3MDD
 
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3MDE
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2NYQ
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2IQ6
 | | Crystal Structure of the Aminopeptidase from Vibrio proteolyticus in Complexation with Leucyl-leucyl-leucine. | | Descriptor: | Bacterial leucyl aminopeptidase, Peptide, (Leucyl-leucyl-leucine), ... | | Authors: | Kumar, A, Narayanan, B, Kim, J.-J.P, Bennett, B. | | Deposit date: | 2006-10-13 | | Release date: | 2007-08-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Experimental evidence for a metallohydrolase mechanism in which the nucleophile is not delivered by a metal ion: EPR spectrokinetic and structural studies of aminopeptidase from Vibrio proteolyticus
Biochem.J., 403, 2007
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2CW6
 | | Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria | | Descriptor: | 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, mitochondrial, ... | | Authors: | Fu, Z, Runquist, J.A, Hunt, J.F, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2005-06-17 | | Release date: | 2005-12-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
J.Biol.Chem., 281, 2006
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2G7N
 | | Structure of the Light Chain of Botulinum Neurotoxin Serotype A Bound to small Molecule Inhibitors | | Descriptor: | Botulinum neurotoxin type A, SILVER ION, ZINC ION | | Authors: | Fu, Z, Baldwin, M.R, Boldt, G.E, Janda, K.D, Barbieri, J.T, Kim, J.-J.P. | | Deposit date: | 2006-02-28 | | Release date: | 2007-03-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the Light Chain of Botulinum Neurotoxin Serotype A bound to Small Molecule Inhibitors
To be Published
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1SYO
 | | N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-alpha-D-mannopyranose, GLYCEROL, ... | | Authors: | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | Deposit date: | 2004-04-01 | | Release date: | 2004-06-29 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor
J.Biol.Chem., 279, 2004
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1Q25
 | | Crystal structure of N-terminal 3 domains of CI-MPR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | Deposit date: | 2003-07-23 | | Release date: | 2004-06-29 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor
Embo J., 23, 2004
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1SZ0
 | | N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | Deposit date: | 2004-04-01 | | Release date: | 2004-06-29 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor
J.Biol.Chem., 279, 2004
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1XX4
 | | Crystal Structure of Rat Mitochondrial 3,2-Enoyl-CoA | | Descriptor: | 3,2-trans-enoyl-CoA isomerase, mitochondrial, BENZAMIDINE, ... | | Authors: | Hubbard, P.A, Yu, W, Schulz, H, Kim, J.-J. | | Deposit date: | 2004-11-03 | | Release date: | 2004-11-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Domain swapping in the low-similarity isomerase/hydratase superfamily: the crystal structure of rat mitochondrial Delta3, Delta2-enoyl-CoA isomerase.
Protein Sci., 14, 2005
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3ES9
 | | NADPH-Cytochrome P450 Reductase in an Open Conformation | | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Hamdane, D, Xia, C, Im, S.-C, Zhang, H, Kim, J.-J, Waskell, L. | | Deposit date: | 2008-10-05 | | Release date: | 2009-01-20 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450
J.Biol.Chem., 284, 2009
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6P8I
 | | N-terminal 5 domains of IGFIIR | | Descriptor: | Cation-independent mannose-6-phosphate receptor, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | Deposit date: | 2019-06-07 | | Release date: | 2020-06-24 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor.
Commun Biol, 3, 2020
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3RMY
 | | Crystal structure of HCR/D W1238A mutant | | Descriptor: | Botulinum neurotoxin type D, GLYCEROL | | Authors: | Fu, Z, Karalewitz, A, Kroken, A, Kim, J.-J.P, Barbieri, J.T. | | Deposit date: | 2011-04-21 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Novel Ganglioside-mediated Entry of Botulinum Neurotoxin Serotype D into Neurons.
