 1999
1IAL
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BU of 1ial by Molmil
IMPORTIN ALPHA, MOUSE
Descriptor: IMPORTIN ALPHA
Authors:Kobe, B.
Deposit date:1999-01-12
Release date:1999-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.
Nat.Struct.Biol., 6, 1999
1KOB
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BU of 1kob by Molmil
TWITCHIN KINASE FRAGMENT (APLYSIA), AUTOREGULATED PROTEIN KINASE DOMAIN
Descriptor: TWITCHIN, VALINE
Authors:Kobe, B, Heierhorst, J, Feil, S.C, Parker, M.W, Benian, G.M, Weiss, K.R, Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1KOA
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BU of 1koa by Molmil
TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
Descriptor: TWITCHIN
Authors:Kobe, B, Heierhorst, J, Feil, S.C, Parker, M.W, Benian, G.M, Weiss, K.R, Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1MG1
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BU of 1mg1 by Molmil
HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA
Descriptor: CHLORIDE ION, PROTEIN (HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Kobe, B, Center, R.J, Kemp, B.E, Poumbourios, P.
Deposit date:1999-03-01
Release date:1999-04-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins.
Proc.Natl.Acad.Sci.USA, 96, 1999
4UTP
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BU of 4utp by Molmil
Crystal structure of pneumococcal surface antigen PsaA in the Cd- bound, closed state
Descriptor: CADMIUM ION, MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN
Authors:Luo, Z, Counago, R.M, Maher, M, Kobe, B.
Deposit date:2014-07-22
Release date:2014-08-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.
Nat Commun, 6, 2015
4UTO
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BU of 4uto by Molmil
Crystal structure of pneumococcal surface antigen PsaA D280N in the Cd-bound, open state
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN
Authors:Luo, Z, Counago, R.M, Maher, M, Kobe, B.
Deposit date:2014-07-22
Release date:2015-03-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.
Nat Commun, 6, 2015
8STB
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BU of 8stb by Molmil
The structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX
Descriptor: CHLORIDE ION, GLYCEROL, Glyoxalase, ...
Authors:Luo, Z, Jia, X, Yan, X, Qu, X, Kobe, B.
Deposit date:2023-05-09
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The crystal structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX.
To Be Published
6VZB
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BU of 6vzb by Molmil
Crystal structure of cytochrome P450 NasF5053 S284A-V288A mutant variant from Streptomyces sp. NRRL F-5053 in the cyclo-L-Trp-L-Pro-bound state
Descriptor: (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ...
Authors:Luo, Z, Jia, X, Sun, C, Qu, X, Kobe, B.
Deposit date:2020-02-28
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Nat Commun, 11, 2020
6VZA
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BU of 6vza by Molmil
Crystal structure of cytochrome P450 NasF5053 Q65I-A86G mutant variant from Streptomyces sp. NRRL F-5053 in the cyclo-L-Trp-L-Pro-bound state
Descriptor: (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, CHLORIDE ION, ...
Authors:Luo, Z, Jia, X, Sun, C, Qu, X, Kobe, B.
Deposit date:2020-02-28
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Nat Commun, 11, 2020
6VXV
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BU of 6vxv by Molmil
Crystal structure of cyclo-L-Trp-L-Pro-bound cytochrome P450 NasF5053 from Streptomyces sp. NRRL F-5053
Descriptor: (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Luo, Z, Jia, X, Sun, C, Qu, X, Kobe, B.
Deposit date:2020-02-24
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Nat Commun, 11, 2020
1PJN
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BU of 1pjn by Molmil
Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex
Descriptor: Histone-binding protein N1/N2, Importin alpha-2 subunit
Authors:Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B.
Deposit date:2003-06-03
Release date:2003-08-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
J.Biol.Chem., 278, 2003
1PJM
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BU of 1pjm by Molmil
Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex
Descriptor: Importin alpha-2 subunit, Retinoblastoma-associated protein
Authors:Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B.
Deposit date:2003-06-03
Release date:2003-08-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
J.Biol.Chem., 278, 2003
6WES
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BU of 6wes by Molmil
Crystal structure of the effector SnTox3 from Parastagonospora nodorum
Descriptor: Tox3
Authors:Outram, M.A, Williams, S.J, Ericsson, D.J, Kobe, B, Solomon, P.S.
Deposit date:2020-04-02
Release date:2020-11-04
Last modified:2021-09-01
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and provides insight into Snn3 recognition and pro-domain protease processing of fungal effectors.
New Phytol., 231, 2021
5TEC
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BU of 5tec by Molmil
Crystal structure of the TIR domain from the Arabidopsis thaliana NLR protein SNC1
Descriptor: Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
Authors:Zhang, X, Bentham, A, Ve, T, Williams, S.J, Kobe, B.
Deposit date:2016-09-20
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multiple functional self-association interfaces in plant TIR domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8JZM
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BU of 8jzm by Molmil
The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210
Descriptor: Toll/interleukin-1 receptor domain-containing adapter protein
Authors:Rahaman, M.H, Jia, X, Maxwell, M.J, Mobli, M, Kobe, B.
Deposit date:2023-07-05
Release date:2024-05-01
Method:SOLUTION NMR
Cite:o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
J Enzyme Inhib Med Chem, 39, 2024
3EA5
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BU of 3ea5 by Molmil
Kap95p Binding Induces the Switch Loops of RanGDP to adopt the GTP-bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, Importin subunit beta-1, ...
Authors:Forwood, J.K, Lonhienne, J.K, Guncar, G, Stewart, M, Marfori, M, Kobe, B.
Deposit date:2008-08-24
Release date:2008-10-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.
J.Mol.Biol., 383, 2008
3L3Q
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BU of 3l3q by Molmil
Mouse importin alpha-pepTM NLS peptide complex
Descriptor: CITRATE ANION, Importin subunit alpha-2, pepTM
Authors:Takeda, A.A.S, Kobe, B, Fontes, M.R.M.
Deposit date:2009-12-17
Release date:2010-04-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening.
J.Biol.Chem., 285, 2010
7BER
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BU of 7ber by Molmil
SFX structure of the MyD88 TIR domain higher-order assembly (solved, rebuilt and refined using an identical protocol to the MicroED structure of the MyD88 TIR domain higher-order assembly)
Descriptor: Myeloid differentiation primary response protein MyD88
Authors:Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T.
Deposit date:2020-12-24
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
7BEQ
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BU of 7beq by Molmil
MicroED structure of the MyD88 TIR domain higher-order assembly
Descriptor: Myeloid differentiation primary response protein MyD88
Authors:Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T.
Deposit date:2020-12-24
Release date:2021-03-10
Last modified:2024-01-31
Method:ELECTRON CRYSTALLOGRAPHY (3 Å)
Cite:MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
1EJY
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BU of 1ejy by Molmil
MOUSE IMPORTIN ALPHA-NUCLEOPLASMIN NLS PEPTIDE COMPLEX
Descriptor: IMPORTIN ALPHA, NUCLEOPLASMIN NLS PEPTIDE
Authors:Fontes, M.R, Teh, T, Kobe, B.
Deposit date:2000-03-05
Release date:2000-04-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
J.Mol.Biol., 297, 2000
1EJL
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BU of 1ejl by Molmil
MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX
Descriptor: IMPORTIN ALPHA, SV40 LARGE T ANTIGEN NLS PEPTIDE
Authors:Fontes, M.R, Teh, T, Kobe, B.
Deposit date:2000-03-03
Release date:2000-04-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
J.Mol.Biol., 297, 2000

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