4FVV

Crystal structure of HCR/D-Sa-GBL1/C

Summary for 4FVV

• Entry DOI: 10.2210/pdb4fvv/pdb
• Related: 3N7L
• Descriptor: Neurotoxin, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: botulinum toxin, ganglioside bing loop, ganglioside, toxin
• Biological source: Clostridium botulinum
• Total number of polymer chains: 2
• Total formula weight: 98681.89

Authors

Fu, Z.,Karalewitz, A.,Baldwin, M.R.,Kim, J.-J.P.,Barbieri, J.T. (deposition date: 2012-06-29, release date: 2012-10-24, Last modification date: 2023-09-13)

Primary citation

Karalewitz, A.P.,Fu, Z.,Baldwin, M.R.,Kim, J.J.,Barbieri, J.T.
Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry.
J.Biol.Chem., 287:40806-40816, 2012

PubMed Abstract: How botulinum neurotoxin serotype C (BoNT/C) enters neurons is unclear.

PubMed: 23027864
DOI: 10.1074/jbc.M112.404244

Experimental method

X-RAY DIFFRACTION (2.7 Å)