J.Biol.Chem., 286, 2011
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3RSJ
 | | Structure of HCRF in complex with Ganglioside GD1a | | Descriptor: | BoNT/F, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose, ... | | Authors: | Fu, Z, Benson, M.A, Barbieri, J.T, Kim, J.-J.P, Baldwin, M.R. | | Deposit date: | 2011-05-02 | | Release date: | 2011-08-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Unique ganglioside recognition strategies for clostridial neurotoxins.
J.Biol.Chem., 286, 2011
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4XQM
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1KEO
 | | TWISTS AND TURNS OF THE CD-MPR: LIGAND-BOUND VERSUS LIGAND-FREE RECEPTOR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, cation-dependent mannose-6-phosphate receptor | | Authors: | Olson, L.J, Zhang, J, Dahms, N.M, Kim, J.J. | | Deposit date: | 2001-11-16 | | Release date: | 2002-01-23 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Twists and turns of the cation-dependent mannose 6-phosphate receptor. Ligand-bound versus ligand-free receptor
J.Biol.Chem., 277, 2002
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6V02
 | | N-terminal 5 domains of CI-MPR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor | | Authors: | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | Deposit date: | 2019-11-18 | | Release date: | 2020-09-30 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor.
Commun Biol, 3, 2020
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4FVV
 | | Crystal structure of HCR/D-Sa-GBL1/C | | Descriptor: | GLYCEROL, N-acetyl-alpha-neuraminic acid, Neurotoxin, ... | | Authors: | Fu, Z, Karalewitz, A, Baldwin, M.R, Kim, J.-J.P, Barbieri, J.T. | | Deposit date: | 2012-06-29 | | Release date: | 2012-10-24 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry.
J.Biol.Chem., 287, 2012
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3MP4
 | | Crystal structure of Human lyase R41M mutant | | Descriptor: | Hydroxymethylglutaryl-CoA lyase | | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2010-04-24 | | Release date: | 2010-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3MP3
 | | Crystal Structure of Human Lyase in complex with inhibitor HG-CoA | | Descriptor: | (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ... | | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2010-04-24 | | Release date: | 2010-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3MP5
 | | Crystal Structure of Human Lyase R41M in complex with HMG-CoA | | Descriptor: | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, Hydroxymethylglutaryl-CoA lyase, MAGNESIUM ION | | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2010-04-24 | | Release date: | 2010-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3HN1
 | | Crystal structure of HCR/T complexed with GT2 and lactose | | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid, SULFATE ION, Tetanus toxin, ... | | Authors: | Chen, C, Fu, Z, Kim, J.-J.P, Barbieri, J.T, Baldwin, M.R. | | Deposit date: | 2009-05-29 | | Release date: | 2009-07-14 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Gangliosides as high affinity receptors for tetanus neurotoxin.
J.Biol.Chem., 284, 2009
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3HMY
 | | Crystal structure of HCR/T complexed with GT2 | | Descriptor: | GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid, SULFATE ION, ... | | Authors: | Chen, C, Fu, Z, Kim, J.-J.P, Barbieri, J.T, Baldwin, M.R. | | Deposit date: | 2009-05-29 | | Release date: | 2009-07-14 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Gangliosides as high affinity receptors for tetanus neurotoxin.
J.Biol.Chem., 284, 2009
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2RL9
 | | Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to trimannoside | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, Cation-dependent mannose-6-phosphate receptor, ... | | Authors: | Olson, L.J, Hindsgaul, O, Dahms, N.M, Kim, J.-J.P. | | Deposit date: | 2007-10-18 | | Release date: | 2008-02-12 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor.
J.Biol.Chem., 283, 2008
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2RL7
 | | Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 4.8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CACODYLATE ION, ... | | Authors: | Olson, L.J, Hindsgaul, O, Kim, J.-J.P, Dahms, N.M. | | Deposit date: | 2007-10-18 | | Release date: | 2008-02-12 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Insights into the Mechanism of pH-dependent Ligand Binding and Release by the Cation-dependent Mannose 6-Phosphate Receptor.
J.Biol.Chem., 283, 2008
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